RESUMO
We evaluated the epithelializing-promoting effect of a concentration of 0.005 mg/ml murine epidermal growth factor (mEGF), topically administered four times daily, on the herpes simplex virus 1 (HSV-1) corneal ulcers of the rabbit eye. The severity of the herpetic lesions was evaluated clinically, after the time course of the severity of epithelial keratitis, conjunctivitis, iritis, and stromal disease, for 14 days. A histological assessment was performed in the middle and at the end of the follow-up. The stromal keratitis of the mEGF-treated group was significantly more severe than the keratitis exhibited by the placebo-treated rabbits (Y = X3 X2*X4; p = 0.0001). There were no significant differences in the degree of conjunctivitis, epithelial keratitis, iritis, and virus shedding between these groups. No evidence of a toxic effect of mEGF or placebo was found in the mock infected rabbit eyes. More studies, using different herpes virus strains and a broad range of murine and human EGF concentrations, are mandatory to ascertain the general significance of these results. Meanwhile, caution is recommended when using mEGF in the presence of an occult or manifest herpetic eye disease.
Assuntos
Substância Própria/microbiologia , Fator de Crescimento Epidérmico/farmacologia , Ceratite Herpética/microbiologia , Administração Tópica , Animais , Substância Própria/patologia , Modelos Animais de Doenças , Fator de Crescimento Epidérmico/efeitos adversos , Herpesvirus Humano 1/fisiologia , Camundongos , Coelhos , Distribuição Aleatória , Células Vero , Eliminação de Partículas ViraisRESUMO
We report a case of a benign villous adenoma of the prostatic urethra causing urethral obstruction in a 45-year-old man. Villous adenoma of the prostatic urethra is rare. Hematuria was the presenting sign in most reported cases. However, some lesions were discovered unexpectedly on endoscopic examinations for the assessment of lower urinary tract disease. Villous adenoma of the urethra is composed of prostatic type tissue. The presence of the PSA marker in its epithelium indicates a common embryologic origin with the prostate.
Assuntos
Adenoma/diagnóstico , Coristoma/diagnóstico , Doenças Prostáticas/diagnóstico , Doenças Uretrais/diagnóstico , Obstrução Uretral/etiologia , Adenoma/patologia , Adenoma/cirurgia , Coristoma/patologia , Coristoma/cirurgia , Hematúria , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Prostáticas/patologia , Doenças Prostáticas/cirurgia , Doenças Uretrais/patologia , Doenças Uretrais/cirurgiaRESUMO
The use of ureteral stents to assure continuity and patency of the upper urinary tract has become common in endo-urology. We present an 82-year-old bedridden woman with hydronephrosis and pseudomonas sepsis. Because of ureteropelvic junction stenosis a stent was inserted. Shortly thereafter the stent fragmented spontaneously into 5 pieces. The importance of being familiar with endo-urological manipulations and their complications is emphasized.