Maternal psychological stress during pregnancy and newborn telomere length: a systematic review and meta-analysis.

INTRODUCTION: Telomeres protect the ends of chromosomes, and shorter leukocyte telomeres are associated with major group diseases. Maternal psychological stress may be related to the shortening of telomeres in infants. This systematic review and meta-analysis set out to consolidate the varying effect sizes found in studies of maternal psychological stress and telomere length (TL) in newborns and identify moderators of the relationship between stress during pregnancy and newborn TL. METHODS: Our systematic review was registered in Prospero. Six databases (PubMed, Scopus, Embase, PsycINFO, Web of Science, and CINAHL Complete) were searched for records in English from inception to February 10, 2023. Observational studies were included that measured the relationship of psychological stress of the mother during pregnancy on the TL of the newborn. The Newcastle-Ottawa quality assessment scale was used to assess the quality of the included studies. A random-effect model was selected. Statistical analysis performed by Stata software version 17. RESULTS: Eight studies were included for qualitative and four for quantitative analysis. There was an inverse statistically significant relationship between maternal stress and newborn TL; A one score increase in maternal psychological stress resulted in a 0.04 decrease in the TL of the newborn (B = -0.04, 95% CI = [-0.08, 0.00], p = 0.05). Selectivity analysis showed that the pooled effect size was sensitive to one study; After removing this study, the pooled effect size remained significant (B = -0.06, 95% CI = [-0. 10, -0.02], p < 0.001). CONCLUSION: Physiological and environmental factors can significantly affect the TL of newborns. Our results support a significant impact of maternal psychological stress on the TL of a newborn. This association demonstrates the significance of stress in influencing the telomere length, which can be a contributing factor in the infant's future. Therefore, recognizing this association is crucial for understanding and addressing potential health risks and necessitates the need for additional future studies to validate our findings.

Patterns and trends of population radiation exposure and projected the risk of exposure-induced death from gamma camera examinations in Yazd Province.

INTRODUCTION: The use of nuclear medicine examinations as imaging modalities has recently increased. This study aimed to assess the radiation dose delivered to patients from common diagnostic nuclear medicine examinations and estimate the risk of exposure-induced death (REID). In addition, the frequency of nuclear medicine procedures were evaluated from 2015-2018. MATERIALS AND METHODS: The data were collected from adult patients who had undergone cardiac, skeletal, renal, lacrimal, and thyroid imaging. For each patient, the effective dose was calculated using dose conversion factors, and REID was estimated using PCXMC. The frequency of examinations between 2015 and 2018 was obtained from the hospital information system (HIS). RESULTS: The highest estimated effective dose was attributed to the scans of myocardial stress (8.09 ± 1.28 mSv), myocardial rest (5.59 ± 1.27 mSv), and thyroid imaging (3.93 ± 0.55 mSv). In addition, cardiac stress examination had the highest REID values for solid cancers (212.5 ± 67.5) and bone scans had the highest REID values for leukemia (11.5 ± 2.5). A large increase in the number of myocardial perfusion scans was a significant contributor to an increase in collective effective dose from 23.37 man-Sv in 2015 to 49.47 man-Sv in 2018, a compound annual growth rate (CAGR) of 26%. CONCLUSION: Although the annual frequency and per capita effective dose of nuclear medicine procedures in Yazd Province increased continuously, they were comparably lower than those reported for other countries. Despite this, the cancer risks of nuclear medicine scans at the individual level are negligible (around 0.01% excess fatal cancer risk), yet the increasing tendency for these examinations could be of concern.

ESTIMATION OF DIAGNOSTIC REFERENCE LEVELS AND ACHIEVABLE DOSES FOR PEDIATRIC PATIENTS IN COMMON COMPUTED TOMOGRAPHY EXAMINATIONS: A MULTI-CENTER STUDY.

This study was conducted to determine first local diagnostic reference levels (DRLs) and achievable doses (ADs) for pediatric patients during the most common computed tomography (CT) procedures in Yazd province. The DRL was obtained based on volume CT dose index (CTDIvol) and dose length product (DLP) for four various age groups of children. Data were collected from the most commonly performed pediatric CT scans, including abdomen-pelvis, chest, brain and sinus examinations, at six high-loaded institutes. The patients' data (766 no.) in terms of CTDIvol and DLP were obtained from four age groups: ≤1-, 1-5-, 5-10- and 10-15-y-old. The 75th percentiles of CTDIvol and DLP were considered as DRL values and the 50th percentiles were described as ADs for those parameters. Consequently, the acquired DRLs were compared with other national and international published values. The DRLs in terms of CTDIvol for abdomen-pelvis, chest, brain and sinus examinations were 3, 8, 9 and 10 mGy; 4, 5, 5 and 5 mGy; 25, 28, 29 and 38 mGy; and 23, 24, 26 and 27 mGy for four different age groups of ≤1-, 1-5-, 5-10- and 10-15-y-old, respectively. The DRL values in terms of DLP were 75, 302, 321 and 342 mGy.cm; 109, 112, 135 and 170 mGy.cm, 352, 355, 360 and 481 mGy.cm; and 206, 211, 228 and 245 mGy.cm, respectively, for the mentioned age groups. In this study, the DRL and AD values in the brain examination were greater among the other studied regions. The DRL plays a critical role in the optimization of radiation doses delivered to patients and in improving their protection. This study provides the local DRLs and ADs for the most common pediatric CT scanning in Yazd province to create optimum situation for the clinical practice.