Detalhe da pesquisa
1.
MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape.
Mol Cell
; 82(6): 1140-1155.e11, 2022 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35245435
2.
The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia.
Nature
; 615(7954): 920-924, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36922593
3.
MEN1 mutations mediate clinical resistance to menin inhibition.
Nature
; 615(7954): 913-919, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36922589
4.
Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A-r and NPM1c AML.
Blood
; 143(15): 1513-1527, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38096371
5.
Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.
Nature
; 588(7836): 157-163, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33239784
6.
Histone PTM Crosstalk Stimulates Dot1 Methyltransferase Activity.
Trends Biochem Sci
; 46(7): 522-524, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33879367
7.
The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML.
Blood
; 139(6): 894-906, 2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34582559
8.
PLCG1 is required for AML1-ETO leukemia stem cell self-renewal.
Blood
; 139(7): 1080-1097, 2022 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34695195
9.
Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia.
Mol Cancer
; 22(1): 196, 2023 12 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38049829
10.
Contribution of clonal hematopoiesis to adult-onset hemophagocytic lymphohistiocytosis.
Blood
; 136(26): 3051-3055, 2020 12 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32961550
11.
Plasma VCAM1 levels correlate with disease severity in Parkinson's disease.
J Neuroinflammation
; 16(1): 94, 2019 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31068198
12.
Dysregulation of chemokine receptor expression and function in leukocytes from ALS patients.
J Neuroinflammation
; 15(1): 99, 2018 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29592817
13.
Novel inhibitors of the histone methyltransferase DOT1L show potent antileukemic activity in patient-derived xenografts.
Blood
; 136(17): 1983-1988, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32575123
14.
Kinetics matter: prognostic implications of early bone marrow assessment in acute myeloid leukemia.
Haematologica
; 107(8): 1741-1742, 2022 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34758611
15.
Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia.
Cancer Discov
; 13(3): 746-765, 2023 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36455613
16.
A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition.
Cancer Discov
; 13(1): 146-169, 2023 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36264143
17.
Histone demethylase KDM4C is a functional dependency in JAK2-mutated neoplasms.
Leukemia
; 36(7): 1843-1849, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35654819
18.
IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia.
Nat Cancer
; 3(5): 595-613, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35534777
19.
YBX1 mediates translation of oncogenic transcripts to control cell competition in AML.
Leukemia
; 36(2): 426-437, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34465866
20.
Expression and function of ABC-transporter protein ABCB1 correlates with inhibitory capacity of Ruxolitinib in vitro and in vivo.
Haematologica
; 101(3): e81-5, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26589910