Detalhe da pesquisa
1.
Validation of a diet-induced Macaca fascicularis model of non-alcoholic steatohepatitis with dietary and pioglitazone interventions.
Diabetes Obes Metab
; 25(4): 1068-1079, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36546607
2.
Drug Development in Kidney Disease: Proceedings From a Multistakeholder Conference.
Am J Kidney Dis
; 76(6): 842-850, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32768631
3.
Intrahepatic fat, irrespective of ethnicity, is associated with reduced endogenous insulin clearance and hepatic insulin resistance in obese youths: A cross-sectional and longitudinal study from the Yale Pediatric NAFLD cohort.
Diabetes Obes Metab
; 22(9): 1628-1638, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32363679
4.
Effect of canagliflozin treatment on hepatic triglyceride content and glucose metabolism in patients with type 2 diabetes.
Diabetes Obes Metab
; 21(4): 812-821, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30447037
5.
Potent Sodium/Glucose Cotransporter SGLT1/2 Dual Inhibition Improves Glycemic Control Without Marked Gastrointestinal Adaptation or Colonic Microbiota Changes in Rodents.
J Pharmacol Exp Ther
; 365(3): 676-687, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29674332
6.
Dissection of hepatic versus extra-hepatic insulin clearance: Ethnic differences in childhood.
Diabetes Obes Metab
; 20(12): 2869-2875, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30019375
7.
Intra- and inter-subject variability for increases in serum ketone bodies in patients with type 2 diabetes treated with the sodium glucose co-transporter 2 inhibitor canagliflozin.
Diabetes Obes Metab
; 20(5): 1321-1326, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29341404
8.
Pharmacokinetics and pharmacodynamics of canagliflozin in pediatric patients with type 2 diabetes.
Pediatr Diabetes
; 19(4): 649-655, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29271103
9.
Dynamic population pharmacokinetic-pharmacodynamic modelling and simulation supports similar efficacy in glycosylated haemoglobin response with once or twice-daily dosing of canagliflozin.
Br J Clin Pharmacol
; 83(5): 1072-1081, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28138980
10.
Effects of canagliflozin on body weight and relationship to HbA1c and blood pressure changes in patients with type 2 diabetes.
Diabetologia
; 58(6): 1183-7, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25813214
11.
Alteration of the glucagon axis in GPR120 (FFAR4) knockout mice: a role for GPR120 in glucagon secretion.
J Biol Chem
; 289(22): 15751-63, 2014 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-24742677
12.
Single- and multiple-dose pharmacokinetics and pharmacodynamics of canagliflozin, a selective inhibitor of sodium glucose co-transporter 2, in healthy participants.
Int J Clin Pharmacol Ther
; 53(2): 129-38, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25500487
13.
Pharmacokinetics and pharmacodynamics of once- and twice-daily multiple-doses of canagliflozin, a selective inhibitor of sodium glucose co-transporter 2, in healthy participants.
Int J Clin Pharmacol Ther
; 53(6): 438-46, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25907176
14.
Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves model-based indices of beta cell function in patients with type 2 diabetes.
Diabetologia
; 57(5): 891-901, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24585202
15.
Impaired decline in renal threshold for glucose during pregnancy - a possible novel mechanism for gestational diabetes mellitus.
Diabetes Metab Res Rev
; 30(2): 140-5, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24106177
16.
Optimal back-extrapolation method for estimating plasma volume in humans using the indocyanine green dilution method.
Theor Biol Med Model
; 11: 33, 2014 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25052018
17.
Role of Glycosuria in SGLT2 Inhibitor-Induced Cardiorenal Protection: A Mechanistic Analysis of the CREDENCE Trial.
Diabetes
; 73(2): 250-259, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37939214
18.
A long-acting GDF15 analog causes robust, sustained weight loss and reduction of food intake in an obese nonhuman primate model.
Clin Transl Sci
; 16(8): 1431-1444, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37154518
19.
Influence of adiposity, insulin resistance, and intrahepatic triglyceride content on insulin kinetics.
J Clin Invest
; 130(6): 3305-3314, 2020 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32191646
20.
Hepatic Insulin Extraction in NAFLD Is Related to Insulin Resistance Rather Than Liver Fat Content.
J Clin Endocrinol Metab
; 104(5): 1855-1865, 2019 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30566676