Detalhe da pesquisa
1.
Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Substrate of Cytochrome P450 and Aldehyde Oxidase, Using Chimeric Mice With Humanized Liver.
Drug Metab Dispos
; 51(1): 67-80, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36273823
2.
CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate.
Drug Metab Dispos
; 50(3): 235-242, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34930785
3.
Pharmacokinetics and metabolism of mirogabalin, a novel α2δ ligand, in rats and monkeys.
Xenobiotica
; 52(1): 54-64, 2022 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-35249464
4.
Estimation of fraction of drug metabolism by a single UDP-glucuronosyl transferase enzyme using relative expression factor.
Biopharm Drug Dispos
; 43(5): 213-217, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-36151066
5.
Critical Impact of Drug-Drug Interactions via Intestinal CYP3A in the Risk Assessment of Weak Perpetrators Using Physiologically Based Pharmacokinetic Models.
Drug Metab Dispos
; 48(4): 288-296, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31996361
6.
Stereoselective hydroxylation by CYP2C19 and oxidation by ADH4 in the in vitro metabolism of tivantinib.
Xenobiotica
; 46(11): 967-76, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26899628
7.
Bioactivation of loxoprofen to a pharmacologically active metabolite and its disposition kinetics in human skin.
Biopharm Drug Dispos
; 36(6): 352-363, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25765700
8.
Raludotatug Deruxtecan, a CDH6-Targeting Antibody-Drug Conjugate with a DNA Topoisomerase I Inhibitor DXd, Is Efficacious in Human Ovarian and Kidney Cancer Models.
Mol Cancer Ther
; 23(3): 257-271, 2024 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38205802
9.
DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-Based Antibody-Drug Conjugate Targeting B7-H3, Exerts Potent Antitumor Activities in Preclinical Models.
Mol Cancer Ther
; 21(4): 635-646, 2022 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35149548
10.
Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite.
Drug Metab Dispos
; 38(1): 92-9, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19812348
11.
Quizartinib, a selective FLT3 inhibitor, maintains antileukemic activity in preclinical models of RAS-mediated midostaurin-resistant acute myeloid leukemia cells.
Oncotarget
; 11(11): 943-955, 2020 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32215183
12.
A Potent Blood-Brain Barrier-Permeable Mutant IDH1 Inhibitor Suppresses the Growth of Glioblastoma with IDH1 Mutation in a Patient-Derived Orthotopic Xenograft Model.
Mol Cancer Ther
; 19(2): 375-383, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31727689
13.
Mechanism-based inhibition of human cytochrome P450 2B6 by ticlopidine, clopidogrel, and the thiolactone metabolite of prasugrel.
Drug Metab Dispos
; 37(3): 589-93, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19047469
14.
Effect of inter-individual variability in human liver cytochrome P450 isozymes on cyclophosphamide-induced micronucleus formation.
Mutat Res Genet Toxicol Environ Mutagen
; 838: 37-45, 2019 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-30678826
15.
Identification of non-P450 enzymes involved in the metabolism of new drugs: Their significance in drug interaction evaluation and prodrug disposition.
Drug Metab Pharmacokinet
; 35(1): 45-55, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31926835
16.
Comparison of human cytochrome P450 inhibition by the thienopyridines prasugrel, clopidogrel, and ticlopidine.
Drug Metab Pharmacokinet
; 23(6): 412-20, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-19122335
17.
Enantioselective 2-hydroxylation of RS-8359, a selective and reversible MAO-A inhibitor, by cytochrome P450 in mouse and rat liver microsomes.
Chirality
; 18(8): 592-8, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16642492