Extent of Smartphone Addiction and its Association with Physical Activity Level, Anthropometric Indices, and Quality of Sleep in Young Adults: A Cross-Sectional Study.

Background: Smartphone addiction among young adults is a growing concern that is often underestimated despite its significant health hazards. The objective of this study was to assess the extent of smartphone addiction and its association with physical activity level, anthropometric indices, and quality of sleep in young adults. Material and Methods: This cross-sectional study was conducted among 138 allied health sciences undergraduates of a tertiary care medical school in Puducherry, South India. The participants' extent of smartphone addiction, physical activity, and sleep quality were assessed using the Smartphone Addiction Scale (SAS), International Physical Activity Questionnaire, and Pittsburgh Sleep Quality Index (PSQI), respectively. Anthropometric indices (body mass index [BMI], waist-to-hip [W: H] ratio, waist-to-height [W: Ht] ratio, Conicity Index, and A Body Shape Index [ABSI]) were also measured following standardized procedures. Correlations between smartphone addiction, physical activity, anthropometric indices, and sleep quality were evaluated using Pearson's/Spearman's rank correlation coefficient. P <0.05 was considered statistically significant. Result: Over 50% of participants showed smartphone addiction and poor sleep quality. Although a significant negative correlation was observed between SAS scores and physical activity levels, significant positive correlations were noted between SAS scores and BMI and SAS and PSQI scores. Conclusion: Smartphone addiction is associated with decreased physical activity, increased BMI, and poor sleep quality in young adults.

Cardiac Dysautonomia, Decreased Baroreflex Sensitivity and Increased Myocardial Workload in Patients with Chronic Spontaneous Urticaria: A Preliminary Report.

Background: Chronic stress, a potential risk factor for cardiac autonomic dysfunction and cardiovascular (CV) risk, is known to induce the onset and exacerbation of chronic spontaneous urticaria (CSU), a psychodermatological disorder. However, data regarding CV risks due to the stress associated with CSU are very limited. Aims and Objectives: This study aimed at comparing the cardiac sympathovagal balance (SVB), inflammatory markers, perceived stress and quality of sleep in patients with CSU (test group) and normal subjects (control group). In addition, it also aimed at assessing the correlation between the SVB and other study parameters in individuals with CSU. Materials and Methods: Thirty-four patients with CSU and twenty-eight age- and gender-matched healthy controls were recruited for the study. Heart rate variability (HRV), baroreflex sensitivity (BRS) and biochemical markers of stress and inflammation (s-cortisol, interleukin (IL)-6, IL-18 and high sensitivity C-reactive protein (hs-CRP)) were assessed following standard procedures. Perceived stress and sleep quality were assessed using pre-validated questionnaires. Study parameters were compared between the test and control groups using the independent-samples Student's t-test or Mann-Whitney U-test. The correlation between SVB and other study parameters was assessed using Spearman's rank correlation coefficient test. P < 0.05 was considered statistically significant. Results: Levels of perceived stress, inflammatory markers, mean arterial pressure (MAP), myocardial workload (rate pressure product (RPP)), and HRV indices indicative of cardiac sympathetic activity were significantly high in individuals with CSU. In contrast, BRS and HRV indices indicative of parasympathetic activity and sleep quality were significantly low in these individuals. There was no significant correlation between SVB and other study parameters. Conclusions: Patients with CSU have cardiac dysautonomia characterised by increased sympathetic activity and decreased parasympathetic activity. Also, the reduced BRS and increased RPP point towards an increased risk of CV morbidity in these individuals.

Elusive Toxin in Cleistanthus collinus Causing Vasoconstriction and Myocardial Depression: Detailed NMR Analyses and Biological Studies of Cleistanthoside A.

Cleistanthus collinus leaf extracts are consumed for suicidal purposes in southern India. The boiled decoction is known to be more toxic than the fresh leaf juice. Although several compounds have been isolated and their toxicity tested, controversy remains as to which compounds are responsible for the high level of toxicity of C. collinus. We report herein that cleistanthoside A is the major toxin in the boiled aqueous extract of fresh leaves and causes death in rats in small doses. The toxicity of the boiled extract prepared in the manner described can be attributed entirely to cleistanthoside A. Cleistanthin A could also be isolated from the boiled extract, albeit in trace amounts. As hypotension not responding to vasoconstrictors is the cause of death in patients who have consumed the boiled extract, effects of cleistanthoside A on the determinants of blood pressure, namely, force of cardiac contraction and vascular resistance, were tested in isolated organ experiments. Cleistanthoside A has a direct vasoconstrictor effect; however, it inhibits ventricular contractility. Therefore, the notion that the shock in C. collinus poisoning is of vascular origin must be considered carefully, and the possibility of cardiogenic shock must be studied. We present the crystal structure of cleistanthin A and show the potency of fast NMR methods (NOAH4-BSCN-NUS) in the full spectral assignment of cleistanthoside A as a real-world sample of a natural product. We also compare the results of the NOAH4-BSCN-NUS NMR experiments with conventional NMR methods.

Hearing Impairment and High Blood Pressure among Bus Drivers in Puducherry.

INTRODUCTION: Noise Induced Hearing Loss (NIHL), a major heath concern due to constant exposure to loud noise is on the rising trend in today's world. The bus drivers are more vulnerable to the auditory and non-auditory ill effects of noise pollution. AIM: The aim of this study was to assess and compare the hearing level, blood pressure and peak expiratory flow rate of bus drivers and individuals employed in office jobs. MATERIALS AND METHODS: Fifty male bus drivers aged 30-50 years and fifty males of the same group employed in office jobs were recruited as the test and control groups respectively. The hearing level of the individuals in both the groups was assessed using the Hearing Deterioration Index (HDI). The lung function and cardiovascular status of the study participants were assessed by measuring their Peak Expiratory Flow Rate (PEFR) and Blood Pressure (BP) respectively. The mean HDI, PEFR and BP values of both the groups were compared using the unpaired t-test and the extent of correlation between HDI, service years, exposure level, systolic blood pressure (SBP) and diastolic blood pressure (DBP) was determined using Pearson correlation coefficient test. RESULTS: HDI, SBP and DBP were significantly higher among the bus drivers when compared to the controls. However, there was no significant difference in the PEFR values between the test and the control groups. There was a highly significant positive correlation between HDI and service years and exposure level. Similarly, there was a significant positive correlation between exposure level and systolic and diastolic blood pressure. CONCLUSION: Prolonged exposure to high intensity of sound results in deterioration of hearing capacity and increase in blood pressure among the bus drivers.