Detalhe da pesquisa
1.
Small-molecule inhibitors of human mitochondrial DNA transcription.
Nature
; 588(7839): 712-716, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33328633
2.
Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.
J Biol Chem
; 292(20): 8158-8173, 2017 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28325835
3.
Interaction of KRas4B protein with C6-ceramide containing lipid model membranes.
Biochim Biophys Acta Biomembr
; 1860(5): 1008-1014, 2018 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-29357287
4.
Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening.
Biochemistry
; 56(30): 3972-3982, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28681606
5.
Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site.
Chemistry
; 23(25): 6083-6093, 2017 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27809361
6.
Cheminformatics at the interface of medicinal chemistry and proteomics.
Biochim Biophys Acta
; 1844(1 Pt A): 156-61, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23707564
7.
Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents.
Bioorg Med Chem
; 22(18): 5097-109, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24398384
8.
Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors.
J Med Chem
; 65(9): 6643-6655, 2022 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35486541
9.
The Evolving Role of the Medicinal Chemist.
Prog Med Chem
; 55: 193-226, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26852936
10.
S1P receptor mediated activity of FTY720 phosphate mimics.
Bioorg Med Chem Lett
; 20(5): 1485-7, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20153186
11.
4,5,6-Trisubstituted piperidinones as conformationally restricted ceramide analogues: synthesis and evaluation as inhibitors of sphingosine and ceramide kinases and as NKT cell-stimulatory antigens.
Chem Biodivers
; 6(10): 1688-715, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19842132
12.
Synthesis of 7-aza- and 7-thiasphingosines, and evaluation of their interaction with sphingosine kinases and with T-cells.
Chem Biodivers
; 6(5): 725-38, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19479838
13.
Synthesis and evaluation of sphingolipid analogues: modification of the hydroxy group at C(1) of 7-oxasphingosine, and of the hydroxy group at C(1) and the amide group of 7-oxaceramides.
Chem Biodivers
; 6(5): 705-24, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19479849
14.
Chemical Validation of DegS As a Target for the Development of Antibiotics with a Novel Mode of Action.
ChemMedChem
; 14(11): 1074-1078, 2019 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30945468
15.
Dual Inhibition of GSK3ß and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo.
Stem Cell Reports
; 12(3): 502-517, 2019 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30773488
16.
An efficient, one-pot synthesis of various ceramide 1-phosphates from sphingosine 1-phosphate.
Chem Phys Lipids
; 151(2): 125-8, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18039471
17.
Structure-activity relationship studies on a novel class of antiproliferative agents derived from Lavendustin A. Part I: Ring A modifications.
Bioorg Med Chem
; 16(16): 7552-60, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18678497
18.
Identification of an (-)-englerin A analogue, which antagonizes (-)-englerin A at TRPC1/4/5 channels.
Br J Pharmacol
; 175(5): 830-839, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29247460
19.
Identification of Noncatalytic Lysine Residues from Allosteric Circuits via Covalent Probes.
ACS Chem Biol
; 13(5): 1307-1312, 2018 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29658704
20.
Gasdermin D plays a vital role in the generation of neutrophil extracellular traps.
Sci Immunol
; 3(26)2018 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30143555