Detalhe da pesquisa
1.
Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants.
Hum Mol Genet
; 33(4): 355-373, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37944084
2.
Classification of missense variants in the N-methyl-d-aspartate receptor GRIN gene family as gain- or loss-of-function.
Hum Mol Genet
; 32(19): 2857-2871, 2023 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37369021
3.
De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor.
Cell Mol Life Sci
; 81(1): 153, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38538865
4.
Three-dimensional missense tolerance ratio analysis.
Genome Res
; 31(8): 1447-1461, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34301626
5.
Functional effects of disease-associated variants reveal that the S1-M1 linker of the NMDA receptor critically controls channel opening.
Cell Mol Life Sci
; 80(4): 110, 2023 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37000222
6.
Clinical and functional consequences of GRIA variants in patients with neurological diseases.
Cell Mol Life Sci
; 80(11): 345, 2023 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37921875
7.
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Pharmacol Rev
; 73(4): 298-487, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34753794
8.
Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis.
Mol Pharmacol
; 103(1): 21-37, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36384958
9.
Differential responses of disease-related GRIN variants located in pore-forming M2 domain of N-methyl-D-aspartate receptor to FDA-approved inhibitors.
J Neurochem
; 2023 Aug 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37649269
10.
De novo CLPTM1 variants with reduced GABAA R current response in patients with epilepsy.
Epilepsia
; 64(11): 2968-2981, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37577761
11.
Opportunities for Precision Treatment of GRIN2A and GRIN2B Gain-of-Function Variants in Triheteromeric N-Methyl-D-Aspartate Receptors.
J Pharmacol Exp Ther
; 381(1): 54-66, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35110392
12.
Biased modulators of NMDA receptors control channel opening and ion selectivity.
Nat Chem Biol
; 16(2): 188-196, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31959964
13.
Automated Intracellular Pharmacological Electrophysiology for Ligand-Gated Ionotropic Receptor and Pharmacology Screening.
Mol Pharmacol
; 100(1): 73-82, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33958481
14.
The Negative Allosteric Modulator EU1794-4 Reduces Single-Channel Conductance and Ca2+ Permeability of GluN1/GluN2A N-Methyl-d-Aspartate Receptors.
Mol Pharmacol
; 99(5): 399-411, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33688039
15.
Hodgkin-Huxley-Katz Prize Lecture: Genetic and pharmacological control of glutamate receptor channel through a highly conserved gating motif.
J Physiol
; 598(15): 3071-3083, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32468591
16.
GluN2D-Containing N-methyl-d-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity.
Mol Pharmacol
; 90(6): 689-702, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27625038
17.
A novel class of negative allosteric modulators of NMDA receptor function.
Bioorg Med Chem Lett
; 25(23): 5583-8, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26525866
18.
Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry.
Neuropsychopharmacology
; 49(1): 51-66, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37369776
19.
Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-D-aspartate receptors.
Mol Pharmacol
; 84(1): 114-27, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23625947
20.
Development of a Dihydroquinoline-Pyrazoline GluN2C/2D-Selective Negative Allosteric Modulator of the N-Methyl-d-aspartate Receptor.
ACS Chem Neurosci
; 14(17): 3059-3076, 2023 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37566734