Detalhe da pesquisa
1.
Discovery of novel pyridinones as MGAT2 inhibitors for the treatment of metabolic disorders.
Bioorg Med Chem Lett
; 91: 129362, 2023 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37295614
2.
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain.
J Pharmacol Exp Ther
; 358(3): 371-86, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27411717
3.
Inhibition by stabilization: targeting the Plasmodium falciparum aldolase-TRAP complex.
Malar J
; 14: 324, 2015 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-26289816
4.
Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists.
Bioorg Med Chem Lett
; 25(6): 1196-205, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25686852
5.
Carotid plaque inflammation on 18F-fluorodeoxyglucose positron emission tomography predicts early stroke recurrence.
Ann Neurol
; 71(5): 709-18, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22461139
6.
Discovery of 12 (BMS-986172) as a Highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a Low Human Dose for the Treatment of Metabolic Disorders.
J Med Chem
; 66(18): 13135-13147, 2023 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37724542
7.
Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132).
J Med Chem
; 65(5): 4291-4317, 2022 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35179904
8.
Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders.
J Med Chem
; 64(19): 14773-14792, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34613725
9.
Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation.
Bioorg Med Chem Lett
; 20(9): 2933-7, 2010 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20356736
10.
Gender-Related Differences in Flood Risk Perception and Behaviours among Private Groundwater Users in the Republic of Ireland.
Int J Environ Res Public Health
; 17(6)2020 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32245013
11.
Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage.
ACS Med Chem Lett
; 11(3): 266-271, 2020 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184955
12.
Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.
Bioorg Med Chem Lett
; 19(5): 1451-6, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19201606
13.
The management of mycotic femoral pseudoaneurysms in intravenous drug abusers.
Ann Vasc Surg
; 23(3): 345-9, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-18809282
14.
Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist.
J Pharmacol Exp Ther
; 327(3): 716-26, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18799592
15.
Design, synthesis, and structure-activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARalpha/gamma agonists.
Bioorg Med Chem Lett
; 18(12): 3545-50, 2008 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18511276
16.
Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists.
Bioorg Med Chem Lett
; 18(6): 1939-44, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18291645
17.
Things We Do for No Reason™: Routine pretreatment with a P2Y12 receptor inhibitor before invasive coronary angiography for patients with a non-ST elevation acute coronary syndrome.
J Hosp Med
; 18(2): 177-180, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35920593
18.
Screening for Peripheral Arterial Disease and Carotid Artery Disease in Patients With Abdominal Aortic Aneurysm.
Angiology
; 67(4): 346-9, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26056393
19.
Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist.
ACS Med Chem Lett
; 7(6): 590-4, 2016 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27326332
20.
Serum lipids associated with inflammation-related PET-FDG uptake in symptomatic carotid plaque.
Neurology
; 82(19): 1693-9, 2014 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24727313