Adenosine deaminase in body fluids: a useful diagnostic tool in tuberculosis.

The performance of a colorimetric ADA determination in body fluids other than serum in the diagnosis of tuberculosis was assessed in 1063 patients from whom pleural (600), peritoneal (136), pericardial (77), or cerebrospinal (250) fluids were obtained. In exudative pleuroperitoneal and pericardial effusions, an ADA decision level of 0.71 mu kat/L displayed a sensitivity of 1.00, and was higher than those of histologic (0.83) and bacteriologic (0.62) studies. At this level, ADA reached a specificity of 0.92 and efficiency of 0.94. In cerebrospinal fluid, an ADA catalytic concentration above 0.15 mu kat/L strongly suggests tuberculous meningitis in patients older than 7 years (sensitivity 1.00, specificity 0.99 and efficiency 0.99). ADA results obtained with a UV-method were closely correlated with those of the colorimetric method in pleuroperitoneal effusions (r = 0.989) and in cerebrospinal fluids (r = 0.905). Sample blanks should be processed, otherwise false positive results may be found in non-tuberculous cerebrospinal fluids (5.3%) and pleuroperitoneal effusions (3.8%).

Improvement of emergency and routine turnaround time by data processing and instrumentation changes.

A retrospective study of stat and routine laboratory analysis turnaround time was performed in a 1000-bed public hospital before and after the implementation of instrument and computer changes. Significant decreases in turnaround time were found for enzyme tests in the stat laboratory and for all analytes studied in the routine laboratory. The decrease in TAT was evaluated using a physician satisfaction scale, elaborated in conjunction with specialists from several fields, that disclosed an increase in perceptive quality. Results from other authors and recommendations by the College of American Pathologists for turnaround time are discussed.

[Epidural vs. intradural anesthesia in ambulatory surgery]. / Anestesia epidural frente a anestesia intradural en cirugía ambulatoria.

Spinal anesthesia is the technique of choice for many outpatient procedures. With appropriate screening and preparation, it can provide excellent surgical conditions and highly satisfactory anesthesia for the patient, while remaining cost-effective. Intradural anesthesia has advantages over epidural anesthesia: technical simplicity, rapid onset, efficacy and depth of blockade. Its use has been controversial, however, for many years due to the potential risk of headache after puncture of the dura mater. Epidural anesthesia causes fewer hemodynamic changes and provides greater dose flexibility and local anesthetic concentration, with less risk of headache after accidental puncture of the dura mater. The drawbacks are that it takes longer to perform and onset of blockade comes later. Both techniques are valid alternatives to general anesthesia in outpatient surgery. The choice of one over the other will depend on patient characteristics, availability of a presurgical area, and the anesthesiologist's skill.

[Evaluation of anesthetic techniques in ambulatory surgery]. / Evaluación de las técnicas anestésicas en cirugía ambulatoria.

Many of the surgical procedures performed in the hospital can be done on an out-patient basis, provided an appropriate anesthetic technique is applied to allow the patient to return home comfortably and safely. Choice of anesthetic technique must always be made in keeping with patient characteristics and type of surgery. Treatment of anxiety in a preoperative interview or by giving tranquilizers will be beneficial to all patients, as will reduction of gastric secretion by administration of H2 receptor blockers. Dehydrobenzoperidol at a dose of 0.5 to 1.125 mg in adults will antagonize the emetic effects of opioids, without prolonging recovery time. Propofol, alfentanyl, atracurium or vecuronium require the shortest recovery time. For epidural anesthesia, we use lidocaine and mepivacaine. Truncal blocks, endovenous regional anesthesia, and brachial plexus, retrobulbar and peribulbar blocks are all appropriate techniques for out-patient surgery.