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Doenças Musculoesqueléticas , Lesões do Manguito Rotador , Tendinopatia , Humanos , Manguito Rotador/diagnóstico por imagem , Prevalência , Tendinopatia/diagnóstico por imagem , Tendinopatia/epidemiologia , Neovascularização Patológica/diagnóstico por imagem , Neovascularização Patológica/epidemiologia , Ultrassonografia DopplerRESUMO
STUDY DESIGN: Cross-sectional, controlled study. OBJECTIVE: To evaluate the sciatic nerves of subjects with spinal cord injury (SCI) by using ultrasound (US) imaging and to explore whether US measurements are associated with clinical and electrophysiological findings. SETTING: National Rehabilitation Center in Ankara, Turkey. METHODS: Fifteen SCI subjects (12 male (M), 3 female (F)) and 23 (16 M, 7 F) healthy controls were included in the study. After clinical assessment of the subjects, lower limb nerve conduction studies and US imaging of the sciatic nerves were performed. Cross-sectional area (CSA) values of the sciatic nerves were correlated with the clinical and electrophysiologic data. RESULTS: Mean CSA values were lower in the patient group when compared with the control group (P=0.042). Reduced compound motor action potentials regarding tibial and peroneal nerves were observed in the patient group (P=0.003 and P=0.005, respectively). US measurements did not correlate with the electrophysiological findings. However, sciatic nerve CSA values were positively correlated with body mass index in the control (r=0.534, P<0.05) and patient (r=0.482, P<0.05) groups. CONCLUSION: Sciatic nerves seem to be smaller in subjects with SCI. Together with our electrophysiological data, this preliminary finding could possibly be attributed to primary axonal loss.
Assuntos
Potenciais de Ação/fisiologia , Condução Nervosa/fisiologia , Nervo Isquiático/diagnóstico por imagem , Nervo Isquiático/fisiopatologia , Traumatismos da Medula Espinal/patologia , Adulto , Eletromiografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , UltrassonografiaRESUMO
Thoracic outlet syndrome (TOS) is a challenging clinical condition with regards to its diagnosis and treatment. Its management may turn out to be challenging a case when an adverse complication such as Paget-Schroetter syndrome (PSS) also co-exists. Herein, we report a nine-year follow-up of a patient with TOS (a 41-year old cardiovascular surgeon) who had suffered multiple PSS episodes and repeat TOS surgeries. In essence, we want to highlight the diverse clinical indings of TOS and discuss its management in light of the relevant literature.
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OBJECTIVE: The study aimed to assess tendon thickness in patients with chronic occupational lead exposure by using ultrasonography. METHODS: Twenty-seven male workers (mean age 32.9 ± 6.2 years, range 25-44 years) with occupational lead exposure and 27 age- and body mass index (BMI)-matched healthy male subjects (mean age 33.1 ± 5.6 years, range 25-44 years) were enrolled. Ultrasonographic measurements were obtained from the supraspinatus and Achilles tendons by using a linear probe (5-10 MHz). RESULTS: Mean Achilles tendon values at long axis (p = 0.034) and tendon cross-sectional area (p = 0.013) were significantly smaller in the lead-exposed group than the control group. On the other hand, no significant difference was found regarding the thickness of the supraspinatus tendon (p > 0.05). CONCLUSION: Our preliminary results imply that subjects with occupational lead exposure have smaller Achilles tendons than healthy subjects. Chronic lead exposure may affect the tendons due to reduction of collagen synthesis. Further studies are definitely needed to confirm our initial findings.
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OBJECTIVE: To evaluate femoral cartilage thickness in patients with Behçet's disease (BD) by using ultrasonography. METHODS: Thirty-one patients with BD (18 M, 13 F; mean age: 32.87 ± 8.5 years) and 31 age-, gender- and body mass index-matched healthy subjects were enrolled. Demographic features and medications of the patients were recorded. The femoral cartilage thicknesses of both knees were measured with a 7-12 MHz linear probe while subjects' knees were held in maximum flexion. Three mid-point measurements were taken from both knees: lateral femoral condyle (LFC), intercondylar area (ICA) and medial femoral condyle (MFC). RESULTS: Cartilage measurements of BD patients were significantly thinner at the ICA (p = 0.009) and LFC (p = 0.007) on the left knee, and at the MFC on both sides (both p < 0.05). Left knee cartilage thickness value at MFC (p = 0.005) was decreased in BD patients with arthritis compared to the healthy control group. CONCLUSION: These preliminary findings of decreased femoral cartilage thickness in BD patients with arthritis should be complemented with future studies. However, the possibility of early knee joint degeneration and eventual osteoarthritis in BD should also be kept in mind.
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OBJECTIVE: To evaluate femoral cartilage thickness in patients with ankylosing spondylitis (AS) by using ultrasonography. METHODS: Eighty-four patients (55 M, 29 F) with a diagnosis of AS and 84 age-, gender- and body mass index-matched healthy subjects were enrolled. Demographic and clinical characteristics of the patients including disease duration, morning stiffness and medications were recorded. The femoral cartilage thicknesses of both knees were measured with a 7-12 MHz linear probe while subjects' knees were held in maximum flexion. Three mid-point measurements were taken from both knees (lateral femoral condyle (LFC), intercondylar area (ICA) and medial femoral condyle (MFC)). RESULTS: Concerning both ICA (p < 0.001) and left MFC (p = 0.013), cartilage measurements were significantly thicker in AS patients than control subjects. In a subgroup analysis (anti-tumour necrosis factor (TNF) users vs anti-TNF naive), cartilage thickness measurements - bilateral ICA (p = 0.000) and left MFC (p = 0.017) - were found to be greater in AS patients under anti-TNF treatment (n = 65) when compared with those of healthy controls. CONCLUSION: We imply that AS patients seem to have thicker femoral cartilage, which could be related to anti-TNF treatment.
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Toxinas Botulínicas , Transtornos de Enxaqueca , Fármacos Neuromusculares , Humanos , InjeçõesRESUMO
The use of whole body vibration (WBV) for therapeutic purposes is far from being standardized and the training protocols reported in the literature vary considerably. Currently, the optimal threshold for a beneficial effect is undetermined, and caution regarding potential health risks due to WBV is always necessary. In this case report, we present a 34-year-old otherwise healthy elite athlete (steeplechase runner) who suffered two episodes of hematuria (HT) after WBV training. Shortly after the third WBV, he had an episode of bright red urine. Seven days later, following the next WBV session (and again before his daily running session), a reddish-colored urine reappeared. Our patient was advised to stop WBV training and to take fluid before and during exertion. He did not experience any episode of HT during a 1-year follow-up with periodic check-ups, in spite of the continuation of his sporting career. The concomitance of the two types of trauma - daily running and WBV - could have been critical in this case for producing HT. In particular, we think that platforms providing side-alternating vibration (such as the Galileo platform) may pose some health risks if the feet are positioned too far from the axis of rotation.
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Hematúria/etiologia , Corrida , Vibração/efeitos adversos , Adulto , Humanos , MasculinoRESUMO
STUDY DESIGN: Cross-sectional controlled study. OBJECTIVES: To evaluate the elbow joint with ultrasound in paraplegic patients, determine the related factors and compare it with healthy controls. SETTING: A training and research rehabilitation hospital in Istanbul. METHODS: A total of 30 paraplegic patients and 20 healthy controls were included in the study. Patients demographic data, pain in the elbow joint, level and duration of injury, ambulation status, type of wheelchair used, daily duration of wheelchair and other ambulation equipment usage, transfers being dependent or independent, daily number of push-ups were recorded. Elbow joints were evaluated with ultrasound for presence of fluid and thickness of the triceps tendon. RESULTS: Mean triceps tendon thickness values of the right side were larger in spinal cord injury (SCI) patients when compared with those of healthy controls'. Joint effusion on the right elbow joint was also found to be more common in SCI patients than in normal subjects. Triceps tendon thickness measurements were not found to be correlated with demographic and clinical factors. Seven paraplegic patients (23%) reported that they have pain in the elbow. CONCLUSION: In this preliminary study, our results showed that right elbow effusion was more frequent and right triceps tendon was thicker in SCI patients when compared with healthy subjects.
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Articulação do Cotovelo/diagnóstico por imagem , Articulação do Cotovelo/patologia , Paraplegia/etiologia , Paraplegia/patologia , Traumatismos da Medula Espinal/complicações , Adulto , Idoso , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Tendões/diagnóstico por imagem , Tendões/patologia , Ultrassonografia , Adulto JovemAssuntos
Hanseníase/diagnóstico por imagem , Artrite/diagnóstico por imagem , Seguimentos , Humanos , Doenças da Unha/diagnóstico por imagem , Doenças do Sistema Nervoso/diagnóstico por imagem , Osteíte/diagnóstico por imagem , Periostite/diagnóstico por imagem , Dermatopatias Bacterianas/diagnóstico por imagem , UltrassonografiaRESUMO
Alveolar bone destruction can be magnified in the presence of generalized skeletal disorders. We questioned whether severe generalized periodontitis patients display signs of bone metabolism disturbances. Our objective was to assess skeletal bone mineral density (BMD) and biochemical bone parameters in premenopausal women with periodontitis. Forty-five patients and 40 control individuals were included in the study. We measured BMD by dual-energy x-ray absorptiometry. The results showed no difference in BMD values between the periodontitis and control groups (p > 0.05). A positive relationship between the clinical attachment level and Body Mass Index (BMI) scores was observed (p = 0.03). Increased serum creatinine levels were noted in the periodontitis group (p = 0.04). Analysis of the data suggests that there is no evidence for an association between skeletal BMD and severe periodontitis in premenopausal women. There may be a link between elevated creatinine levels and periodontitis. The persons with high BMI scores seemed to be at risk for periodontitis.
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Densidade Óssea/fisiologia , Periodontite/fisiopatologia , Pré-Menopausa/fisiologia , Absorciometria de Fóton , Adulto , Análise Química do Sangue , Índice de Massa Corporal , Creatinina/sangue , Cálculos Dentários/fisiopatologia , Índice de Placa Dentária , Feminino , Hemorragia Gengival/fisiopatologia , Articulação do Quadril , Humanos , Vértebras Lombares , Pessoa de Meia-Idade , Perda da Inserção Periodontal/fisiopatologia , Índice Periodontal , Bolsa Periodontal/fisiopatologia , Periodontite/sangue , Fatores de Risco , Perda de Dente/fisiopatologiaRESUMO
OBJECTIVE: Familial Mediterranean fever (FMF) is the most common auto-inflammatory syndrome with exaggerated acute phase and inflammatory response. After revealing the MEFV gene mutation with the finally disturbed end product pyrin, some of the mechanisms were explained. However it is still unknown what triggers or ends these periodical attacks. Moreover, the treatment of up to 30% of the patients, that are resistant to colchicine is still a problem. In this study we investigated the role of serotonin in colchicine-resistant FMF patients. METHODS: Twenty-four FMF patients (male/female: 15/9) and 32 age- and sex-matched healthy controls (male/female: 17/15) were included into the study. Patients were subdivided into two groups. Thirteen had FMF attacks despite regular colchicine (colchicine-resistant group), other 11 had disease under control with colchicine for at least 6-months. Sampling was done both during the attack and ten days after its cessation. Plasma and platelet serotonin levels and acute phase reactants were studied in patients and controls. RESULTS: Colchicine-resistant patients had plasma serotonin (5-HT) levels of 7.85 +/- 1.0 nmol/l during acute attacks which significantly reduced to the levels of 6.3 +/- 0.6 nmol/l (p < 0.001), after 10 days of acute attacks and these levels were significantly lower than those of attack-free patients' and controls' (10.7 +/- 0.2 nmol/l and 10.1 +/- 0.3 nmol/l, respectively). Platelet 5-HT level was 6.4 +/- 0.3 nmol/10(9) platelets during acute attack, and this level was increased to 9.8 +/- 0.5 nmol/10(9) platelets on the 2(nd) sampling, 10 days after the cessation of the acute attack (p < 0.001). They were both significantly higher than those of attack-free FMF patients (5.9 +/- 0.1 nmol/10(9) platelets) and healthy controls (5.7 +/- 0.3 nmol/10(9) platelets). There was a negative correlation between plasma and platelet 5-HT levels (r=-0.77, p < 0.001). CONCLUSION: Changes in plasma and platelet 5-HT levels may be related to the disturbances in 5-HT transport mechanisms or may also be attributed to the potential role of serotonin in the inflammatory cascade. Last but not least, serotonin may have a role in the pathogenesis of FMF.
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Plaquetas/efeitos dos fármacos , Resistência a Medicamentos/efeitos dos fármacos , Febre Familiar do Mediterrâneo/sangue , Febre Familiar do Mediterrâneo/tratamento farmacológico , Inibidores Seletivos de Recaptação de Serotonina/farmacologia , Serotonina/sangue , Adolescente , Adulto , Estudos de Casos e Controles , Colchicina/farmacologia , Resistência a Medicamentos/fisiologia , Feminino , Supressores da Gota/farmacologia , Humanos , Inflamação/sangue , Inflamação/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Proteínas da Membrana Plasmática de Transporte de Serotonina/efeitos dos fármacosRESUMO
Joint cracking involves a manipulation of the finger joints resulting in an audible crack. This study aimed to determine whether habitual knuckle cracking (KC) leads to an alteration in grip strength and metacarpal head (MH) cartilage thickness. Thirty-five habitual knuckle crackers (cracking their joints ≥5times/day) (20 M, 15 F, aged 19-27 years) and 35 age-, gender-, and body mass index-matched non-crackers were enrolled in the study. MH cartilage thickness was measured with ultrasound and grip strength was measured with an analog Jamar hand dynamometer. Grip strength was similar between groups (P>0.05). Habitual knuckle crackers had thicker MH cartilage in the dominant and non-dominant hands than those of the controls (P=0.038 and P=0.005, respectively). There was no correlation between MH cartilage thickness and grip strength in both groups (P>0.05). While habitual KC does not affect handgrip strength, it appears to be associated with increased MH cartilage thickness.