Detalhe da pesquisa
1.
A two-million-year-long hydroclimatic context for hominin evolution in southeastern Africa.
Nature
; 560(7716): 76-79, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29988081
2.
Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies.
Bioorg Med Chem Lett
; 29(23): 126717, 2019 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31635932
3.
New Caspase-1 inhibitor by scaffold hopping into bio-inspired 3D-fragment space.
Bioorg Med Chem Lett
; 27(24): 5373-5377, 2017 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29157864
4.
The metabolic sensors FXRα, PGC-1α, and SIRT1 cooperatively regulate hepatitis B virus transcription.
FASEB J
; 28(3): 1454-63, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24297698
5.
Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries.
Bioorg Med Chem
; 23(11): 2629-35, 2015 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25600406
6.
Affinity selection mass spectrometry speeding drug discovery.
Drug Discov Today
; 28(11): 103760, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37660985
7.
Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B.
J Med Chem
; 66(15): 10694-10714, 2023 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37487467
8.
Chemical, Biochemical, Cellular, and Physiological Characterization of Leucettinib-21, a Down Syndrome and Alzheimer's Disease Drug Candidate.
J Med Chem
; 66(23): 15648-15670, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38051674
9.
Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11ß-hydroxysteroid dehydrogenase type I.
Bioorg Med Chem Lett
; 22(18): 5909-14, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22901389
10.
Therapeutic potential of compounds targeting SARS-CoV-2 helicase.
Front Chem
; 10: 1062352, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36561139
11.
Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors.
J Med Chem
; 65(2): 1396-1417, 2022 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34928152
12.
Synthesis and biological properties of macrolactam analogs of the natural product macrolide (-)-A26771B.
Bioorg Med Chem Lett
; 21(16): 4768-72, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21767951
13.
Exploring new targets and chemical space with affinity selection-mass spectrometry.
Nat Rev Chem
; 5(1): 62-71, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37118102
14.
Innovative approaches to the design and synthesis of small molecule libraries.
Bioorg Med Chem
; 23(11): 2613, 2015 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25766626
15.
Novel 2,7-Diazaspiro[4,4]nonane Derivatives to Inhibit Mouse and Human Osteoclast Activities and Prevent Bone Loss in Ovariectomized Mice without Affecting Bone Formation.
J Med Chem
; 63(22): 13680-13694, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33175535
16.
Interglacial instability of North Atlantic Deep Water ventilation.
Science
; 367(6485): 1485-1489, 2020 03 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32217728
17.
Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
Bioorg Med Chem Lett
; 19(10): 2674-8, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19395260
18.
Discovery and structure-guided drug design of inhibitors of 11beta-hydroxysteroid-dehydrogenase type I based on a spiro-carboxamide scaffold.
Bioorg Med Chem Lett
; 19(13): 3682-5, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19450980
19.
Translation of innovative chemistry into screening libraries: an exemplar partnership from the European Lead Factory.
Drug Discov Today
; 23(9): 1578-1583, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29753124
20.
Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne.
J Med Chem
; 61(9): 4030-4051, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29648825