Detalhe da pesquisa
1.
Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief.
Proc Natl Acad Sci U S A
; 120(22): e2220979120, 2023 05 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37216510
2.
Mice expressing fluorescent PAR2 reveal that endocytosis mediates colonic inflammation and pain.
Proc Natl Acad Sci U S A
; 119(6)2022 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35110404
3.
Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain.
Proc Natl Acad Sci U S A
; 117(26): 15281-15292, 2020 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32546520
4.
A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes.
J Biol Chem
; 296: 100345, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33515548
5.
Contributions of bile acids to gastrointestinal physiology as receptor agonists and modifiers of ion channels.
Am J Physiol Gastrointest Liver Physiol
; 322(2): G201-G222, 2022 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34755536
6.
Positive allosteric modulation of endogenous delta opioid receptor signaling in the enteric nervous system is a potential treatment for gastrointestinal motility disorders.
Am J Physiol Gastrointest Liver Physiol
; 322(1): G66-G78, 2022 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34755545
7.
Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice.
Lab Invest
; 101(7): 851-864, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33859334
8.
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.
Proc Natl Acad Sci U S A
; 115(31): E7438-E7447, 2018 07 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30012612
9.
Protein kinase D and Gßγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2.
J Biol Chem
; 294(27): 10649-10662, 2019 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31142616
10.
The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability.
Lab Invest
; 100(8): 1057-1067, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32341518
11.
G-Protein-Coupled Receptors Are Dynamic Regulators of Digestion and Targets for Digestive Diseases.
Gastroenterology
; 156(6): 1600-1616, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30771352
12.
Agonist-dependent development of delta opioid receptor tolerance in the colon.
Cell Mol Life Sci
; 76(15): 3033-3050, 2019 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-30904952
13.
Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission.
Proc Natl Acad Sci U S A
; 114(46): 12309-12314, 2017 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29087309
14.
G protein-coupled receptor trafficking and signaling: new insights into the enteric nervous system.
Am J Physiol Gastrointest Liver Physiol
; 316(4): G446-G452, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30702900
15.
Clathrin and GRK2/3 inhibitors block δ-opioid receptor internalization in myenteric neurons and inhibit neuromuscular transmission in the mouse colon.
Am J Physiol Gastrointest Liver Physiol
; 317(2): G79-G89, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31091149
16.
G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease.
J Immunol
; 198(9): 3565-3575, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28320832
17.
Inflammation-associated changes in DOR expression and function in the mouse colon.
Am J Physiol Gastrointest Liver Physiol
; 315(4): G544-G559, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29927325
18.
The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation.
Pharmacol Rev
; 67(1): 36-73, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25361914
19.
Protein Kinase D and Gßγ Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane.
J Biol Chem
; 291(21): 11285-99, 2016 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27030010
20.
Synergistic effect of IL-12 and IL-18 induces TIM3 regulation of γδ T cell function and decreases the risk of clinical malaria in children living in Papua New Guinea.
BMC Med
; 15(1): 114, 2017 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28615061