Pesquisa | BVS Violência e Saúde

1.

Nonclinical pharmacokinetics, pharmacodynamics and safety assessment of a FLT3L-Fc molecule for cancer immunotherapy.

Wu, Kai Connie; Adedeji, Adeyemi O; Zabka, Tanja S; Hosseini, Iraj; Kenkre, Radhika; Getz, Jennifer A; Nguyen, Tien; Decalf, Jérémie; Bainbridge, Travis W; Chilton, Jennifer A; Moussion, Christine C; Rao, Gautham K.

Toxicol Appl Pharmacol ; 483: 116837, 2024 02.

Artigo em Inglês | MEDLINE | ID: mdl-38278496

2.

Challenges and gaps in immunosafety evaluation of therapeutics: An IQ DruSafe survey.

Collinge, Mark; Neff-LaFord, Haley; Akella, Surekha; Fogal, Birgit; Fraser, Kathryn; Jabbour, Jacob; Harper, Kirsty; Maier, Curtis C; Malherbe, Laurent; Marshall, Nikki; Rao, Gautham K; Raman, Kavita; Skaggs, Hollie; Weber, Felix; Fuller, Claudette L.

Regul Toxicol Pharmacol ; 150: 105630, 2024 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-38642729

3.

Perspective on a Modified Developmental and Reproductive Toxicity Testing Strategy for Cancer Immunotherapy.

Prell, Rodney A; Halpern, Wendy G; Rao, Gautham K.

Int J Toxicol ; 35(3): 263-73, 2016 05.

Artigo em Inglês | MEDLINE | ID: mdl-26786669

4.

Repeat-dose and embryo-fetal developmental toxicity of zinpentraxin alfa.

Rao, Gautham K; Santagostino, Sara F; Wong, Lisa; Inoue, Ayumi; Arjomandi, Audrey; Yadav, Rajbharan; Halpern, Wendy G.

Reprod Toxicol ; 123: 108526, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-38141866

5.

Successful Development of Nonclinical Anti-Drug Antibody Assays to Support Zinpentraxin Alfa Reproductive Toxicology Studies.

Arjomandi, Audrey; Siradze, Ketevan; Cheu, Melissa; Davancaze, Teresa; Yadav, Rajbharan; Rao, Gautham K; Wong, Lisa; Fischer, Saloumeh K.

AAPS J ; 26(1): 16, 2024 01 24.

Artigo em Inglês | MEDLINE | ID: mdl-38267613

6.

A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule.

Hosseini, Iraj; Fleisher, Brett; Getz, Jennifer; Decalf, Jérémie; Kwong, Mandy; Ovacik, Meric; Bainbridge, Travis W; Moussion, Christine; Rao, Gautham K; Gadkar, Kapil; Kamath, Amrita V; Ramanujan, Saroja.

Pharmaceutics ; 16(5)2024 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-38794321

7.

Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease.

Ayalon, Gai; Lee, Seung-Hye; Adolfsson, Oskar; Foo-Atkins, Corinne; Atwal, Jasvinder K; Blendstrup, Mira; Booler, Helen; Bravo, Joseph; Brendza, Robert; Brunstein, Flavia; Chan, Ruby; Chandra, Priya; Couch, Jessica A; Datwani, Akash; Demeule, Barthélemy; DiCara, Danielle; Erickson, Rich; Ernst, James A; Foreman, Oded; He, Dongping; Hötzel, Isidro; Keeley, Michael; Kwok, Michael C M; Lafrance-Vanasse, Julien; Lin, Han; Lu, Yanmei; Luk, Wilman; Manser, Paul; Muhs, Andreas; Ngu, Hai; Pfeifer, Andrea; Pihlgren, Maria; Rao, Gautham K; Scearce-Levie, Kimberly; Schauer, Stephen P; Smith, William B; Solanoy, Hilda; Teng, Edmond; Wildsmith, Kristin R; Bumbaca Yadav, Daniela; Ying, Yong; Fuji, Reina N; Kerchner, Geoffrey A.

Sci Transl Med ; 13(593)2021 05 12.

Artigo em Inglês | MEDLINE | ID: mdl-33980574

8.

In Vivo Assessment of Antibody-Dependent Enhancement of Influenza B Infection.

Rao, Gautham K; Prell, Rodney A; Laing, Steven T; Burleson, Stefanie C M; Nguyen, Allen; McBride, Jacqueline M; Zhang, Crystal; Sheinson, Daniel; Halpern, Wendy G.

Toxicol Sci ; 169(2): 409-421, 2019 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-30796434

9.

T cell LFA-1-induced proinflammatory mRNA stabilization is mediated by the p38 pathway kinase MK2 in a process regulated by hnRNPs C, H1 and K.

Rao, Gautham K; Wong, Albert; Collinge, Mark; Sarhan, Joseph; Yarovinsky, Timur O; Ramgolam, Vinod S; Gaestel, Matthias; Pardi, Ruggero; Bender, Jeffrey R.

PLoS One ; 13(7): e0201103, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-30048492

10.

Induction of intracellular calcium elevation by Delta9-tetrahydrocannabinol in T cells involves TRPC1 channels.

Rao, Gautham K; Kaminski, Norbert E.

J Leukoc Biol ; 79(1): 202-13, 2006 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-16244107

11.

2-Arachidonoyl-glycerol suppresses interferon-gamma production in phorbol ester/ionomycin-activated mouse splenocytes independent of CB1 or CB2.

Kaplan, Barbara L F; Ouyang, Yanli; Rockwell, Cheryl E; Rao, Gautham K; Kaminski, Norbert E.

J Leukoc Biol ; 77(6): 966-74, 2005 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-15774549

12.

Rac, PAK, and eNOS ACTion.

Rao, Gautham K; Bender, Jeffrey R.

Circ Res ; 103(4): 328-30, 2008 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-18703782

13.

Cannabinoid receptor-mediated regulation of intracellular calcium by delta(9)-tetrahydrocannabinol in resting T cells.

Rao, Gautham K; Zhang, Wei; Kaminski, Norbert E.

J Leukoc Biol ; 75(5): 884-92, 2004 May.

Artigo em Inglês | MEDLINE | ID: mdl-14966196

14.

T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade.

Ramgolam, Vinod S; DeGregorio, Scott D; Rao, Gautham K; Collinge, Mark; Subaran, Sharmila S; Markovic-Plese, Silva; Pardi, Ruggero; Bender, Jeffrey R.

PLoS One ; 5(12): e14450, 2010 Dec 29.

Artigo em Inglês | MEDLINE | ID: mdl-21206905

15.

Cannabinoid-mediated elevation of intracellular calcium: a structure-activity relationship.

Rao, Gautham K; Kaminski, Norbert E.

J Pharmacol Exp Ther ; 317(2): 820-9, 2006 May.

Artigo em Inglês | MEDLINE | ID: mdl-16436496

16.

Cannabinol enhancement of interleukin-2 (IL-2) expression by T cells is associated with an increase in IL-2 distal nuclear factor of activated T cell activity.

Jan, Tong-Rong; Rao, Gautham K; Kaminski, Norbert E.

Mol Pharmacol ; 61(2): 446-54, 2002 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-11809870

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