Detalhe da pesquisa
1.
Bempedoic Acid Unveils Therapeutic Potential in Non-Alcoholic Fatty Liver Disease: Suppression of the Hepatic PXR-SLC13A5/ACLY Signaling Axis.
Drug Metab Dispos
; 51(12): 1628-1641, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37684055
2.
Tanshinone IIA prevents LPS-induced inflammatory responses in mice via inactivation of succinate dehydrogenase in macrophages.
Acta Pharmacol Sin
; 42(6): 987-997, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33028985
3.
Inhibitory and inductive effects of Corydalis saxicola Bunting total alkaloids (CSBTA) on cytochrome P450s in rats.
Phytother Res
; 32(9): 1818-1827, 2018 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-29806105
4.
A simple LC-MS/MS method facilitated by salting-out assisted liquid-liquid extraction to simultaneously determine trans-resveratrol and its glucuronide and sulfate conjugates in rat plasma and its application to pharmacokinetic assay.
Biomed Chromatogr
; 31(11)2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28475242
5.
The potential drug-drug interactions of ginkgolide B mediated by renal transporters.
Phytother Res
; 29(5): 662-7, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25589475
6.
Contributions of intestine and plasma to the presystemic bioconversion of vicagrel, an acetate of clopidogrel.
Pharm Res
; 31(1): 238-51, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24037619
7.
Pharmacokinetics of thiamphenicol glycinate and its active metabolite by single and multiple intravenous infusions in healthy Chinese volunteers.
Xenobiotica
; 44(9): 819-26, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24597465
8.
In vitro cytotoxicity, pharmacokinetics and tissue distribution in rats of MXN-004, a novel conjugate of polyethylene glycol and SN38.
Xenobiotica
; 44(6): 562-9, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24308437
9.
Pharmacokinetics in Sprague-Dawley rats and Beagle dogs and in vitro metabolism of ZJM-289, a novel nitric dioxide donor.
Xenobiotica
; 44(1): 59-69, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23773000
10.
Biliary excretion of glycyrrhetinic acid: glucuronide-conjugate determination following a pharmacokinetic study of rat bile.
Phytother Res
; 28(12): 1887-9, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24849382
11.
Discovery of Highly Potent Solute Carrier 13 Member 5 (SLC13A5) Inhibitors for the Treatment of Hyperlipidemia.
J Med Chem
; 67(8): 6687-6704, 2024 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38574002
12.
Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis.
J Med Chem
; 67(6): 4603-4623, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38500250
13.
Discovery of Novel Aminobutanoic Acid-Based ASCT2 Inhibitors for the Treatment of Non-Small-Cell Lung Cancer.
J Med Chem
; 67(2): 988-1007, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38217503
14.
Intracellular spatiotemporal metabolism in connection to target engagement.
Adv Drug Deliv Rev
; 200: 115024, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37516411
15.
Opportunities and Challenges for Inhibitors Targeting Citrate Transport and Metabolism in Drug Discovery.
J Med Chem
; 66(14): 9229-9250, 2023 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37428122
16.
Hydrolytic Metabolism of Withangulatin A Mediated by Serum Albumin Instead of Common Esterases in Plasma.
Eur J Drug Metab Pharmacokinet
; 48(4): 363-376, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37344636
17.
Discovery of novel flavonoid-based CDK9 degraders for prostate cancer treatment via a PROTAC strategy.
Eur J Med Chem
; 260: 115774, 2023 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37672930
18.
Discovery of a photoactivatable dimerized STING agonist based on the benzo[b]selenophene scaffold.
Chem Sci
; 14(15): 4174-4182, 2023 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37063808
19.
Discovery of Selective and Potent Macrocyclic CDK9 Inhibitors for the Treatment of Osimertinib-Resistant Non-Small-Cell Lung Cancer.
J Med Chem
; 66(22): 15340-15361, 2023 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37870244
20.
Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment.
J Med Chem
; 66(14): 9537-9560, 2023 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37409679