Detalhe da pesquisa
1.
Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets.
J Am Chem Soc
; 145(44): 24035-24051, 2023 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37874670
2.
Integration of genetically regulated gene expression and pharmacological library provides therapeutic drug candidates.
Hum Mol Genet
; 30(3-4): 294-304, 2021 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33577681
3.
Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson's disease-related fibril polymorphism.
Acta Neuropathol
; 145(5): 573-595, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36939875
4.
Whole gut virome analysis of 476 Japanese revealed a link between phage and autoimmune disease.
Ann Rheum Dis
; 81(2): 278-288, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34880054
5.
Increased levels of plasma nucleotides in patients with rheumatoid arthritis.
Int Immunol
; 33(2): 119-124, 2021 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32866240
6.
Trans-Ethnic Fine-Mapping of the Major Histocompatibility Complex Region Linked to Parkinson's Disease.
Mov Disord
; 36(8): 1805-1814, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33973677
7.
A Mendelian randomization study identified obesity as a causal risk factor of uterine endometrial cancer in Japanese.
Cancer Sci
; 111(12): 4646-4651, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-32981178
8.
Integration of genetics and miRNA-target gene network identified disease biology implicated in tissue specificity.
Nucleic Acids Res
; 46(22): 11898-11909, 2018 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30407537
9.
Next-generation sequencing identifies contribution of both class I and II HLA genes on susceptibility of multiple sclerosis in Japanese.
J Neuroinflammation
; 16(1): 162, 2019 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31382992
10.
Optimization of the phenylurea moiety in a phosphoinositide 3-kinase (PI3K) inhibitor to improve water solubility and the PK profile by introducing a solubilizing group and ortho substituents.
Bioorg Med Chem
; 24(13): 2897-2906, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27189888
11.
Modification of a dihydropyrrolopyrimidine phosphoinositide 3-kinase (PI3K) inhibitor to improve oral bioavailability.
Bioorg Med Chem
; 23(24): 7650-60, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26613634
12.
A useful model capable of predicting the clearance of cytochrome 3A4 (CYP3A4) substrates in humans: validity of CYP3A4 transgenic mice lacking their own Cyp3a enzymes.
Drug Metab Dispos
; 42(9): 1540-7, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25005602
13.
Decreased hepatic enzymes reflect the decreased vitamin B6 levels in Parkinson's disease patients.
Pharmacol Res Perspect
; 12(1): e1174, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38287715
14.
Lead optimization of a dihydropyrrolopyrimidine inhibitor against phosphoinositide 3-kinase (PI3K) to improve the phenol glucuronic acid conjugation.
Bioorg Med Chem Lett
; 23(3): 673-8, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23265889
15.
A new approach to predicting human hepatic clearance of CYP3A4 substrates using monkey pharmacokinetic data.
Xenobiotica
; 43(5): 468-78, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23153054
16.
Neural correlates of impulsive compulsive behaviors in Parkinson's disease: A Japanese retrospective study.
Neuroimage Clin
; 37: 103307, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36586362
17.
Reconstruction of the personal information from human genome reads in gut metagenome sequencing data.
Nat Microbiol
; 8(6): 1079-1094, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37188815
18.
Analysis of gut microbiome, host genetics, and plasma metabolites reveals gut microbiome-host interactions in the Japanese population.
Cell Rep
; 42(11): 113324, 2023 11 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37935197
19.
Angiogenesis inhibitors identified by cell-based high-throughput screening: synthesis, structure-activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation.
Bioorg Med Chem
; 20(4): 1442-60, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22269278
20.
Cell type-specific abnormalities of central nervous system in myotonic dystrophy type 1.
Brain Commun
; 4(3): fcac154, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35770133