Pesquisa | BVS Violência e Saúde

1.

Pathogenic Aß production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1.

Kurth, Vanessa; Ogorek, Isabella; Münch, Carolina; Lopez-Rios, Javier; Ousson, Solenne; Lehmann, Sandra; Nieweg, Katja; Roebroek, Anton J M; Pietrzik, Claus U; Beher, Dirk; Weggen, Sascha.

J Biol Chem ; 299(8): 104997, 2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37394008

2.

Mutation in the distal NPxY motif of LRP1 alleviates dietary cholesterol-induced dyslipidemia and tissue inflammation.

Jaeschke, Anja; Haller, April; Cash, James G; Nam, Christopher; Igel, Emily; Roebroek, Anton J M; Hui, David Y.

J Lipid Res ; 62: 100012, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33500241

3.

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death.

Garg, Abhishek D; Krysko, Dmitri V; Verfaillie, Tom; Kaczmarek, Agnieszka; Ferreira, Gabriela B; Marysael, Thierry; Rubio, Noemi; Firczuk, Malgorzata; Mathieu, Chantal; Roebroek, Anton J M; Annaert, Wim; Golab, Jakub; de Witte, Peter; Vandenabeele, Peter; Agostinis, Patrizia.

EMBO J ; 31(5): 1062-79, 2012 Mar 07.

Artigo em Inglês | MEDLINE | ID: mdl-22252128

4.

The plasma concentration of HDL-associated apoM is influenced by LDL receptor-mediated clearance of apoB-containing particles.

Christoffersen, Christina; Benn, Marianne; Christensen, Pernille M; Gordts, Philip L S M; Roebroek, Anton J M; Frikke-Schmidt, Ruth; Tybjaerg-Hansen, Anne; Dahlbäck, Björn; Nielsen, Lars B.

J Lipid Res ; 53(10): 2198-2204, 2012 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-22826357

5.

Opposing effects of apolipoprotein m on catabolism of apolipoprotein B-containing lipoproteins and atherosclerosis.

Christoffersen, Christina; Pedersen, Tanja Xenia; Gordts, Philip L S M; Roebroek, Anton J M; Dahlbäck, Björn; Nielsen, Lars Bo.

Circ Res ; 106(10): 1624-34, 2010 May 28.

Artigo em Inglês | MEDLINE | ID: mdl-20360257

6.

Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis.

Reekmans, Sara M; Pflanzner, Thorsten; Gordts, Philip L S M; Isbert, Simone; Zimmermann, Pascale; Annaert, Wim; Weggen, Sascha; Roebroek, Anton J M; Pietrzik, Claus U.

Cell Mol Life Sci ; 67(1): 135-45, 2010 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-19856143

7.

Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate.

Louagie, Els; Taylor, Neil A; Flamez, Daisy; Roebroek, Anton J M; Bright, Nicholas A; Meulemans, Sandra; Quintens, Roel; Herrera, Pedro L; Schuit, Frans; Van de Ven, Wim J M; Creemers, John W M.

Proc Natl Acad Sci U S A ; 105(34): 12319-24, 2008 Aug 26.

Artigo em Inglês | MEDLINE | ID: mdl-18713856

8.

Inactivation of the LRP1 intracellular NPxYxxL motif in LDLR-deficient mice enhances postprandial dyslipidemia and atherosclerosis.

Gordts, Philip L S M; Reekmans, Sara; Lauwers, Annick; Van Dongen, Amber; Verbeek, Leen; Roebroek, Anton J M.

Arterioscler Thromb Vasc Biol ; 29(9): 1258-64, 2009 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-19667105

9.

Mutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development.

Roebroek, Anton J M; Reekmans, Sara; Lauwers, Annick; Feyaerts, Nathalie; Smeijers, Liesbet; Hartmann, Dieter.

Mol Cell Biol ; 26(2): 605-16, 2006 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-16382151

10.

LRP1 Has a Predominant Role in Production over Clearance of Aß in a Mouse Model of Alzheimer's Disease.

Van Gool, Bart; Storck, Steffen E; Reekmans, Sara M; Lechat, Benoit; Gordts, Philip L S M; Pradier, Laurent; Pietrzik, Claus U; Roebroek, Anton J M.

Mol Neurobiol ; 56(10): 7234-7245, 2019 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-31004319

11.

Functional expression of murine LRP1 requires correction of Lrp1 cDNA sequences.

Smeijers, Liesbet; Willems, Stefan; Lauwers, Annick; Thiry, Els; van Leuven, Fred; Roebroek, Anton J M.

Biochim Biophys Acta ; 1577(1): 155-8, 2002 Aug 19.

Artigo em Inglês | MEDLINE | ID: mdl-12151109

12.

The Matricellular Receptor LRP1 Forms an Interface for Signaling and Endocytosis in Modulation of the Extracellular Tumor Environment.

Van Gool, Bart; Dedieu, Stéphane; Emonard, Hervé; Roebroek, Anton J M.

Front Pharmacol ; 6: 271, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-26617523

13.

Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development.

Petersen, Helle Heibroch; Hilpert, Jan; Jacobsen, Christian; Lauwers, Annick; Roebroek, Anton J M; Willnow, Thomas E.

FEBS Lett ; 565(1-3): 23-7, 2004 May 07.

Artigo em Inglês | MEDLINE | ID: mdl-15135046

14.

Generation of an allelic series of knock-in mice using recombinase-mediated cassette exchange (RMCE).

Roebroek, Anton J M; Van Gool, Bart.

Methods Mol Biol ; 1194: 63-76, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-25064098

15.

Impaired LDL receptor-related protein 1 translocation correlates with improved dyslipidemia and atherosclerosis in apoE-deficient mice.

Gordts, Philip L S M; Bartelt, Alexander; Nilsson, Stefan K; Annaert, Wim; Christoffersen, Christina; Nielsen, Lars Bo; Heeren, Joerg; Roebroek, Anton J M.

PLoS One ; 7(6): e38330, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-22701627

16.

Loss of endothelial furin leads to cardiac malformation and early postnatal death.

Kim, WooJin; Essalmani, Rachid; Szumska, Dorota; Creemers, John W M; Roebroek, Anton J M; D'Orleans-Juste, Pedro; Bhattacharya, Shoumo; Seidah, Nabil G; Prat, Annik.

Mol Cell Biol ; 32(17): 3382-91, 2012 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-22733989

17.

Knock-in approaches.

Roebroek, Anton J M; Gordts, Philip L S M; Reekmans, Sara.

Methods Mol Biol ; 693: 257-75, 2011.

Artigo em Inglês | MEDLINE | ID: mdl-21080285

18.

Generation of a series of knock-in alleles using RMCE in ES cells.

Roebroek, Anton J M; Gordts, Philip L S M; Reekmans, Sara.

Methods Mol Biol ; 693: 277-81, 2011.

Artigo em Inglês | MEDLINE | ID: mdl-21080286

19.

LRP1 mediates bidirectional transcytosis of amyloid-ß across the blood-brain barrier.

Pflanzner, Thorsten; Janko, Maren C; André-Dohmen, Bettina; Reuss, Stefan; Weggen, Sascha; Roebroek, Anton J M; Kuhlmann, Christoph R W; Pietrzik, Claus U.

Neurobiol Aging ; 32(12): 2323.e1-11, 2011 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-20630619

20.

Knockin approaches.

Roebroek, Anton J M; Wu, Xiaosheng; Bram, Richard J.

Methods Mol Biol ; 209: 187-200, 2003.

Artigo em Inglês | MEDLINE | ID: mdl-12357952

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