Improved outcome of orthotopic liver transplantation for chronic hepatitis B cirrhosis with aggressive passive immunization.

Passive immunization with hepatitis B surface antibody (anti-HBs) is important to prevent hepatitis B virus (HBV) recurrence after orthotopic liver transplantation for chronic HBV cirrhosis. Hepatitis B immune globulin (HBIG) dosing regimens have been poorly defined, utilize numerous routes of administration, and result in a high rate of HBV relapse and mortality. Twenty-five of 27 (93%) patients transplanted (four retransplants) for chronic HBV cirrhosis show no evidence of recurrent HBV (range, 2-55 months). Anti-HBs titers necessary to minimize the risk of hepatitis B surface antigen detectability were >500 IU/L for days 0 to 7, >250 IU/L for days 8 to 90, and >100 IU/L thereafter. Pretransplant HBV E antigen (HBeAG)-positive patients required more HBIG to achieve these goals than HBeAG-negative individuals. The elimination of anti-HBs changed continually for the initial 3 posttransplant months. The anti-HBs half-life increased from 0.7 days to 14.1 days. Anti-HBs elimination was significantly different in HBeAG+ and HBeAG- patients for the first week, but was subsequently indistinguishable after week 1. After 3 months, the half-life was statistically less for HBeAG+ patients, but the difference did not influence the clinical treatment regimens. Quantitative hepatitis B DNA levels did not predict the amount of HBIG required. HBV recurrence after orthotopic liver transplantation can be reduced by aggressive passive immunization. Pharmacokinetic analysis of anti-Hbs elimination can improve immunoglobulin therapy and prevent recurrence of clinical hepatitis.

Prevalence of sexual dysfunctions and correlated conditions in a sample of Brazilian women--results of the Brazilian study on sexual behavior (BSSB).

The objective of this study was to assess the prevalence and risk factors of female sexual dysfunctions across a selection of social groups. In all, 1219 women in the community, aged 18 y or older, answered a 38-question self-applicable questionnaire. Statistical analysis was performed using multivariate logistic regression. The average age was 35.6 y (s.d.=12.31) and the average number of sexual intercourses was 2.8 (s.d.=1.94) a week. At least one sexual dysfunction was reported by 49% of the women; lack of sexual desire (LSD) by 26.7%; pain during sexual intercourse (PSI) by 23.1% and orgasmic dysfunction (OD) by 21%. Women aged over 40 y represented an LSD and OD risk factor, whereas women aged over 25 y showed less likelihood of presenting PSI. The educational level was inversely correlated with the risk of LSD, OD and PSI. Depression and cardiopathies increased PSI occurrences and women with diabetes mellitus showed a higher probability of developing LSD and OD. In conclusion, almost half the women had at least one sexual dysfunction, and prevalence increased with age and lower educational levels. Preventive medical care for the female population, mainly for patients with chronic and/or degenerative diseases, considerably reduced the chances of sexual dysfunction.

Tricuspid endocarditis: a rare infectious complication of cardiac pacemaker in a patient with Chagas' disease--a case report.

Tricuspid endocarditis was diagnosed in a sixty-four-year-old patient with Chagas' disease who had a permanent cardiac pacemaker and whose generator had been replaced five months before an infection in the pocket. The pacing system was replaced by an epicardial one and the patient received antibiotics with good results.

[Re-evaluation of clinical and electroencephalographical criteria of brain death determination in the child]. / Reavaliação dos critérios clínicos e eletrencefalográficos de determinação da morte cerebral na criança.

A case is reported in which there was a return of the electroencephalogram after a period of more than 36 hours of electrocerebral silence. Electroencephalographic technique and instrumentation were in accordance with the recommendations of Silverman, Saunders, Schwab and Masland . The possibilities of hypothermia or drug overdosage, known to reversibly depress the electroencephalogram, were excluded in the related case. The return of EEG activity was preceded by improvement in neurological status. It is concluded that criteria accepted for the determination of brain death in adults should not be valid for children.

[Prevalence of constipation in school children]. / Prevalência de constipação intestinal em escolares do ciclo básico.

OBJECTIVE: To obtain the prevalence of constipation in school children, as chronic constipation is frequent among children attending our outpatient unit but only scarce data about community prevalence are available. METHODS: 1145 children of the two first school years (52.5% males, median age 8y 4mo) of 5 schools in underprivileged areas were evaluated. They answered a previously validated questionnaire, applied by specially trained students of a practical nurse school. Defecation of scybalous stools and/or straining / pain, usually, were used to characterize constipation, by a strict criterium. Soiling or fecal blood occurring as isolated symptoms were not included in the strict criterium, but were included in two other criteria. RESULTS: The prevalence of constipation was 25.1% for boys and 32.9% for girls, by the strict criterium, and was more frequent among girls (p<0.05). Constipated boys and girls presented, respectively, 30.5% e 31.8% of soiling and 14.6% and 25.7% of fecal blood. In addition 61 boys and 49 girls presented either soiling or fecal blood as isolated symptoms and increased the prevalence by the other criteria. CONCLUSIONS: The prevalence of constipation in the observed community was high. Due to the severity of the possible complications, this could be considered a public health problem.

Reavaliacao dos criterios clinicos e eletrencefalograficos de determinacao da morte cerebral na crianca. / Re-evalution of clinical and electroencephalographical criterion of brain death determination in the child

Descreve-se um caso de recuperacao temporaria de funcoes de SNC apos persistencia de coma profundo com apneia, midriase paralitica bilateral, arreatividade e silencio eletrico cerebral por cerca de 40 horas. O caso serve para dar enfase ao fato de que a determinacao da "morte cerebral" deve-se fundamentar na associacao de criterios e eletrencefalograficos. Por criterios clinicos ou eletrencefalograficos isolados o caso aqui descrito teria, ja nas primeiras 24 horas, cumprido os requisitos de determinacao da morte cerebral e, posivelmente, nao se teria observado o reaparecimento de atividade eletrica cerebral e reatividade clinica. Sugere-se que os criterios clinicos e eletrencefalograficos de determinacao da morte cerebral estabelecidos para o adulto nao sejam necessariamenvalidos para a crianca