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Blast injury is a very complex phenomenon and frequently results in multiple injuries. One method to investigate the consequences of blast injuries is with the use of living systems (animal models). The use of animals allows the examination and evaluation of injury mechanisms in a more controlled manner, allowing variables such as primary or secondary blast injury for example, to be isolated and manipulated as required. To ensure a degree of standardisation across the blast research community a set of guidelines which helps researchers navigate challenges of modelling blast injuries in animals is required. This paper describes the guidelines for Using Animal Models in Blast Injury Research developed by the NATO Health Factors and Medicine (HFM) Research Task Group 234.
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Pesquisa Biomédica/normas , Traumatismos por Explosões , Modelos Animais de Doenças , Animais , Guias como Assunto , Projetos de PesquisaRESUMO
Blast injuries are often caused by more than one mechanism, do not occur in isolation, and typically elicit a secondary multi-system response. Research efforts often do not separate blast injuries caused by blast waves from those caused by blunt force trauma and other mechanisms. 15 experts from nine different NATO nations developed in the HFM Research Task Group (RTG; HFM-234 (RTG)) 'Environmental Toxicology of Blast Exposures: Injury Metrics, Modelling, Methods and Standards' Guidelines for Conducting Epidemiological Studies of Blast Injury. This paper describes these guidelines, which are intended to provide blast injury researchers and clinicians with a basic set of recommendations for blast injury epidemiological study design and data collection that need to be considered and described when conducting prospective longitudinal studies of blast injury.
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Traumatismos por Explosões/epidemiologia , Projetos de Pesquisa Epidemiológica , Estudos Epidemiológicos , Guias como Assunto , HumanosRESUMO
Globally, efforts are underway to reduce anthropogenic greenhouse gas emissions and to adapt to climate change impacts at the local level. However, there is a poor understanding of the relationship between city strategies on climate change mitigation and adaptation and the relevant policies at national and European level. This paper describes a comparative study and evaluation of cross-national policy. It reports the findings of studying the climate change strategies or plans from 200 European cities from Austria, Belgium, Estonia, Finland, France, Germany, Ireland, Italy, Netherlands, Spain and the United Kingdom. The study highlights the shared responsibility of global, European, national, regional and city policies. An interpretation and illustration of the influences from international and national networks and policy makers in stimulating the development of local strategies and actions is proposed. It was found that there is no archetypical way of planning for climate change, and multiple interests and motivations are inevitable. Our research warrants the need for a multi-scale approach to climate policy in the future, mainly ensuring sufficient capacity and resource to enable local authorities to plan and respond to their specific climate change agenda for maximising the management potentials for translating environmental challenges into opportunities.
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Cidades , Mudança Climática , Formulação de Políticas , Europa (Continente) , Humanos , UrbanizaçãoRESUMO
OBJECTIVES: To analyze whether living close to a busy road would increase the risk of having cardiac disease and hypertension. STUDY DESIGN: Longitudinal cross-sectional study. METHODS: We used cross-sectional longitudinal questionnaire data from the RHINE study for Tartu in 2000/2001 and 2011/2012. Home addresses of the respondents were geocoded and traffic data obtained from annually conducted traffic counts in Tartu. Relationships between proximity to a busy road and self-reported cardiac disease and hypertension were analyzed with multiple logistic regression. RESULTS: In terms of total traffic (≥10,000 vehicles per day) within a 150-m zone of a busy road, the odds ratio (OR) for prevalence of cardiac disease was significant in 2000/2001 (1.91, 95% CI 1.15-3.16) and 2011/2012 (1.58, 95% CI 1.01-2.47). Prevalence of hypertension was significant only in 2011/2012 (1.61, 95% CI 1.08-2.39). In terms of heavy duty vehicle traffic (≥500 vehicles per day) within a 150-m zone in 2000/2001, the OR was 1.52 (95% CI 1.04-2.24) and 1.49 (95% CI 1.02-2.17) respectively for the prevalence of cardiac disease and hypertension. In 2011/2012 no significant relationship between heavy duty vehicle traffic and cardiac disease or hypertension was found. We also saw a significant relationship between total traffic and the onset of cardiac disease (OR = 2.04, 95% CI 1.07-3.87). CONCLUSIONS: This study showed that living closer than 150 m to a busy road can increase the odds of having cardiac disease and hypertension, which should be taken into account in city planning.
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Planejamento Ambiental/estatística & dados numéricos , Exposição Ambiental/efeitos adversos , Cardiopatias/epidemiologia , Hipertensão/epidemiologia , Características de Residência/estatística & dados numéricos , Emissões de Veículos/toxicidade , Adulto , Estudos Transversais , Estônia/epidemiologia , Feminino , Humanos , Modelos Logísticos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Razão de Chances , Prevalência , Medição de RiscoRESUMO
In order to develop climate resilient urban areas and reduce emissions, several opportunities exist starting from conscious planning and design of green (and blue) spaces in these landscapes. Green urban infrastructure has been regarded as beneficial, e.g. by balancing water flows, providing thermal comfort. This article explores the existing evidence on the contribution of green spaces to climate change mitigation and adaptation services. We suggest a framework of ecosystem services for systematizing the evidence on the provision of bio-physical benefits (e.g. CO2 sequestration) as well as social and psychological benefits (e.g. improved health) that enable coping with (adaptation) or reducing the adverse effects (mitigation) of climate change. The multi-functional and multi-scale nature of green urban infrastructure complicates the categorization of services and benefits, since in reality the interactions between various benefits are manifold and appear on different scales. We will show the relevance of the benefits from green urban infrastructures on three spatial scales (i.e. city, neighborhood and site specific scales). We will further report on co-benefits and trade-offs between the various services indicating that a benefit could in turn be detrimental in relation to other functions. The manuscript identifies avenues for further research on the role of green urban infrastructure, in different types of cities, climates and social contexts. Our systematic understanding of the bio-physical and social processes defining various services allows targeting stressors that may hamper the provision of green urban infrastructure services in individual behavior as well as in wider planning and environmental management in urban areas.
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Cidades , Mudança Climática , Ecossistema , Planejamento de Cidades , Fenômenos Ecológicos e Ambientais , Planejamento Ambiental , Humanos , Saúde da População UrbanaRESUMO
Climate change affects human health; however, there have been no large-scale, systematic efforts to quantify the heat-related human health impacts that have already occurred due to climate change. Here, we use empirical data from 732 locations in 43 countries to estimate the mortality burdens associated with the additional heat exposure that has resulted from recent human-induced warming, during the period 1991-2018. Across all study countries, we find that 37.0% (range 20.5-76.3%) of warm-season heat-related deaths can be attributed to anthropogenic climate change and that increased mortality is evident on every continent. Burdens varied geographically but were of the order of dozens to hundreds of deaths per year in many locations. Our findings support the urgent need for more ambitious mitigation and adaptation strategies to minimize the public health impacts of climate change.
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INTRODUCTION: Noise-induced hearing loss is one of the most common health problems among military service personnel. Exposure to noise in military vehicles constitutes a large proportion of total noise exposure. This pilot study aimed to evaluate in-vehicle noise levels depending on the type of vehicle, riding compartment and road surface. METHOD: Noise levels were measured in armoured personnel carriers and heavy all-terrain trucks, in the cab and rear passenger compartment, while driving on paved or off-road surfaces. The results were compared with national LLV and allowed noise exposure times were calculated per vehicle and surface. RESULTS: The equivalent noise levels in the cab of SISU XA-188 (p=0.001) and peak noise levels in MAN 4620 (p=0.0001) and DAF 4440 (p=0.0047) were higher on paved road, compared with off-road. The equivalent noise levels in the canvas covered rear compartment of MAN 4620 were significantly higher than in the cab on both paved (p=0.004) and off-road (p=0.0003). Peak noise levels in the cab of DAF 4440 exceeded the parameters measured in the canvas covered rear compartment on both paved (p=0.002) and off-road (p=0.0002). In most cases, peak noise levels were below the LLV (p=0.02-0.0001). The maximum noise exposure to passengers in the canvas covered rear compartment of MAN 4620 despite road surface was calculated 0.6 hours per working day. CONCLUSION: A high risk of noise-induced hearing loss among military personnel occurs during long distance transportation with vehicles showing noise levels higher than allowed LLV.
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Militares/estatística & dados numéricos , Veículos Automotores/estatística & dados numéricos , Ruído Ocupacional/efeitos adversos , Adulto , Audiometria/métodos , Humanos , Masculino , Veículos Automotores/classificação , Ruído Ocupacional/estatística & dados numéricos , Projetos PilotoRESUMO
OBJECTIVES: Exposure to air pollutants in the ambient environment has been associated with various respiratory symptoms, and with increased asthma diagnosis, in both children and adults. Most research to date has focussed on core pollutants, such as PM10, PM2.5, SO2 and NO2, and less attention has been given to the effects of industry-specific contamination. The current study aimed to examine the associations between respiratory symptoms, asthma, increased levels of fractional exhaled nitric oxide (FeNO) (as a marker of eosinophilic airway inflammation) and ambient levels of industrial pollutants (such as benzene, phenol, formaldehyde and non-methane hydrocarbons) for schoolchildren living near oil shale industries in Ida-Viru County, Estonia. METHODS: A total of 1326 schoolchildren from Ida-Viru, Lääne-Viru and Tartu Counties participated in a cross-sectional study, consisting of questionnaires on respiratory symptoms and asthma, as well as clinical examinations to measure FeNO. Dispersion modelling was used to characterize individual-level exposure to industrial air pollutants at each subject's home address. Associations between exposure and respiratory health were investigated using logistic regression analysis, and differences in results between regions were analysed using the Chi-squared test. RESULTS: The prevalence of respiratory symptoms (pâ¯<â¯0.05) in children living near (i.e. within 5â¯km) of an oil shale industry site in Ida-Viru County was 2-4 times higher than in children living in the reference area of Tartu County. Children exposed to 1⯵g/m3 higher levels of benzene and formaldehyde had a higher odds ratio (OR) of having rhinitis without a cold (OR 1.03, 95% confidence interval (CI) 1.01-1.06), of ever having had attacks of asthma (OR 1.05, 95% CI 1.01-1.10) and of having a dry cough a few days per year (OR 1.05, 95% CI 1.01-1.10). Children exposed to 1⯵g/m3 higher levels of benzene, formaldehyde, phenol and non-methane hydrocarbons had a higher odds ratio of having high FeNO levels (≥30â¯ppb): OR and 95% CI of 1.05, 1.01-1.09; 1.22, 1.06-1.41; 1.01, 1.00-1.01; and 1.75, 1.75-2.62, respectively.
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Poluentes Atmosféricos/análise , Exposição Ambiental , Formaldeído/análise , Hidrocarbonetos/análise , Óxido Nítrico/análise , Doenças Respiratórias/epidemiologia , Asma/induzido quimicamente , Asma/epidemiologia , Criança , Estudos Transversais , Monitoramento Ambiental , Estônia/epidemiologia , Expiração , Feminino , Humanos , Masculino , Indústria de Petróleo e Gás , Prevalência , Doenças Respiratórias/induzido quimicamenteRESUMO
PURPOSE OF REVIEW: Air pollution significantly affects health, causing up to 7 million premature deaths annually with an even larger number of hospitalizations and days of sick leave. Climate change could alter the dispersion of primary pollutants, particularly particulate matter, and intensify the formation of secondary pollutants, such as near-surface ozone. The purpose of the review is to evaluate the recent evidence on the impacts of climate change on air pollution and air pollution-related health impacts and identify knowledge gaps for future research. RECENT FINDINGS: Several studies modelled future ozone and particulate matter concentrations and calculated the resulting health impacts under different climate scenarios. Due to climate change, ozone- and fine particle-related mortalities are expected to increase in most studies; however, results differ by region, assumed climate change scenario and other factors such as population and background emissions. This review explores the relationships between climate change, air pollution and air pollution-related health impacts. The results highly depend on the climate change scenario used and on projections of future air pollution emissions, with relatively high uncertainty. Studies primarily focused on mortality; projections on the effects on morbidity are needed.