RESUMO
The relationship between smoking and depression is bidirectional. Recent research has focused on nicotine's neurobiologic impact on the brain as it relates to depression. Genetic factors are also important and may account for up to 67% of smoking initiation, maintenance, and dependence. Because nicotine withdrawal may mimic and induce depression, appropriate clinical evaluation and treatment are essential to reduce the high morbidity and mortality associated with smoking and depression and maximize smoking cessation rates.
Assuntos
Depressão/etiologia , Fumar/psicologia , Adolescente , Adulto , Idoso , Antidepressivos/uso terapêutico , Depressão/genética , Depressão/prevenção & controle , Humanos , Nicotina/metabolismo , Nicotina/farmacologia , Agonistas Nicotínicos/metabolismo , Agonistas Nicotínicos/farmacologia , Fatores de Risco , Fumar/genética , Fumar/fisiopatologia , Abandono do Hábito de Fumar/métodos , Abandono do Hábito de Fumar/psicologiaRESUMO
Quetiapine is a medication approved for the treatment of psychotic disorders in adults. At this time it is not approved for the treatment of children or adolescents. It is an atypical antipsychotic agent that is efficacious in treating both the positive and negative symptoms of schizophrenia. There is currently little information available concerning the safety of quetiapine in overdose, and there are no previous case reports of quetiapine overdose in the pediatric population. We present the case of a 15-year-old girl who ingested 1250 mg of quetiapine (21.6 mg/kg) in a suicide attempt. She developed multiple symptoms including tachycardia, agitation, hypotension, and unconsciousness. We compare her symptoms to previous adult cases of quetiapine overdose and review overdose treatment recommendations. We also examine clinical situations that may lead to a more severe clinical course.