Pesquisa | BVS Violência e Saúde

1.

Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases.

Sheetz, Joshua B; Mathea, Sebastian; Karvonen, Hanna; Malhotra, Ketan; Chatterjee, Deep; Niininen, Wilhelmiina; Perttilä, Robert; Preuss, Franziska; Suresh, Krishna; Stayrook, Steven E; Tsutsui, Yuko; Radhakrishnan, Ravi; Ungureanu, Daniela; Knapp, Stefan; Lemmon, Mark A.

Mol Cell ; 79(3): 390-405.e7, 2020 08 06.

Artigo em Inglês | MEDLINE | ID: mdl-32619402

2.

A designed ankyrin-repeat protein that targets Parkinson's disease-associated LRRK2.

Dederer, Verena; Sanz Murillo, Marta; Karasmanis, Eva P; Hatch, Kathryn S; Chatterjee, Deep; Preuss, Franziska; Abdul Azeez, Kamal R; Vu Nguyen, Landon; Galicia, Christian; Dreier, Birgit; Plückthun, Andreas; Versees, Wim; Mathea, Sebastian; Leschziner, Andres E; Reck-Peterson, Samara L; Knapp, Stefan.

J Biol Chem ; : 107469, 2024 Jun 12.

Artigo em Inglês | MEDLINE | ID: mdl-38876305

3.

Lessons from LIMK1 enzymology and their impact on inhibitor design.

Salah, Eidarus; Chatterjee, Deep; Beltrami, Alessandra; Tumber, Anthony; Preuss, Franziska; Canning, Peter; Chaikuad, Apirat; Knaus, Petra; Knapp, Stefan; Bullock, Alex N; Mathea, Sebastian.

Biochem J ; 476(21): 3197-3209, 2019 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-31652302

4.

Decay of the water reed Phragmites communis caused by the white-rot fungus Phlebia tremellosa and the influence of some environmental factors.

Dosdall, Rovena; Preuß, Franziska; Hahn, Veronika; Schlüter, Rabea; Schauer, Frieder.

Appl Microbiol Biotechnol ; 102(1): 345-354, 2018 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-29082419

5.

Enabling pseudokinases as potential drug targets.

Preuss, Franziska; Chatterjee, Deep; Dederer, Verena; Knapp, Stefan; Mathea, Sebastian.

Methods Enzymol ; 667: 663-683, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35525558

6.

Structural Aspects of LIMK Regulation and Pharmacology.

Chatterjee, Deep; Preuss, Franziska; Dederer, Verena; Knapp, Stefan; Mathea, Sebastian.

Cells ; 11(1)2022 01 02.

Artigo em Inglês | MEDLINE | ID: mdl-35011704

7.

Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.

Drewry, David H; Annor-Gyamfi, Joel K; Wells, Carrow I; Pickett, Julie E; Dederer, Verena; Preuss, Franziska; Mathea, Sebastian; Axtman, Alison D.

J Med Chem ; 65(2): 1313-1328, 2022 01 27.

Artigo em Inglês | MEDLINE | ID: mdl-34333981

8.

Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5-a]pyrimidine-Based Macrocycles.

Kurz, Christian G; Preuss, Franziska; Tjaden, Amelie; Cusack, Martin; Amrhein, Jennifer Alisa; Chatterjee, Deep; Mathea, Sebastian; Berger, Lena Marie; Berger, Benedict-Tilman; Krämer, Andreas; Weller, Michael; Weiss, Tobias; Müller, Susanne; Knapp, Stefan; Hanke, Thomas.

J Med Chem ; 65(11): 7799-7817, 2022 06 09.

Artigo em Inglês | MEDLINE | ID: mdl-35608370

9.

A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins.

Schwalm, Martin P; Berger, Lena M; Meuter, Maximilian N; Vasta, James D; Corona, Cesear R; Röhm, Sandra; Berger, Benedict-Tilman; Farges, Frederic; Beinert, Sebastian M; Preuss, Franziska; Morasch, Viktoria; Rogov, Vladimir V; Mathea, Sebastian; Saxena, Krishna; Robers, Matthew B; Müller, Susanne; Knapp, Stefan.

Front Cell Dev Biol ; 10: 886537, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35721509

10.

Nucleotide Binding, Evolutionary Insights, and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4.

Preuss, Franziska; Chatterjee, Deep; Mathea, Sebastian; Shrestha, Safal; St-Germain, Jonathan; Saha, Manipa; Kannan, Natarajan; Raught, Brian; Rottapel, Robert; Knapp, Stefan.

Structure ; 28(11): 1184-1196.e6, 2020 11 03.

Artigo em Inglês | MEDLINE | ID: mdl-32814032

11.

Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis.

Wanior, Marek; Preuss, Franziska; Ni, Xiaomin; Krämer, Andreas; Mathea, Sebastian; Göbel, Tamara; Heidenreich, David; Simonyi, Svenja; Kahnt, Astrid S; Joerger, Andreas C; Knapp, Stefan.

J Med Chem ; 63(23): 14680-14699, 2020 12 10.

Artigo em Inglês | MEDLINE | ID: mdl-33216538

12.

A Pseudo-Kinase Double Act.

Preuß, Franziska; Mathea, Sebastian; Knapp, Stefan.

Structure ; 26(4): 527-528, 2018 04 03.

Artigo em Inglês | MEDLINE | ID: mdl-29617648

13.

A Pseudo-Kinase Double Act.

Preuß, Franziska; Mathea, Sebastian; Knapp, Stefan.

Structure ; 26(11): 1564, 2018 Nov 06.

Artigo em Inglês | MEDLINE | ID: mdl-30403994

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Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases.

A designed ankyrin-repeat protein that targets Parkinson's disease-associated LRRK2.

Lessons from LIMK1 enzymology and their impact on inhibitor design.

Decay of the water reed Phragmites communis caused by the white-rot fungus Phlebia tremellosa and the influence of some environmental factors.

Enabling pseudokinases as potential drug targets.

Structural Aspects of LIMK Regulation and Pharmacology.

Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.

Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5-a]pyrimidine-Based Macrocycles.

A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins.

Nucleotide Binding, Evolutionary Insights, and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4.

Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis.

A Pseudo-Kinase Double Act.

A Pseudo-Kinase Double Act.