Detalhe da pesquisa
1.
STOP-AD portal: Selecting the optimal pharmaceutical for preclinical drug testing in Alzheimer's disease.
Alzheimers Dement
; 19(11): 5289-5295, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37157089
2.
DISCOVERY AND VALIDATION OF GENES DRIVING DRUG-INTAKE AND RELATED BEHAVIORAL TRAITS IN MICE.
bioRxiv
; 2023 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37503148
3.
SHIP1 therapeutic target enablement: Identification and evaluation of inhibitors for the treatment of late-onset Alzheimer's disease.
Alzheimers Dement (N Y)
; 9(4): e12429, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38023622
4.
Pharmacokinetic, pharmacodynamic, and transcriptomic analysis of chronic levetiracetam treatment in 5XFAD mice: A MODEL-AD preclinical testing core study.
Alzheimers Dement (N Y)
; 8(1): e12329, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36016830
5.
3-(Pyridin-2-yl-ethynyl)benzamide metabotropic glutamate receptor 5 negative allosteric modulators: hit to lead studies.
Bioorg Med Chem Lett
; 21(1): 195-9, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21126874
6.
Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism.
Int J Neuropsychopharmacol
; 13(9): 1193-205, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20047711
7.
Integrated analysis of the molecular pathogenesis of FDXR-associated disease.
Cell Death Dis
; 11(6): 423, 2020 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32499495
8.
Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank.
Alzheimers Dement (N Y)
; 6(1): e12114, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33457489
9.
Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models.
Psychopharmacology (Berl)
; 203(1): 41-52, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18949460
10.
Postmortem transcriptional profiling reveals widespread increase in inflammation in schizophrenia: a comparison of prefrontal cortex, striatum, and hippocampus among matched tetrads of controls with subjects diagnosed with schizophrenia, bipolar or major depressive disorder.
Transl Psychiatry
; 9(1): 151, 2019 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31123247
11.
Correlating efficacy in rodent cognition models with in vivo 5-hydroxytryptamine1a receptor occupancy by a novel antagonist, (R)-N-(2-methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane carboxamide (WAY-101405).
J Pharmacol Exp Ther
; 325(1): 134-45, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18182558
12.
Increasing the levels of insulin-like growth factor-I by an IGF binding protein inhibitor produces anxiolytic and antidepressant-like effects.
Neuropsychopharmacology
; 32(11): 2360-8, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17342171
13.
Repetitive Behavioral Assessments for Compound Screening in Mouse Models of Autism Spectrum Disorders.
Methods Mol Biol
; 1438: 293-310, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27150097
14.
Future viable models of psychiatry drug discovery in pharma.
J Biomol Screen
; 18(5): 509-21, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23392517
15.
Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism.
Sci Transl Med
; 4(131): 131ra51, 2012 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22539775