Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros

Base de dados
Ano de publicação
Tipo de documento
Assunto da revista
País de afiliação
Intervalo de ano de publicação
1.
Drug Chem Toxicol ; 45(1): 88-92, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31502475

RESUMO

Lead-exposure is known to disrupt the redox balance of tissues leading to oxidative stress. Due to the fact that a mucolytic drug, erdosteine, exerts also antioxidant properties, we decided to perform a pilot study on rats to evaluate its therapeutic potency in lead poisoning. Male Wistar rats were divided randomly into the following seven groups having 10 animals in each. Group I served as the control group. During 8-week period, rats in groups II-IV, except standard alimentation, received: erdosteine in a dose 350 mg/kg (collateral control group), 1200 ppm of lead acetate in drinking water and placebo, as well as the same doses of lead and erdosteine, respectively. Rats in group V-VII received 1200 ppm of lead acetate in drinking water for the initial 6-week period and then administered: placebo, erdosteine and EDTA for 2 weeks, respectively. The levels of malondialdehyde (MDA) were significantly higher in groups III and V compared to the control group. The activities of catalase (CAT) were significantly higher in groups IV, V, and VI compared to the control group. The activities of glutathione-S-transferase (GST) were significantly lower in group II and significantly higher in groups VI and VII compared to the control group, while the activities of glutathione reductase (GR) were significantly lower in group III and significantly higher in group VI. Erdosteine has an effect of protection against lead-induced oxidative stress which is not worse than that of EDTA.


Assuntos
Chumbo , Estresse Oxidativo , Animais , Antioxidantes/metabolismo , Antioxidantes/farmacologia , Catalase/metabolismo , Masculino , Malondialdeído , Músculos/metabolismo , Projetos Piloto , Ratos , Ratos Wistar , Superóxido Dismutase/metabolismo , Tioglicolatos , Tiofenos
2.
J Occup Health ; 60(5): 369-375, 2018 Sep 26.
Artigo em Inglês | MEDLINE | ID: mdl-30122729

RESUMO

OBJECTIVES: The aim of the study was to examine blood levels of selected pro-inflammatory cytokines, C reactive protein (CRP), and selected factors that influence angiogenesis in workers exposed to lead for a short period of time. METHODS: The study population consisted of 36 male workers (mean age 41 ± 14 years) exposed to lead for 40 days. RESULTS: The mean blood lead level (BLL) was 10.7 ± 7.67 µg/dl at the beginning of the study, and increased to 49.1 ± 14.1 µg/dl at the end of the study period. The levels of macrophage inflammatory protein 1-α (MIP-1α) were significantly higher after the studied exposure to lead compared to the baseline by 71%. Similarly, the values of CRP increased by 35%. Conversely, the values of soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) and fibroblast growth factor-basic (FGF-basic) decreased by 14% and 21%, respectively. After the examined period of lead exposure, analysis of correlations showed positive correlations between vascular endothelial growth factor (VEGF) levels and the levels of interleukin 1ß (IL-1ß) (R = 0.39), interleukin 6 (IL-6) (R = 0.42), and MIP-1α (R = 0.54). Positive correlations were identified between MIP-1α and FGF-basic (R = 0.38), soluble angiopoietin receptor (sTie-2) (R = 0.41), and sVEGFR-1 (R = 0.47). DISCUSSION: Short-term exposure to lead induces the inflammatory response; however, these mechanisms seem to be different from those observed in chronic lead exposure. Subacute exposure to lead may dysregulate angiogenesis via modifications in the levels of angiogenic factors.


Assuntos
Indutores da Angiogênese/sangue , Proteína C-Reativa/análise , Mediadores da Inflamação/sangue , Chumbo/sangue , Exposição Ocupacional/análise , Adulto , Biomarcadores/sangue , Quimiocina CCL3/sangue , Fatores de Crescimento de Fibroblastos/sangue , Humanos , Interleucina-1beta/sangue , Interleucina-6/sangue , Intoxicação por Chumbo/sangue , Masculino , Pessoa de Meia-Idade , Doenças Profissionais/sangue , Exposição Ocupacional/efeitos adversos , Receptor TIE-2/sangue , Fatores de Tempo , Receptor 1 de Fatores de Crescimento do Endotélio Vascular/sangue
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA