[Responses of hypophyseal-adrenocortical system to stressor during repeated stress]. / Izmeneniia reaktsii gipofizarno-adrenokortikal'noi sistemy na stressor pri mnogokratnom ego povtorenii.

The corticosterone concentrations were determined in the blood of unrestrained rats exposed to 7 successive trials with 30-min. intervals. This study revealed that hormonal responses of the pituitary-adrenocortical system to stress were decreased, whereas the time of the system recovery was reduced after re-exposure to electric shock. The change seems to be dependent on the strength of the stress agent and the number of re-exposures.

[Patterns in the reacting of the hypophyseal-adrenal cortex system to multiply repeated stressors]. / Zakonomernosti reagirovaniia gipofizarno-adrenokortikal'noi sistemy na mnogokratno povtoriaiushchiesia stressory.

A degree of a blood corticosteroid increase to repeated electroshock depended on stress strength in rats. The repeated stress of small intensity (0.3 mA) resulted in an increase of reaction with compare to single stress response. The stressor of high intensity (0.5 mA) resulted in a decrease of reaction with compare to single one. There were no differences in reaction to single and repeated stressor of very high intensity (0.9 mA). There was an increase of reactivity to ACTH of incubated adrenals from rats which were exposed to repeated stress of small intensity (0.3 mA) and a decrease of reactivity of adrenal from animals which were exposed to repeated stress of high intensity (0.7 mA).

[Study of the bleeding mechanism during fibrinolysis induced by streptokinase in the rabbit (author's transl)]. / Etude du mécanisme du saignement au cours d'une fibrinolyse induite par la streptokinase chez le lapin.

Our aim in this work has been to obtain precisions on the bleeding mechanism during fibrinolysis induced by streptokinase in the rabbit. Haemostasis was studied in vivo by the method oh Honour and Russell. The injection of 40 000 u/kg of streptokinase in 10 minutes induces rapidly fibrinolysis, which lasts for approximately one hour which is not accompanied by changes either in coagulation factors, or in platelet function. In vivo : . the adhesion of platelets to the vascular lesion is normal; . platelet aggregation is normal as is the formation of intravascular thrombi; . on the other hand the intra mural platelet thrombus is unstable. The embolization of the intravascular thrombi is responsible for new hemorrhages which can be correlated with the intensity of fibrinolysis. Thus, even in the absence of fibrinogenolysis, of fibrinogen degradation products FPD, of abnormal thrombin generation and of altered platelet function, the fibrinolytic activity induced by streptokinase could alone be responsible for bleeding episodes, occuring during thrombolytic treatment by streptokinase in man.