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Mar Drugs ; 13(10): 6425-39, 2015 Oct 20.
Artigo em Inglês | MEDLINE | ID: mdl-26492255

RESUMO

Sulfated polysaccharides produced by microalgae, which are known to exhibit various biological activities, may potentially serve as natural antioxidant sources. To date, only a few studies have examined the antioxidant bioactivity of red microalgal polysaccharides. In this research, the effect of different salts on the antioxidant activities of two red microalgal sulfated polysaccharides derived from Porphyridium sp. and Porphyridium aerugineum were studied in a soy bean-based infant milk formula. Salt composition and concentration were both shown to affect the polysaccharides' antioxidant activity. It can be postulated that the salt ions intefer with the polysaccharide chains' interactions and alter their structure, leading to a new three-dimensional structure that better exposes antiooxidant sites in comparison to the polysaccharide without salt supplement. Among the cations that were studied, Ca(2+) had the strongest enhancement effect on antioxidant activities of both polysaccharides. Understanding the effect of salts on polysaccharides' stucture, in addition to furthering knowledge on polysaccharide bioactivities, may also shed light on the position of the antioxidant active sites.


Assuntos
Antioxidantes/farmacologia , Microalgas/metabolismo , Polissacarídeos/farmacologia , Porphyridium/metabolismo , Antioxidantes/isolamento & purificação , Cálcio/química , Humanos , Lactente , Fórmulas Infantis/química , Polissacarídeos/química , Polissacarídeos/isolamento & purificação , Sais/química , Glycine max/química , Sulfatos/química , Sulfatos/isolamento & purificação , Sulfatos/farmacologia
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