Detalhe da pesquisa
1.
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.
Nat Chem Biol
; 14(2): 163-170, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29251720
2.
Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP Binding Site at the Dimer Interface of Procaspase-6.
Biochemistry
; 58(52): 5320-5328, 2019 12 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-31095371
3.
ERK5 kinase activity is dispensable for cellular immune response and proliferation.
Proc Natl Acad Sci U S A
; 113(42): 11865-11870, 2016 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27679845
4.
Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma.
Blood
; 128(2): 239-48, 2016 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27151888
5.
Chemoproteomic Evaluation of Target Engagement by the Cyclin-Dependent Kinase 4 and 6 Inhibitor Palbociclib Correlates with Cancer Cell Response.
Biochemistry
; 55(38): 5434-41, 2016 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27571378
6.
ATP Acyl Phosphate Reactivity Reveals Native Conformations of Hsp90 Paralogs and Inhibitor Target Engagement.
Biochemistry
; 54(19): 3024-36, 2015 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25905789
7.
Monitoring native p38α:MK2/3 complexes via trans delivery of an ATP acyl phosphate probe.
J Am Chem Soc
; 136(12): 4664-9, 2014 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24601623
8.
Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.
Nat Chem Biol
; 7(4): 203-5, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21378983
9.
Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors.
Bioorg Med Chem Lett
; 23(18): 5217-22, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23916259
10.
PIP5K1C phosphoinositide kinase deficiency distinguishes PIKFYVE-dependent cancer cells from non-malignant cells.
Autophagy
; 19(9): 2464-2484, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36803256
11.
IOA-244 is a Non-ATP-competitive, Highly Selective, Tolerable PI3K Delta Inhibitor That Targets Solid Tumors and Breaks Immune Tolerance.
Cancer Res Commun
; 3(4): 576-591, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37066023
12.
6-Position optimization of tricyclic 4-quinolone-based inhibitors of glycogen synthase kinase-3ß: discovery of nitrile derivatives with picomolar potency.
Bioorg Med Chem Lett
; 22(2): 1005-8, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22202172
13.
Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.
J Pharmacol Exp Ther
; 338(1): 114-24, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21505060
14.
Synthesis and structure-activity relationship of 4-quinolone-3-carboxylic acid based inhibitors of glycogen synthase kinase-3ß.
Bioorg Med Chem Lett
; 21(19): 5948-51, 2011 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21873061
15.
Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH).
Bioorg Med Chem Lett
; 19(10): 2865-9, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19386497
16.
Direct CDKN2 Modulation of CDK4 Alters Target Engagement of CDK4 Inhibitor Drugs.
Mol Cancer Ther
; 18(4): 771-779, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30837298
17.
High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity.
Commun Biol
; 2: 345, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31552298
18.
Erratum: Author Correction: High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity.
Commun Biol
; 2: 438, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31799439
19.
Correction: Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics.
PLoS One
; 12(2): e0172649, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28199383
20.
Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics.
PLoS One
; 11(3): e0152934, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27031502