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1.
J Eur Acad Dermatol Venereol ; 37(7): 1268-1275, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-36912427

RESUMO

Malassezia is a lipophilic yeast that is a part of the human mycobiome. Malassezia folliculitis appears when the benign colonization of the hair follicles, by the Malassezia yeasts, becomes symptomatic with pruritic papules and pustules. Although Malassezia folliculitis is common in hospital departments, diagnosing and treating it varies among dermatologists and countries. The European Academy of Dermatology and Venereology Mycology Task Force Malassezia folliculitis working group has, therefore, sought to develop these recommendations for the diagnosis and management of Malassezia folliculitis. Recommendations comprise methods for diagnosing Malassezia folliculitis, required positive findings before starting therapies and specific treatment algorithms for individuals who are immunocompetent, immunocompromised or who have compromised liver function. In conclusion, this study provides a clinical strategy for diagnosing and managing Malassezia folliculitis.


Assuntos
Dermatomicoses , Foliculite , Malassezia , Humanos , Dermatomicoses/diagnóstico , Foliculite/tratamento farmacológico
2.
J Eur Acad Dermatol Venereol ; 35(7): 1582-1586, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33768571

RESUMO

BACKGROUND: Dermatophytosis is a world-wide distributed common infection. Antifungal drug resistance in dermatophytosis used to be rare, but unfortunately the current Indian epidemic of atypical widespread recalcitrant and terbinafine-resistant dermatophytosis is spreading and has sporadically been reported in Europe. OBJECTIVES: To explore the occurrence of clinical and mycological proven antifungal drug resistance in dermatophytes in Europe. METHODS: A standardized questionnaire was distributed through the EADV Task Force of Mycology network to dermatologists in Europe. RESULTS: Representatives from 20 countries completed the questionnaires of which 17 (85 %) had observed clinical and/or mycological confirmed antifungal resistance, two countries published cases of antifungal resistance and one country had no known cases. CONCLUSIONS: This pilot study confirms that both clinical and mycological antifungal resistance exist in Europe.


Assuntos
Antifúngicos , Tinha , Antifúngicos/uso terapêutico , Europa (Continente) , Humanos , Projetos Piloto , Tinha/tratamento farmacológico , Tinha/epidemiologia , Falha de Tratamento
3.
J Eur Acad Dermatol Venereol ; 35(4): 844-883, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32976663

RESUMO

Dermatophyte infections are the most common fungal infections in humans; among them, tinea capitis (TC) - the most contagious fungal infection - is caused by anthropophilic, zoophilic and geophilic dermatophytes. The purpose of this systematic review was to determine the different aetiological variants involved in TC and the overall epidemiology of the causes of this infection in the last two decades. We searched the MEDLINE (PubMed) and Embase databases for articles published from July 2000 to August 2019 using the following search terms: 'Tinea capitis', 'Africa', 'America', 'Asia', 'Europe', 'Oceania', and the names of the countries on each continent. The flow of information through the different phases in this systematic review was depicted using a PRISMA flow diagram, which mapped the number of records identified, included and excluded, and the reasons for exclusion. Our findings indicate that the frequency of different aetiologic agents of TC in the reported studies varied globally, from 0.4-87.7% in Africa, 0.2-74.0% in North America, 0.0-91.2% in Eastern Asia, 0.0-69.0% in Eastern Europe and 2.9-86.4% in Oceania. Microsporum canis is the most frequent reported zoophilic agent worldwide, while Trichophyton violaceum and Trichophyton tonsurans are the predominant anthropophilic agents. Over time, the frequency of these latter fungal infections has increased globally, and these fungi have become the major species globally. Anthropophilic transmission - the most prevalent type of transmission - could be explained by two factors: (i) the socioeconomic status of affected countries and population groups with associated risk factors and (ii) movement of populations importing new causes of infection to areas where they had not been encountered previously. We observed that intercontinental migration and travel; globalization; environmental, climatic and ecological changes; and accelerated evolution of health technologies may influence the observed epidemiological changes and, consequently, contributed to the variations in the global status of TC.


Assuntos
Tinha do Couro Cabeludo , Arthrodermataceae , Ásia , Europa (Continente) , Europa Oriental , Humanos , Microsporum , Tinha do Couro Cabeludo/epidemiologia , Trichophyton
4.
J Eur Acad Dermatol Venereol ; 34(2): 370-376, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31515838

RESUMO

BACKGROUND AND OBJECTIVE: Body dysmorphic disorder (BDD) is a mental disorder that is difficult to diagnose, causes a lot of suffering and is more prevalent in dermatology patients than in the general population. Our objective was to screen for possible cases of BDD in patients with acne and to determine the prevalence according to DSM-IV and DSM-5 criteria, as well as to analyse the relationship between dermatological and sociodemographic variables. METHODS: A total of 245 patients diagnosed with acne in 11 dermatological centres in Spain were included in the study by members of the Aragon Psychodermatology Research Group and Spanish Research Group of Psychiatric Dermatology. We used the Body Dysmorphic Disorder Questionnaire (BDDQ) as a screening tool. RESULTS: In our sample, we obtained a prevalence for BDD of 10.6% (95% CI: 7.6-13.6%). The prevalence was the same with DSM-IV or DSM-5 criteria. Possible cases of BDD were predominantly women (P = 0.021), and 56% had non-inflammatory lesions vs. 30% of negative patients (P = 0.002). Positive patients as possible cases of BDD spent more than two hours on average a day worrying about their appearance. Most people only worried about one part of their body (86%), and in 95% of the cases, the part of their body that worried them was the face. The three most frequent compulsive behaviours in patients who screened positive for BDD were mirror checking (90.7%), camouflaging (79.1%) and using make-up (72.1%). CONCLUSIONS: As a consequence of the high prevalence of possible cases of BDD in patients with acne observed in our study, there is a need for dermatologists to screen for BDD so that they can be referred to a mental health unit to confirm the diagnosis and be offered treatment to reduce the progression of psychosocial deterioration and the development of comorbid disorders.


Assuntos
Acne Vulgar/complicações , Transtornos Dismórficos Corporais/psicologia , Acne Vulgar/psicologia , Adolescente , Adulto , Transtornos Dismórficos Corporais/complicações , Transtornos Dismórficos Corporais/epidemiologia , Feminino , Humanos , Masculino , Prevalência , Espanha/epidemiologia , Inquéritos e Questionários , Adulto Jovem
5.
J Eur Acad Dermatol Venereol ; 33(2): 421-427, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30468532

RESUMO

BACKGROUND: Superficial fungal infections are common. It is important to confirm the clinical diagnosis by mycological laboratory methods before initiating systemic antifungal treatment, especially as antifungal sensitivity and in vitro susceptibility may differ between different genera and species. For many years, the gold standard for diagnosis of superficial fungal infections has been direct fungal detection in the clinical specimen (microscopy) supplemented by culturing. Lately, newer molecular based methods for fungal identification have been developed. OBJECTIVE: This study was initiated to focus on the current usage of mycological diagnostics for superficial fungal infections by dermatologists. It was designed to investigate whether it was necessary to differentiate between initial diagnostic tests and those used at treatment follow-up in specific superficial fungal infections. METHODS: An online questionnaire was distributed among members of the EADV mycology Task Force and other dermatologists with a special interest in mycology and nail disease. RESULTS: The survey was distributed to 62 dermatologists of whom 38 (61%) completed the whole survey, 7 (11%) partially completed and 17 (27%) did not respond. Nearly, all respondents (82-100%) said that ideally they would use the result of direct microscopy (or histology) combined with a genus/species directed treatment of onychomycosis, dermatophytosis, Candida- and Malassezia-related infections. The majority of the dermatologists used a combination of clinical assessment and direct microscopy for treatment assessment and the viability of the fungus was considered more important at this visit than when initiating the treatment. Molecular based methods were not available for all responders. CONCLUSION: The available diagnostic methods are heterogeneous and their usage differs between different practices as well as between countries. The survey confirmed that dermatologists find it important to make a mycological diagnosis, particularly prior to starting oral antifungal treatment in order to confirm the diagnose and target the therapy according to genus and species.


Assuntos
Antifúngicos/administração & dosagem , Dermatomicoses/diagnóstico , Onicomicose/diagnóstico , Padrões de Prática Médica/tendências , Inquéritos e Questionários , Comitês Consultivos , Antifúngicos/farmacologia , Dermatologistas , Dermatomicoses/tratamento farmacológico , Dermatomicoses/microbiologia , Humanos , Testes de Sensibilidade Microbiana , Onicomicose/tratamento farmacológico , Onicomicose/microbiologia , Medição de Risco , Resultado do Tratamento
6.
Actas Dermosifiliogr ; 106(7): 550-4, 2015 Sep.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-26049964

RESUMO

The first biosimilar version of a biologic agent used to treat psoriasis (infliximab) entered the Spanish market on February 16 of this year, and more biosimilars can be expected to follow in the coming months and years. Logically, this new situation will have economic repercussions and alter prescribing patterns among dermatologists. In this second part of the review, we will look at several somewhat contentious issues, such as the extrapolation of indications, interchangeability, and automatic substitution. We will also review the biosimilars with indications for psoriasis currently in the clinical development pipeline and assess their potential to offer comparable efficacy and safety to the reference product while contributing to the sustainability of the public health care system.


Assuntos
Anticorpos Monoclonais/uso terapêutico , Medicamentos Biossimilares/uso terapêutico , Aprovação de Drogas/legislação & jurisprudência , Psoríase/tratamento farmacológico , Anticorpos Monoclonais/efeitos adversos , Anticorpos Monoclonais/economia , Anticorpos Monoclonais/farmacocinética , Artrite Reumatoide/tratamento farmacológico , Medicamentos Biossimilares/efeitos adversos , Medicamentos Biossimilares/economia , Medicamentos Biossimilares/farmacocinética , Ensaios Clínicos como Assunto , Substituição de Medicamentos , União Europeia , Humanos , Infliximab/efeitos adversos , Infliximab/uso terapêutico , Farmacovigilância , Espanha , Espondilite Anquilosante/tratamento farmacológico , Equivalência Terapêutica
7.
Actas Dermosifiliogr ; 106(7): 545-9, 2015 Sep.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-25987472

RESUMO

The first biosimilar version of a biologic agent used to treat psoriasis (infliximab) entered the Spanish market on February 16 of this year, and more biosimilars can be expected to follow in the coming months and years. Logically, this new situation will have economic repercussions and alter prescribing patterns among dermatologists. In this article, we review regulatory issues related to the approval of biosimilars, with a particular focus on the situation in the European Union. We will examine analytical characterization studies and special considerations for clinical trials with biosimilars, and also look at several somewhat contentious issues, such as the extrapolation of indications, interchangeability, and automatic substitution. Finally, we will review the biosimilars with indications for psoriasis currently in the clinical development pipeline and assess their potential to offer comparable efficacy and safety to the reference product while contributing to the sustainability of the public health care system.


Assuntos
Medicamentos Biossimilares/uso terapêutico , Aprovação de Drogas/legislação & jurisprudência , Psoríase/tratamento farmacológico , Medicamentos Biossimilares/efeitos adversos , Medicamentos Biossimilares/economia , Medicamentos Biossimilares/farmacocinética , Ensaios Clínicos como Assunto/economia , Ensaios Clínicos como Assunto/métodos , Composição de Medicamentos , Substituição de Medicamentos , Medicamentos Genéricos/efeitos adversos , Medicamentos Genéricos/economia , Medicamentos Genéricos/uso terapêutico , União Europeia , Humanos , Infliximab/efeitos adversos , Infliximab/uso terapêutico , Projetos de Pesquisa , Equivalência Terapêutica
8.
ScientificWorldJournal ; 2014: 340690, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25136658

RESUMO

BACKGROUND: Interleukin (IL) 33 is a recently identified pleiotropic cytokine that influences the activity of multiple cell types and orchestrates complex innate and adaptive immune responses. METHODS: We performed an extensive review of the literature published between 2005 and 2013 on IL-33 and related cytokines, their functions, and their regulation of the immune system following Candida albicans colonization. Our literature review included cross-references from retrieved articles and specific data from our own studies. RESULTS: IL-33 (IL-1F11) is a recently identified member of the IL-1 family of cytokines. Accumulating evidence suggests a pivotal role of the IL-33/ST2 axis in host immune defense against fungal pathogens, including C. albicans. IL-33 induces a Th2-type inflammatory response and activates both innate and adaptive immunity. Studies in animal models have shown that Th2 inflammatory responses have a beneficial role in immunity against gastrointestinal and systemic infections by Candida spp. CONCLUSIONS: This review summarizes the most important clinical studies and case reports describing the beneficial role of IL-33 in immunity and host defense mechanisms against pathogenic fungi. The finding that the IL-33/ST2 axis is involved in therapeutic target has implications for the prevention and treatment of inflammatory diseases, including acute or chronic candidiasis.


Assuntos
Candida albicans/patogenicidade , Candidíase/imunologia , Candidíase/microbiologia , Interleucinas/metabolismo , Animais , Candida albicans/imunologia , Candidíase/metabolismo , Humanos , Interleucina-33
9.
Actas Dermosifiliogr ; 105(1): 5-17, 2014.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-23107866

RESUMO

Histoplasmosis is a systemic infection caused by the dimorphic fungus Histoplasma capsulatum. In immunocompromised patients, primary pulmonary infection can spread to the skin and meninges. Clinical manifestations appear in patients with a CD4(+) lymphocyte count of less than 150 cells/µL. Coccidioidomycosis is a systemic mycosis caused by Coccidioides immitis and Coccidioides posadasii. It can present as diffuse pulmonary disease or as a disseminated form primarily affecting the central nervous system, the bones, and the skin. Cryptococcosis is caused by Cryptococcus neoformans (var. neoformans and var. grubii) and Cryptococcus gattii, which are members of the Cryptococcus species complex and have 5 serotypes: A, B, C, D, and AD. It is a common opportunistic infection in patients with human immunodeficiency virus (HIV)/AIDS, even those receiving antiretroviral therapy. Histopathologic examination and culture of samples from any suspicious lesions are essential for the correct diagnosis of systemic fungal infections in patients with HIV/AIDS.


Assuntos
Infecções Oportunistas Relacionadas com a AIDS/diagnóstico , Pneumopatias Fúngicas/diagnóstico , Micoses/diagnóstico , Infecções Oportunistas Relacionadas com a AIDS/microbiologia , Contagem de Linfócito CD4 , Coccidioides/isolamento & purificação , Coccidioidomicose/diagnóstico , Coccidioidomicose/epidemiologia , Coccidioidomicose/microbiologia , Coccidioidomicose/transmissão , Criptococose/diagnóstico , Criptococose/epidemiologia , Criptococose/microbiologia , Criptococose/transmissão , Cryptococcus gattii/isolamento & purificação , Cryptococcus neoformans/isolamento & purificação , Dermatomicoses/diagnóstico , Dermatomicoses/etiologia , Dermatomicoses/microbiologia , Dermatomicoses/patologia , Diagnóstico Diferencial , Fungemia/diagnóstico , Fungemia/etiologia , Fungemia/microbiologia , Histoplasma/isolamento & purificação , Histoplasmose/diagnóstico , Histoplasmose/epidemiologia , Histoplasmose/microbiologia , Histoplasmose/transmissão , Humanos , Hospedeiro Imunocomprometido , Pneumopatias Fúngicas/etiologia , Pneumopatias Fúngicas/microbiologia , Micoses/etiologia , Micoses/microbiologia , Úlcera Cutânea/etiologia , Espanha/epidemiologia
10.
Actas Dermosifiliogr ; 104(8): 694-709, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24018211

RESUMO

Biologic therapy is a well-established strategy for managing moderate and severe psoriasis. Nevertheless, the high cost of such therapy, the relatively short span of clinical experience with biologics, and the abundance of literature now available on these agents have made evidence-based and consensus-based clinical guidelines necessary. The ideal goal of psoriasis treatment is to achieve complete or nearly complete clearing of lesions and to maintain it over time. Failing that ideal, the goal would be to reduce involvement to localized lesions that can be controlled with topical therapy. Although current evidence allows us to directly or indirectly compare the efficacy or risk of primary or secondary failure of available biologics based on objective outcomes, clinical trial findings cannot be directly translated to routine practice. As a result, the prescribing physician must tailor the treatment regimen to the individual patient. This update of the clinical practice guidelines issued by the Spanish Academy of Dermatology and Venereology (AEDV) on biologic therapy for psoriasis incorporates information from the most recent publications on this topic.


Assuntos
Fatores Biológicos/uso terapêutico , Medicina Baseada em Evidências , Psoríase/tratamento farmacológico , Acitretina/uso terapêutico , Adulto , Fatores Etários , Artrite Psoriásica/tratamento farmacológico , Fatores Biológicos/efeitos adversos , Fatores Biológicos/economia , Criança , Ensaios Clínicos como Assunto , Terapia Combinada , Análise Custo-Benefício , Substituição de Medicamentos , Feminino , Humanos , Imunossupressores/uso terapêutico , Masculino , Metanálise como Assunto , Estudos Multicêntricos como Assunto , Fotoquimioterapia , Gravidez , Complicações na Gravidez/tratamento farmacológico , Índice de Gravidade de Doença , Fatores Sexuais , Espanha , Falha de Tratamento , Resultado do Tratamento
12.
Actas Dermosifiliogr ; 103(8): 679-93, 2012 Oct.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-22382200

RESUMO

While the prevalence of congenital syphilis continues to be low throughout most of the developed world, there has been a slight resurgence of the disease in several European countries, including Spain. In this context, we need to become more familiar with the signs and symptoms of this disease and consider its diagnosis in patients with only mild clinical manifestations. A definitive diagnosis may be difficult or even impossible in patients whose diagnostic tests reveal low positive titers or inconsistent results. The cornerstone of congenital syphilis control is prenatal screening and the treatment of infected mothers with penicillin, an effective and economical intervention. Based on a review of the literature supplemented by data from our own clinical experience, this article provides a detailed description of the clinical manifestations of congenital syphilis as well as the various diagnostic methods and treatments available.


Assuntos
Sífilis Congênita , Humanos , Recém-Nascido , Sífilis Congênita/diagnóstico , Sífilis Congênita/epidemiologia , Sífilis Congênita/terapia
13.
J Mycol Med ; 31(2): 101047, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33087307

RESUMO

PURPOSE: In this paper, we reported three distinct cases of tinea, including tenia ungulum, tenia pedis, and tenia cruris caused by the infection of Nannizzia nana in the immunocompetent patients who were also the residents of Guatemala. Dermatophytes were identified phenotypically and genotypically. Thereafter, DNA was extracted from the fungal isolates and a fragment of the ITS1-5.8S-ITS2 region was amplified and sequenced. The direct visual examination revealed the presence of fungal hyphae and arthroconidia. These characteristic morphological features resembled with the general features of the species, Nannizzia nana. Furthermore, nucleotide sequences that were amplified from the fungal isolates, confirmed the species identification. Thereafter, all the patients were treated with Terbinafine (250mg) through oral route for two weeks, except the patient with onychomycosis, who received the same treatment but for an extended period of three months. All the patients showed complete recovery from dermatophytosis. This study contributes to a better understanding of the epidemiology of human infections that are caused by dermatophytes, often misdiagnosed. Dermatophytes are currently less known but are now being more frequently identified due to the improvements in the diagnostic techniques.


Assuntos
Arthrodermataceae/genética , Dermatomicoses/diagnóstico , Adulto , Antifúngicos/uso terapêutico , Arthrodermataceae/patogenicidade , DNA Fúngico/genética , Dermatomicoses/tratamento farmacológico , Dermatomicoses/microbiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Técnicas de Diagnóstico Molecular , Terbinafina/uso terapêutico
14.
Open Biochem J ; 8: 21-34, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24688608

RESUMO

BACKGROUND: In recent years, research on psoriasis has focused on the identification of biomarkers for the diagnosis, pathogenesis, prognosis, or therapeutic response of the disease. These studies could provide insights into the susceptibility and natural history of psoriasis. The identification of biomarkers related to comorbidities in psoriasis, such as arthritis, cardiovascular disease, and the metabolic syndrome, is of special clinical interest. MATERIALS AND METHODS: We performed an extensive review on psoriasis biomarkers, including cytokine and growth factors, in the literature published between 1997 and 2013, including cross-references of any retrieved articles. We also included some data from our own studies. RESULTS: This review presents current knowledge of soluble biomarkers in psoriasis, including cytokines, chemokines, proangiogenic mediators, growth factors, antimicrobial proteins, neuropeptides, and oxidative stress markers. CONCLUSION: In conclusion, a number of studies have been conducted with the aim of establishing soluble biomarkers for psoriasis. Most of the biomarkers that have been studied do not meet the criteria for a clinically useful biomarker. Further work is needed to establish a role for soluble biomarkers in the diagnosis and treatment of psoriasis, with a special focus on biomarkers for psoriasis comorbidities, such as arthritis, cardiovascular disease, and the metabolic syndrome.

15.
ISRN Obstet Gynecol ; 2012: 240190, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22900198

RESUMO

Background. Infection with and persistence of high-risk human papillomavirus (HR-HPV) are the strongest risk factors for cervical cancer. In addition, other genital microorganisms may also be involved in the progression of HPV-associated lesions. Objetive. To evaluate the association of the vaginal microbiota (Candida spp., Trichomonas vaginalis, and bacterial vaginosis) with HR-HPV infection in Spanish female sex workers (FSWs). Methods. This cross-sectional study involved 208 (FSWs; age, 18-49 years) who visited a sexually transmitted infection (STI) information and prevention center (SERGAS) between January 2010 and December 2011. Face-to-face interviews were carried out. Cervical and vaginal samples were examined for human papillomavirus (HPV), Trichomonas vaginalis, Candida spp., and microorganisms related to bacterial vaginosis (BV). Results. HR-HPV was found to be significantly associated with BV in FSWs with positive results for HPV16-related types (31, 33, 35, and 52). T. vaginalis was isolated in FSWs with the following HR-HPVs: 18, 45, 66, and 68. Candida spp. were isolated only in FSWs with HPV 18-positive infection. Conclusion. We demonstrate a significant prevalence of HR-HPVs in FSWs with disturbances in the vaginal microbiota.

16.
Open AIDS J ; 5: 1-8, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-21629502

RESUMO

In Northwestern Spain (NWS), the annual incidence of AIDS diagnoses increased from 1984 (when the first case was diagnosed) until 1996. However, since 1996, this incidence has reduced considerably, including a notable 40% reduction between 1997 and 1998. The Galician Register of AIDS supplies information on the evolution of AIDS pathology in NWS. This report compiles data on patients who were diagnosed with AIDS in NWS between 1984 and 2008. From 1981, when the first case of AIDS was described, until December 31, 2008, a total of 3,766 AIDS cases were registered in NWS. Of these, 2,085 cases (55.4%) resulted in death. Examining data from individual provinces revealed that the highest number of cases was in A Coruña (1,548 cases) followed by Pontevedra (1,485 cases).For almost half of the new cases of AIDS diagnosed between 2003 and 2008 (44%), less than six months passed between the diagnosis of infection and manifestations of the disease. Thus, the number of patients that do not receive early diagnosis of HIV infection has remained high.With regard to the transmission mechanism, 64% of the cases occurring during these years resulted from needle-sharing among injected drug users (IDUs). Unprotected heterosexual and homosexual practices were responsible for 20% and 17% of the cases, respectively.

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