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1.
Sci Rep ; 11(1): 19553, 2021 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-34599232

RESUMO

Strontium and oxygen isotopes of individuals from El Hundido and Valdescusa (north of Spain) sites, corresponding to the Bell Beaker culture, were analysed in order to determine mobility patterns and provenance areas. Strontium and oxygen isotope ratios in three teeth from two individuals at El Hundido and two teeth from the five individuals at Valdescusa were studied. The analyses were performed in both dentine and enamel fractions. 87Sr/86Sr ratios of El Hundido individuals indicate one was of foreign origin and the other was local whereas at Valdescusa were all of foreign provenance. Calculated δ18Ow values of El Hundido suggest a provenance from the geographical area close to the site while the Valdescusa would come from a warmer region. The comparison of oxygen and strontium isotope signatures indicate the west of the Iberian Peninsula (Zamora or the east of Leon regions) as the provenance area for the foreign individual at El Hundido and southwest France (Garonne basin) as the region of provenance for the Valdescusa.


Assuntos
Antropologia , Migração Humana , Isótopos de Oxigênio , Isótopos de Estrôncio , Antropologia/métodos , Feminino , França , Geografia , Humanos , Masculino , Espanha , Dente/química
2.
Mar Pollut Bull ; 147: 16-35, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-29454492

RESUMO

Ballast water discharges may cause negative impacts to aquatic ecosystems, human health and economic activities by the introduction of potentially harmful species. Fifty untreated ballast water tanks, ten in each port, were sampled in four Adriatic Italian ports and one Slovenian port. Salinity, temperature and fluorescence were measured on board. Faecal indicator bacteria (FIB), phyto- and zooplankton were qualitatively and quantitatively determined to identify the species assemblage arriving in ballast water. FIB exceeded the convention standard limits in 12% of the sampled tanks. Vibrio cholerae was not detected. The number of viable organisms in the size groups (minimum dimension) <50 and ≥10 µm and ≥50 µm resulted above the abundances required from the Ballast Water Management Convention in 55 and 86% of the samples, respectively. This is not surprising as unmanaged ballast waters were sampled. Some potentially toxic and non-indigenous species were observed in both phyto- and zooplankton assemblages.


Assuntos
Fitoplâncton , Navios , Zooplâncton , Animais , Organismos Aquáticos , Bactérias , Ecossistema , Fezes/microbiologia , Espécies Introduzidas , Mar Mediterrâneo , Fitoplâncton/classificação , Salinidade , Inquéritos e Questionários , Temperatura , Água/química , Microbiologia da Água , Zooplâncton/classificação
3.
Thromb Haemost ; 73(3): 380-5, 1995 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-7667819

RESUMO

Pulmonary embolism (PE) is a serious complication following hip surgery. Trials of antiplatelet thromboprophylaxis indicated a substantial reduction in PE rate, and we prospectively studied the effect of a combination of low-dose heparin and two different antiplatelets. Furthermore, our experience in previous studies suggested that platelet count (PC) levels could be useful to reliably suspect PE at a very early stage, and we prospectively tried to confirm our previous findings. Ours is a prospective study in 459 consecutive patients operated on because of hip fracture (265) or elective hip replacement (194), aimed to determine: 1) whether the benefits of antiplatelets plus heparin on PE outweigh the risks; 2) to assess the clinical usefulness of PC monitoring in these patients, so as to confirm whether PE could be recognized early. It was a prospective, randomized, double-blind study. All patients received unfractioned heparin (7500 IU sc twice daily, starting 2 h before operation). In addition, they received aspirin (200 mg thrice daily, with meals), Triflusal (300 mg thrice daily, with meals), or placebo. Real time B-mode ultrasonography (US) was performed on all patients on the 8-9th day after surgery. Venography was performed in patients with normal US, if clinical symptoms suggested venous thrombosis. Twelve out of the 459 patients (2.6%) had to discontinue prophylaxis, because of major bleeding (6 patients), or gastric intolerance (6 patients). There were no significant differences between groups in either deep vein thrombosis (26 patients (18%) with aspirin, 18 (12%) with Triflusal, 26 (17%) with placebo), or PE development (7 patients (5%) with aspirin, 3 (2%) with Triflusal, 8 (5%) taking placebo).(ABSTRACT TRUNCATED AT 250 WORDS)


Assuntos
Aspirina/uso terapêutico , Fraturas do Quadril/cirurgia , Prótese de Quadril , Inibidores da Agregação Plaquetária/uso terapêutico , Contagem de Plaquetas , Complicações Pós-Operatórias/prevenção & controle , Embolia Pulmonar/prevenção & controle , Salicilatos/uso terapêutico , Idoso , Idoso de 80 Anos ou mais , Aspirina/efeitos adversos , Método Duplo-Cego , Quimioterapia Combinada , Feminino , Hemorragia/induzido quimicamente , Heparina/efeitos adversos , Heparina/uso terapêutico , Fraturas do Quadril/sangue , Humanos , Masculino , Pessoa de Meia-Idade , Inibidores da Agregação Plaquetária/efeitos adversos , Contagem de Plaquetas/efeitos dos fármacos , Complicações Pós-Operatórias/sangue , Complicações Pós-Operatórias/mortalidade , Estudos Prospectivos , Embolia Pulmonar/sangue , Embolia Pulmonar/diagnóstico por imagem , Embolia Pulmonar/mortalidade , Cintilografia , Salicilatos/efeitos adversos , Tromboflebite/sangue , Tromboflebite/diagnóstico por imagem , Tromboflebite/epidemiologia , Tromboflebite/prevenção & controle , Resultado do Tratamento , Ultrassonografia , Vômito/induzido quimicamente
4.
Chest ; 102(3): 677-81, 1992 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-1516386

RESUMO

The influence of several diseases and clinical conditions on the presence of pulmonary embolism (PE) in a large series of patients with deep venous thrombosis (DVT) in the lower extremities was analyzed prospectively. Lung scan findings from a series of 434 consecutive patients with DVT (with and without symptoms of PE) were studied and then correlated to five clinical variables: age, sex, elapsed time since clinical symptoms had appeared in the leg to diagnosis, degree of proximity of venous thrombus, and the presence or not of several risk factors that could have predisposed to thrombus development. According to scintigraphic findings, 164 patients were considered to have PE (asymptomatic in 76 of them), while 200 patients were classified as having only DVT. Lung scan was considered to be indeterminate for PE in 70 patients, and they were not included in the study. No differences were found in terms of age, sex, interval of time elapsed since onset of symptoms to diagnosis, or in the degree of proximity of the thrombus. However, several differences between groups were found when comparing the presence or absence of several predisposing factors for thrombosis: DVT developing in immobilized patients was associated with a significantly lower incidence of PE as compared with nonimmobilized patients (p = 0.005). Conversely, patients with a history of venous thromboembolism (VTE) had a significantly higher rate of embolism (31/51 vs 133/313; p = 0.01). On logistic regression analysis, a history of VTE showed a statistically significant association with more than a twofold higher risk of having PE for patients with such an antecedent. Our findings suggest that different pathophysiologic pathways could perhaps explain differences in embolic potential.


Assuntos
Embolia Pulmonar/epidemiologia , Tromboflebite/epidemiologia , Causalidade , Feminino , Humanos , Incidência , Perna (Membro)/irrigação sanguínea , Pulmão/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Flebografia , Estudos Prospectivos , Embolia Pulmonar/diagnóstico por imagem , Cintilografia , Análise de Regressão , Fatores de Risco , Tromboflebite/diagnóstico por imagem
5.
Chest ; 103(3): 816-9, 1993 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-8449074

RESUMO

We prospectively studied 78 consecutive patients with acute pulmonary embolism (PE) to determine the most appropriate workup study for searching for hidden cancer. After a careful physical examination, the following tests were performed: erythrocyte sedimentation rate (ESR), complete blood cell counts, biochemistry, carcinoembryonic antigen levels, chest radiograph, upper gastrointestinal endoscopy, and abdominal ultrasound. If a malignant lesion was suspected, further appropriate tests were performed. After hospital discharge, periodic follow-up was performed on all patients in our outpatient clinic. A malignant lesion was detected in 9 of 78 patients: in 7 of them, cancer was diagnosed during the hospital admission because of acute PE. All but one of these 7 patients were asymptomatic, except for PE symptoms. In three of them some abnormalities on physical examination led to the diagnosis of cancer; in the remaining three patients the diagnosis was suspected from abnormal results of blood tests. Cancer was detected several months after hospital discharge in two additional patients: an esophageal cancer was diagnosed 5 months later in one of the 23 patients who refused endoscopy; and a colonic carcinoma was detected 21 months after hospital discharge in a patient in whom colonoscopy was not performed at the time of hospital admission. When considered overall, cancer was more commonly found in patients with "idiopathic" PE as compared with patients with known risk factors for PE development (6 of 21 patients vs 3 of 51 patients; p < 0.05). On the other hand, one patient died because of massive recurrent PE after a biopsy sample was obtained because of a prostatic node. Gross hematuria had developed shortly after biopsy, and any attempt to increase heparin doses was followed by recurrent hematuria. According to our experience, any decision about procedures that potentially involve bleeding should be carefully individualized in patients with acute PE.


Assuntos
Neoplasias Primárias Desconhecidas/epidemiologia , Embolia Pulmonar/epidemiologia , Doença Aguda , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Primárias Desconhecidas/complicações , Neoplasias Primárias Desconhecidas/diagnóstico , Estudos Prospectivos , Embolia Pulmonar/diagnóstico , Embolia Pulmonar/etiologia , Reprodutibilidade dos Testes , Espanha/epidemiologia
6.
Urology ; 29(1): 95-8, 1987 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-3541350

RESUMO

A case of emphysematous pyelonephritis which was diagnosed by conventional radiology and confirmed by ultrasonography, computed tomography, and surgery is described. The etiology and pathogenesis of this severe infection are discussed, and the usefulness of the various noninvasive radiologic methods for the diagnosis and management of the infection is reviewed.


Assuntos
Pielonefrite/diagnóstico , Enfisema/etiologia , Feminino , Humanos , Pessoa de Meia-Idade , Pielonefrite/cirurgia , Tomografia Computadorizada por Raios X , Ultrassonografia
7.
Pancreas ; 1(6): 529-35, 1986.
Artigo em Inglês | MEDLINE | ID: mdl-3550789

RESUMO

Acute pancreatitis can be induced experimentally in rats by the retrograde pancreatic duct injection of deoxycholic acid. In order to evaluate if prostaglandins have a protective or therapeutic role, pancreatitis was induced with 0.03, 0.1, or 0.2 ml of 3% deoxycholic acid. Then, 16,16 dimethyl prostaglandin E2 or prostaglandin I2 were infused i.v. for 30 min before the deoxycholic acid injection or for 1 or 24 h beginning 30 min or 1 h after the injection. Deoxycholic acid, 0.1 and 0.2 ml, produced an 80-100% mortality at 24 h after the induction of pancreatitis, and prostaglandin administration had no appreciable effect. Induction of pancreatitis with 0.03 ml deoxycholic acid was associated with a 15% mortality at 24 h, and both prostaglandins significantly increased the mortality. In the experimental model of pancreatitis tested, the administration of exogenous PGI2 and 16,16 dimethyl PGE2 significantly worsened the outcome.


Assuntos
Epoprostenol/uso terapêutico , Pancreatite/tratamento farmacológico , Prostaglandinas E Sintéticas/uso terapêutico , Doença Aguda , Animais , Ácido Desoxicólico/toxicidade , Epoprostenol/efeitos adversos , Feminino , Pancreatite/induzido quimicamente , Prostaglandinas E Sintéticas/efeitos adversos , Ratos , Ratos Endogâmicos
8.
Eur J Radiol ; 7(3): 220-1, 1987 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-3653117

RESUMO

A case of thrombosis of the ascending right lumbar vein in a patient with infrahepatic interruption of the inferior vena cava and azygos-hemiazygos continuation is reported and the CT findings are described.


Assuntos
Vértebras Lombares/irrigação sanguínea , Trombose/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Veia Cava Inferior/anormalidades , Colecistectomia , Humanos , Masculino , Pessoa de Meia-Idade , Flebografia , Complicações Pós-Operatórias/diagnóstico por imagem , Tromboflebite/diagnóstico por imagem
9.
Med Clin (Barc) ; 117(9): 332-3, 2001 Sep 29.
Artigo em Espanhol | MEDLINE | ID: mdl-11749904

RESUMO

BACKGROUND: We aimed to find out whether systematic reading of chest radiography (CRx) by radiologists in the emergency unit might lead to a higher diagnostic efficiency and improve health care. MATERIAL AND METHOD: Descriptive study of consecutive admissions during 3 months in an internal medicine department. We registered the CRx interpretation by the emergency unit physician first, and a radiologist the next day. In cases with different interpretations, we assessed whether these differences would have modified the treatment. RESULTS: The overall disagreement between the emergency room physician and the radiologist was 13.7%. In 19 of 29 cases with different readings, the radiologist interpretation was in agreement with the final diagnosis. In 7 of these 19 cases, the radiologist reading of CRx would have led to a positive change of treatment. However, differences between both physicians were not statistically significant. CONCLUSIONS: There seems to be a higher diagnostic efficiency when the emergency room physician interpretation of CRx is complemented by a radiologist.


Assuntos
Serviço Hospitalar de Emergência , Hospitais Universitários , Radiografia Torácica/estatística & dados numéricos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Variações Dependentes do Observador , Médicos , Espanha
10.
An Med Interna ; 6(7): 361-5, 1989 Jul.
Artigo em Espanhol | MEDLINE | ID: mdl-2491491

RESUMO

The absorption of calcium pidolate is studied in 10 females suffering from osteoporosis by oral overload compared to the results of the glucono-lactate-carbonate. 405 mq of Ca pidolate produced a higher excretion of calcium by urine and an increase of Ca levels in blood than that produced by 1000 mq of Ca glucono-lactate-carbonate. The tolerance and the lack of side effects were the common feature in both salts. There were no effects on parathyroid glands nor bone resorption. We concluded that calcium pidolate is a safe and efficient treatment for osteoporosis because of easy absorption, which is very helpful in maintaining the calcium balance.


Assuntos
Carbonato de Cálcio/farmacocinética , Gluconato de Cálcio/farmacocinética , Cálcio/farmacocinética , Lactatos/farmacocinética , Osteoporose Pós-Menopausa/metabolismo , Ácido Pirrolidonocarboxílico/farmacocinética , Absorção , Idoso , Cálcio/uso terapêutico , Carbonato de Cálcio/uso terapêutico , Gluconato de Cálcio/uso terapêutico , Combinação de Medicamentos , Avaliação de Medicamentos , Tolerância a Medicamentos , Feminino , Humanos , Lactatos/uso terapêutico , Ácido Láctico , Pessoa de Meia-Idade , Osteoporose Pós-Menopausa/tratamento farmacológico , Ácido Pirrolidonocarboxílico/uso terapêutico
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