Detalhe da pesquisa
1.
Pathogenic Aß production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1.
J Biol Chem
; 299(8): 104997, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37394008
2.
The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-ß generation.
J Biol Chem
; 288(4): 2521-31, 2013 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23209290
3.
Substrate determinants in the C99 juxtamembrane domains differentially affect γ-secretase cleavage specificity and modulator pharmacology.
J Neurochem
; 125(4): 610-9, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23253155
4.
O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies.
ACS Chem Neurosci
; 13(8): 1296-1314, 2022 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35357812
5.
Development and characterization of a novel membrane assay for full-length BACE-1 at pH 6.0.
J Biomol Screen
; 18(3): 277-85, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23023105
6.
Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400.
FEBS Lett
; 587(22): 3722-8, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24113653