Pesquisa | BVS Violência e Saúde

1.

Sensitizing protective tumor microenvironments to antibody-mediated therapy.

Pallasch, Christian P; Leskov, Ilya; Braun, Christian J; Vorholt, Daniela; Drake, Adam; Soto-Feliciano, Yadira M; Bent, Eric H; Schwamb, Janine; Iliopoulou, Bettina; Kutsch, Nadine; van Rooijen, Nico; Frenzel, Lukas P; Wendtner, Clemens M; Heukamp, Lukas; Kreuzer, Karl Anton; Hallek, Michael; Chen, Jianzhu; Hemann, Michael T.

Cell ; 156(3): 590-602, 2014 Jan 30.

Artigo em Inglês | MEDLINE | ID: mdl-24485462

2.

Extracellular vesicles and PD-L1 suppress macrophages, inducing therapy resistance in TP53-deficient B-cell malignancies.

Izquierdo, Elena; Vorholt, Daniela; Blakemore, Stuart; Sackey, Benedict; Nolte, Janica L; Barbarino, Verena; Schmitz, Jan; Nickel, Nadine; Bachurski, Daniel; Lobastova, Liudmila; Nikolic, Milos; Michalik, Michael; Brinker, Reinhild; Merkel, Olaf; Franitza, Marek; Georgomanolis, Theodoros; Neuhaus, René; Koch, Maximilian; Nasada, Niklas; Knittel, Gero; Chapuy, Björn; Ludwig, Nicole; Meese, Eckart; Frenzel, Lukas; Reinhardt, Hans Christian; Peifer, Martin; Rebollido-Rios, Rocio; Bruns, Heiko; Krüger, Marcus; Hallek, Michael; Pallasch, Christian P.

Blood ; 139(25): 3617-3629, 2022 06 23.

Artigo em Inglês | MEDLINE | ID: mdl-35344582

3.

Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy.

Nettersheim, Felix Sebastian; Schlüter, Johannes David; Kreuzberg, Wiebke; Mehrkens, Dennis; Grimm, Simon; Nemade, Harshal; Braumann, Simon; Hof, Alexander; Guthoff, Henning; Peters, Vera; Hoyer, Friedrich Felix; Kargapolova, Yulia; Lackmann, Jan-Wilm; Müller, Stefan; Pallasch, Christian P; Hallek, Michael; Sachinidis, Agapios; Adam, Matti; Winkels, Holger; Baldus, Stephan; Geißen, Simon; Mollenhauer, Martin.

Basic Res Cardiol ; 118(1): 36, 2023 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-37656254

4.

Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1.

Kohlhaas, Vivien; Blakemore, Stuart James; Al-Maarri, Mona; Nickel, Nadine; Pal, Martin; Roth, Andreas; Hövelmeyer, Nadine; Schäfer, Stephan C; Knittel, Gero; Lohneis, Philipp; Nikolic, Milos; Wiederstein, Janica L; Franitza, Marek; Georgomonolis, Theodoros; Reinart, Nina; Herling, Marco; Herling, Carmen; Hartmann, Elena M; Rosenwald, Andreas; Klapper, Wolfram; Büttner, Reinhard; Moia, Riccardo; Rossi, Davide; Boldorini, Renzo; Gaidano, Gianluca; Frenzel, Lukas P; Reinhardt, Hans Christian; Brüning, Jens C; Hallek, Michael; Krüger, Marcus; Peifer, Martin; Pallasch, Christian P; Wunderlich, F Thomas.

Blood ; 137(5): 646-660, 2021 02 04.

Artigo em Inglês | MEDLINE | ID: mdl-33538798

5.

Kinase activity profiling reveals contribution of G-protein signaling modulator 2 deficiency to impaired regulatory T cell migration in rheumatoid arthritis.

Meyer, Anja; Yan, Shuaifeng; Golumba-Nagy, Viktoria; Esser, Ruth L; Barbarino, Verena; Blakemore, Stuart J; Rusyn, Lisa; Nikiforov, Anastasia; Seeger-Nukpezah, Tamina; Grüll, Holger; Pallasch, Christian P; Kofler, David M.

J Autoimmun ; 124: 102726, 2021 11.

Artigo em Inglês | MEDLINE | ID: mdl-34555678

6.

Tumor Metabolism as a Regulator of Tumor-Host Interactions in the B-Cell Lymphoma Microenvironment-Fueling Progression and Novel Brakes for Therapy.

Beielstein, Anna C; Pallasch, Christian P.

Int J Mol Sci ; 20(17)2019 Aug 26.

Artigo em Inglês | MEDLINE | ID: mdl-31454887

7.

Cell cycle control in Richter transformation.

Pallasch, Christian P.

Blood ; 138(12): 1005-1007, 2021 09 23.

Artigo em Inglês | MEDLINE | ID: mdl-34554222

8.

miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL.

Berg, Valeska; Rusch, Marion; Vartak, Nachiket; Jüngst, Christian; Schauss, Astrid; Waldmann, Herbert; Hedberg, Christian; Pallasch, Christian P; Bastiaens, Philippe I H; Hallek, Michael; Wendtner, Clemens-Martin; Frenzel, Lukas P.

Blood ; 125(19): 2948-57, 2015 May 07.

Artigo em Inglês | MEDLINE | ID: mdl-25670628

9.

Rewired NFκB signaling as a potentially actionable feature of activated B-cell-like diffuse large B-cell lymphoma.

Knittel, Gero; Liedgens, Paul; Korovkina, Darya; Pallasch, Christian P; Reinhardt, Hans Christian.

Eur J Haematol ; 97(6): 499-510, 2016 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-27526684

10.

B-cell receptor triggers drug sensitivity of primary CLL cells by controlling glucosylation of ceramides.

Schwamb, Janine; Feldhaus, Valeska; Baumann, Michael; Patz, Michaela; Brodesser, Susanne; Brinker, Reinhild; Claasen, Julia; Pallasch, Christian P; Hallek, Michael; Wendtner, Clemens-Martin; Frenzel, Lukas P.

Blood ; 120(19): 3978-85, 2012 Nov 08.

Artigo em Inglês | MEDLINE | ID: mdl-22927247

11.

Functional impact and molecular binding modes of drugs that target the PI3K isoform p110Î´.

Hassenrück, Floyd; Farina-Morillas, Maria; Neumann, Lars; Landini, Francesco; Blakemore, Stuart James; Rabipour, Mina; Alvarez-Idaboy, Juan Raul; Pallasch, Christian P; Hallek, Michael; Rebollido-Rios, Rocio; Krause, Günter.

Commun Biol ; 6(1): 603, 2023 06 05.

Artigo em Inglês | MEDLINE | ID: mdl-37277510

12.

Transcriptomic profiles and 5-year results from the randomized CLL14 study of venetoclax plus obinutuzumab versus chlorambucil plus obinutuzumab in chronic lymphocytic leukemia.

Al-Sawaf, Othman; Zhang, Can; Jin, Hyun Yong; Robrecht, Sandra; Choi, Yoonha; Balasubramanian, Sandhya; Kotak, Alex; Chang, Yi Meng; Fink, Anna Maria; Tausch, Eugen; Schneider, Christof; Ritgen, Matthias; Kreuzer, Karl-Anton; Chyla, Brenda; Paulson, Joseph N; Pallasch, Christian P; Frenzel, Lukas P; Peifer, Martin; Eichhorst, Barbara; Stilgenbauer, Stephan; Jiang, Yanwen; Hallek, Michael; Fischer, Kirsten.

Nat Commun ; 14(1): 2147, 2023 04 18.

Artigo em Inglês | MEDLINE | ID: mdl-37072421

13.

Detection of a novel truncating Merkel cell polyomavirus large T antigen deletion in chronic lymphocytic leukemia cells.

Pantulu, N Deepa; Pallasch, Christian P; Kurz, Anna Kordelia; Kassem, Ahmad; Frenzel, Lukas; Sodenkamp, Sebastian; Kvasnicka, Hans Michael; Wendtner, Clemens M; Zur Hausen, Axel.

Blood ; 116(24): 5280-4, 2010 Dec 09.

Artigo em Inglês | MEDLINE | ID: mdl-20817850

14.

Sustained NF-kappaB activity in chronic lymphocytic leukemia is independent of genetic and epigenetic alterations in the TNFAIP3 (A20) locus.

Frenzel, Lukas P; Claus, Rainer; Plume, Nadine; Schwamb, Janine; Konermann, Carolin; Pallasch, Christian P; Claasen, Julia; Brinker, Reinhild; Wollnik, Bernd; Plass, Christoph; Wendtner, Clemens-Martin.

Int J Cancer ; 128(10): 2495-500, 2011 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-20669229

15.

Novel X-linked inhibitor of apoptosis inhibiting compound as sensitizer for TRAIL-mediated apoptosis in chronic lymphocytic leukaemia with poor prognosis.

Frenzel, Lukas P; Patz, Michaela; Pallasch, Christian P; Brinker, Reinhild; Claasen, Julia; Schulz, Alexandra; Hallek, Michael; Kashkar, Hamid; Wendtner, Clemens-Martin.

Br J Haematol ; 152(2): 191-200, 2011 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-21091905

16.

The kinase inhibitor dasatinib induces apoptosis in chronic lymphocytic leukemia cells in vitro with preference for a subgroup of patients with unmutated IgVH genes.

Veldurthy, Aditya; Patz, Michaela; Hagist, Susanne; Pallasch, Christian P; Wendtner, Clemens-Martin; Hallek, Michael; Krause, Günter.

Blood ; 112(4): 1443-52, 2008 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-18550857

17.

Macrophage-Mediated Antibody Dependent Effector Function in Aggressive B-Cell Lymphoma Treatment is Enhanced by Ibrutinib via Inhibition of JAK2.

Barbarino, Verena; Henschke, Sinika; Blakemore, Stuart James; Izquierdo, Elena; Michalik, Michael; Nickel, Nadine; Möllenkotte, Indra; Vorholt, Daniela; Müller, Linda; Brinker, Reinhild; Fedorchenko, Oleg; Mikhael, Nelly; Seeger-Nukpezah, Tamina; Hallek, Michael; Pallasch, Christian P.

Cancers (Basel) ; 12(8)2020 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-32824276

18.

Mechanisms of Lymphoma Clearance Induced by High-Dose Alkylating Agents.

Lossos, Chen; Liu, Yunpeng; Kolb, Kellie E; Christie, Amanda L; Van Scoyk, Alexandria; Prakadan, Sanjay M; Shigemori, Kay; Stevenson, Kristen E; Morrow, Sara; Plana, Olivia D; Fraser, Cameron; Jones, Kristen L; Liu, Huiyun; Pallasch, Christian P; Modiste, Rebecca; Nguyen, Quang-De; Craig, Jeffrey W; Morgan, Elizabeth A; Vega, Francisco; Aster, Jon C; Sarosiek, Kristopher A; Shalek, Alex K; Hemann, Michael T; Weinstock, David M.

Cancer Discov ; 9(7): 944-961, 2019 07.

Artigo em Inglês | MEDLINE | ID: mdl-31040105

19.

Lenalidomide enhances MOR202-dependent macrophage-mediated effector functions via the vitamin D pathway.

Busch, Leonhard; Mougiakakos, Dimitrios; Büttner-Herold, Maike; Müller, Miriam J; Volmer, Dietrich A; Bach, Christian; Fabri, Mario; Bittenbring, Jörg T; Neumann, Frank; Boxhammer, Rainer; Nolting, Jens; Bisht, Savita; Böttcher, Martin; Jitschin, Simon; Hoffmann, Markus H; Balzer, Heidi; Beier, Fabian; Gezer, Deniz; Dudziak, Diana; Gelse, Kolja; Hennig, Friedrich F; Pallasch, Christian P; Spriewald, Bernd; Mackensen, Andreas; Bruns, Heiko.

Leukemia ; 32(11): 2445-2458, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-29654274

20.

Author Correction: Transcriptomic profiles and 5-year results from the randomized CLL14 study of venetoclax plus obinutuzumab versus chlorambucil plus obinutuzumab in chronic lymphocytic leukemia.