1.
Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity.
Bioorg Med Chem Lett
; 22(12): 4028-32, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22579486
RESUMO
A new class of PDF inhibitor with potent, broad spectrum antibacterial activity is described. Optimization of blood stability and potency provided compounds with improved pharmacokinetics that were suitable for in vivo experiments. Compound 5c, which has robust antibacterial activity, demonstrated efficacy in two respiratory tract infection models.