Pesquisa | BVS Violência e Saúde

1.

Ferroptosis: A flexible constellation of related biochemical mechanisms.

Dixon, Scott J; Pratt, Derek A.

Mol Cell ; 83(7): 1030-1042, 2023 04 06.

Artigo em Inglês | MEDLINE | ID: mdl-36977413

2.

7-Dehydrocholesterol is an endogenous suppressor of ferroptosis.

Freitas, Florencio Porto; Alborzinia, Hamed; Dos Santos, Ancély Ferreira; Nepachalovich, Palina; Pedrera, Lohans; Zilka, Omkar; Inague, Alex; Klein, Corinna; Aroua, Nesrine; Kaushal, Kamini; Kast, Bettina; Lorenz, Svenja M; Kunz, Viktoria; Nehring, Helene; Xavier da Silva, Thamara N; Chen, Zhiyi; Atici, Sena; Doll, Sebastian G; Schaefer, Emily L; Ekpo, Ifedapo; Schmitz, Werner; Horling, Aline; Imming, Peter; Miyamoto, Sayuri; Wehman, Ann M; Genaro-Mattos, Thiago C; Mirnics, Karoly; Kumar, Lokender; Klein-Seetharaman, Judith; Meierjohann, Svenja; Weigand, Isabel; Kroiss, Matthias; Bornkamm, Georg W; Gomes, Fernando; Netto, Luis Eduardo Soares; Sathian, Manjima B; Konrad, David B; Covey, Douglas F; Michalke, Bernhard; Bommert, Kurt; Bargou, Ralf C; Garcia-Saez, Ana; Pratt, Derek A; Fedorova, Maria; Trumpp, Andreas; Conrad, Marcus; Friedmann Angeli, José Pedro.

Nature ; 626(7998): 401-410, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38297129

3.

A non-canonical vitamin K cycle is a potent ferroptosis suppressor.

Mishima, Eikan; Ito, Junya; Wu, Zijun; Nakamura, Toshitaka; Wahida, Adam; Doll, Sebastian; Tonnus, Wulf; Nepachalovich, Palina; Eggenhofer, Elke; Aldrovandi, Maceler; Henkelmann, Bernhard; Yamada, Ken-Ichi; Wanninger, Jonas; Zilka, Omkar; Sato, Emiko; Feederle, Regina; Hass, Daniela; Maida, Adriano; Mourão, André Santos Dias; Linkermann, Andreas; Geissler, Edward K; Nakagawa, Kiyotaka; Abe, Takaaki; Fedorova, Maria; Proneth, Bettina; Pratt, Derek A; Conrad, Marcus.

Nature ; 608(7924): 778-783, 2022 08.

Artigo em Inglês | MEDLINE | ID: mdl-35922516

4.

vPIF-1 is an insulin-like antiferroptotic viral peptide.

Belavgeni, Alexia; Maremonti, Francesca; Tonnus, Wulf; Stadtmüller, Marlena; Gavali, Shubhangi; Mallais, Melodie; Flade, Karolin; Brucker, Anne; Becker, Jorunn Naila; Beer, Kristina; Tmava, Mirela; Stumpf, Julian; Gembardt, Florian; Hugo, Christian; Giacca, Mauro; Hale, Benjamin G; Perakakis, Nikolaos; Sha, Wei; Pratt, Derek A; Schally, Andrew V; Bornstein, Stefan R; Linkermann, Andreas.

Proc Natl Acad Sci U S A ; 120(21): e2300320120, 2023 05 23.

Artigo em Inglês | MEDLINE | ID: mdl-37186845

5.

FSP1 is a glutathione-independent ferroptosis suppressor.

Doll, Sebastian; Freitas, Florencio Porto; Shah, Ron; Aldrovandi, Maceler; da Silva, Milene Costa; Ingold, Irina; Goya Grocin, Andrea; Xavier da Silva, Thamara Nishida; Panzilius, Elena; Scheel, Christina H; Mourão, André; Buday, Katalin; Sato, Mami; Wanninger, Jonas; Vignane, Thibaut; Mohana, Vaishnavi; Rehberg, Markus; Flatley, Andrew; Schepers, Aloys; Kurz, Andreas; White, Daniel; Sauer, Markus; Sattler, Michael; Tate, Edward William; Schmitz, Werner; Schulze, Almut; O'Donnell, Valerie; Proneth, Bettina; Popowicz, Grzegorz M; Pratt, Derek A; Angeli, José Pedro Friedmann; Conrad, Marcus.

Nature ; 575(7784): 693-698, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-31634899

6.

Interrupted Homolytic Substitution Enables Organoboron Compounds to Inhibit Radical Chain Reactions Rather than Initiate Them.

Wu, Zijun; Vlaming, Robynne; Donohoe, Michael; Pratt, Derek A.

J Am Chem Soc ; 146(1): 1153-1166, 2024 Jan 10.

Artigo em Inglês | MEDLINE | ID: mdl-38156607

7.

Revisiting the Reactivity of the Dismissed Hydrogen Atom Transfer Catalyst Succinimide-N-oxyl.

Yang, Cheng; Farmer, Luke A; Pratt, Derek A; Maldonado, Stephen; Stephenson, Corey R J.

J Am Chem Soc ; 146(18): 12511-12518, 2024 May 08.

Artigo em Inglês | MEDLINE | ID: mdl-38669671

8.

Non-Tertiary Alkyl Substituents Enhance High-Temperature Radical Trapping by Phenothiazine and Phenoxazine Antioxidants.

Farmer, Luke A; Pratt, Derek A.

J Org Chem ; 89(9): 6126-6137, 2024 May 03.

Artigo em Inglês | MEDLINE | ID: mdl-38619817

9.

Attenuating N-Oxyl Decomposition for Improved Hydrogen Atom Transfer Catalysts.

Yang, Cheng; Farmer, Luke A; McFee, Elvis C; Jha, Rahul Kant; Maldonado, Stephen; Pratt, Derek A; Stephenson, Corey R J.

Angew Chem Int Ed Engl ; 63(21): e202315917, 2024 May 21.

Artigo em Inglês | MEDLINE | ID: mdl-38437456

10.

A compendium of kinetic modulatory profiles identifies ferroptosis regulators.

Conlon, Megan; Poltorack, Carson D; Forcina, Giovanni C; Armenta, David A; Mallais, Melodie; Perez, Marcos A; Wells, Alex; Kahanu, Alexis; Magtanong, Leslie; Watts, Jennifer L; Pratt, Derek A; Dixon, Scott J.

Nat Chem Biol ; 17(6): 665-674, 2021 06.

Artigo em Inglês | MEDLINE | ID: mdl-33686292

11.

Enhancement of Diarylamine Antioxidant Activity by Molybdenum Dithiocarbamates.

Hanson, Carly S; Donohoe, Michael; Pratt, Derek A.

J Org Chem ; 88(24): 17420-17429, 2023 Dec 15.

Artigo em Inglês | MEDLINE | ID: mdl-38051117

12.

Leveraging the Persistent Radical Effect in the Synthesis of trans-2,3-Diaryl Dihydrobenzofurans.

Roldan, Bec J; Hammerstad, Travis A; Galliher, Matthew S; Keylor, Mitchell H; Pratt, Derek A; Stephenson, Corey R J.

Angew Chem Int Ed Engl ; 62(34): e202305801, 2023 Aug 21.

Artigo em Inglês | MEDLINE | ID: mdl-37390358

13.

Hydropersulfides Inhibit Lipid Peroxidation and Protect Cells from Ferroptosis.

Wu, Zijun; Khodade, Vinayak S; Chauvin, Jean-Philippe R; Rodriguez, Deborah; Toscano, John P; Pratt, Derek A.

J Am Chem Soc ; 144(34): 15825-15837, 2022 08 31.

Artigo em Inglês | MEDLINE | ID: mdl-35977425

14.

Intrinsic and Extrinsic Limitations to the Design and Optimization of Inhibitors of Lipid Peroxidation and Associated Cell Death.

Farmer, Luke A; Wu, Zijun; Poon, Jia-Fei; Zilka, Omkar; Lorenz, Svenja M; Huehn, Stephanie; Proneth, Bettina; Conrad, Marcus; Pratt, Derek A.

J Am Chem Soc ; 144(32): 14706-14721, 2022 08 17.

Artigo em Inglês | MEDLINE | ID: mdl-35921655

15.

Publisher Correction: The chemical basis of ferroptosis.

Conrad, Marcus; Pratt, Derek A.

Nat Chem Biol ; 16(2): 223-224, 2020 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-31896823

16.

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers.

Soula, Mariluz; Weber, Ross A; Zilka, Omkar; Alwaseem, Hanan; La, Konnor; Yen, Frederick; Molina, Henrik; Garcia-Bermudez, Javier; Pratt, Derek A; Birsoy, Kivanç.

Nat Chem Biol ; 16(12): 1351-1360, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-32778843

17.

Autoxidation vs. antioxidants - the fight for forever.

Helberg, Julian; Pratt, Derek A.

Chem Soc Rev ; 50(13): 7343-7358, 2021 Jul 05.

Artigo em Inglês | MEDLINE | ID: mdl-34037013

18.

Radical-Trapping Antioxidant Activity of Copper and Nickel Bis(Thiosemicarbazone) Complexes Underlies Their Potency as Inhibitors of Ferroptotic Cell Death.

Zilka, Omkar; Poon, Jia-Fei; Pratt, Derek A.

J Am Chem Soc ; 143(45): 19043-19057, 2021 11 17.

Artigo em Inglês | MEDLINE | ID: mdl-34730342

19.

Mechanism of Electrochemical Generation and Decomposition of Phthalimide-N-oxyl.

Yang, Cheng; Farmer, Luke A; Pratt, Derek A; Maldonado, Stephen; Stephenson, Corey R J.

J Am Chem Soc ; 143(27): 10324-10332, 2021 07 14.

Artigo em Inglês | MEDLINE | ID: mdl-34213314

20.

The chemical basis of ferroptosis.