RESUMO
Ketoconazole appears to be a safe drug in the treatment of chronic cavitary histoplasmosis. Primary failure and relapse have been described, requiring amphotericin B, even after long therapy with ketoconazole. Four typical cases are presented. We caution about such potential failures and stress the importance of close observation of patients begun on therapy with ketoconazole for chronic cavitary histoplasmosis.
Assuntos
Histoplasmose/tratamento farmacológico , Cetoconazol/uso terapêutico , Pneumopatias Fúngicas/tratamento farmacológico , Administração Oral , Anfotericina B/uso terapêutico , Humanos , Cetoconazol/administração & dosagem , Masculino , Pessoa de Meia-Idade , Recidiva , Fatores de TempoRESUMO
Econazole nitrate 1.0 percent cream was compared with placebo for safety and efficacy in the treatment of 126 patients with tinea versicolor. Overall results showed that 97 percent of the patients who were treated with econazole nitrate 1.0 percent cream once a day achieved excellent or partial responses, while 62 percent of those patients applying the placebo cream attained similar responses. This difference is statistically significant (p = 0.001). The study results show that econazole nitrate cream is a valuable drug for the treatment of tinea versicolor.
Assuntos
Econazol/administração & dosagem , Imidazóis/administração & dosagem , Tinha Versicolor/tratamento farmacológico , Administração Tópica , Adulto , Método Duplo-Cego , Esquema de Medicação , Econazol/uso terapêutico , Feminino , Humanos , Masculino , PlacebosRESUMO
Bacteremic Hemophilus influenzae pneumonia is an uncommon infection in the adult. It usually affects chronically ill patients, especially those with chronic obstructive lung disease, although healthy individuals can also be affected. The condition carries a significant mortality, reaching 57% in one series. We describe ten adult patients with bacteremic H influenzae pneumonia with some unique features: no deaths occurred, half of the involved patients were previously fit individuals, and a beta-lactamase producing strain was isolated in five out of ten patients. An interesting finding was the isolation of a beta-lactamase negative H influenza from the sputum of two patients whose blood cultures were positive for a beta-lactamase positive H influenza. The overall incidence of beta-lactamase production among bacteremic isolates was 50%--a finding with a great deal of impact on the treatment of this disease.