Detalhe da pesquisa
1.
Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes.
Circulation
; 139(15): 1813-1827, 2019 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30700140
2.
Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction.
Eur Heart J
; 40(40): 3318-3332, 2019 10 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31004144
3.
Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics.
J Cell Sci
; 127(Pt 17): 3666-74, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24982444
4.
Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy.
Nat Commun
; 14(1): 3714, 2023 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37349314
5.
Titin based viscosity in ventricular physiology: an integrative investigation of PEVK-actin interactions.
J Mol Cell Cardiol
; 51(3): 428-34, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21708170
6.
Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction.
Circ Res
; 105(6): 557-64, 2009 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-19679835
7.
Therapeutic inhibition of RBM20 improves diastolic function in a murine heart failure model and human engineered heart tissue.
Sci Transl Med
; 13(622): eabe8952, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34851694
8.
Deconstructing sarcomeric structure-function relations in titin-BioID knock-in mice.
Nat Commun
; 11(1): 3133, 2020 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32561764
9.
Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.
PLoS One
; 13(6): e0198492, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29889873
10.
Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.
Science
; 356(6335): 307-311, 2017 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28428423
11.
Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy.
J Mol Med (Berl)
; 94(12): 1349-1358, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27889803
12.
RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.
J Clin Invest
; 124(8): 3419-30, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24960161
13.
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing.
Nat Med
; 18(5): 766-73, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22466703
14.
Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres.
J Cell Biol
; 193(4): 785-98, 2011 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-21555460
15.
The tight junction protein CAR regulates cardiac conduction and cell-cell communication.
J Exp Med
; 205(10): 2369-79, 2008 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-18794341
16.
Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy.
Proc Natl Acad Sci U S A
; 104(9): 3444-9, 2007 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-17360664