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1.
Clin Infect Dis ; 79(3): 600-603, 2024 Sep 26.
Artigo em Inglês | MEDLINE | ID: mdl-38666412

RESUMO

In a multihospital cohort study of 3392 patients, positive urinalysis parameters had poor positive predictive value for diagnosing urinary tract infection (UTI). Combined urinalysis parameters (pyuria or nitrite) performed better than pyuria alone for ruling out UTI. However, performance of all urinalysis parameters was poor in older women.


Assuntos
Piúria , Urinálise , Infecções Urinárias , Humanos , Infecções Urinárias/diagnóstico , Infecções Urinárias/urina , Feminino , Urinálise/métodos , Urinálise/normas , Idoso , Pessoa de Meia-Idade , Masculino , Piúria/diagnóstico , Piúria/urina , Estudos de Coortes , Valor Preditivo dos Testes , Adulto , Idoso de 80 Anos ou mais , Nitritos/urina
2.
Psychol Trauma ; 8(5): 641-648, 2016 09.
Artigo em Inglês | MEDLINE | ID: mdl-26950012

RESUMO

OBJECTIVE: Adolescents living in Israel and the Palestinian authority are exposed to political violence. This review examines psychosocial risk factors for posttraumatic stress disorder (PTSD) organized within an ecological framework. METHOD: Relevant articles were identified through PubMed and PsycINFO. Studies measuring risk and/or protective factors for PTSD in the Palestinian and/or Israeli adolescent populations because of conflict exposure from 1990 to present were included. RESULTS: A total of 20 studies met inclusion criteria. Greater violence exposure, poor economic resources, living in rural compared with urban areas, poor family and peer relations, and poor coping skills were associated with PTSD symptoms. CONCLUSIONS: The ecological framework is a useful approach to understanding factors affecting adolescent PTSD. Future research should focus on socioecological levels that have received limited attention. (PsycINFO Database Record


Assuntos
Desenvolvimento do Adolescente , Conflitos Armados/psicologia , Exposição à Violência/etnologia , Transtornos de Estresse Pós-Traumáticos/etnologia , Adolescente , Humanos , Israel/etnologia , Fatores de Risco
3.
Expert Rev Hematol ; 9(5): 419-24, 2016 May.
Artigo em Inglês | MEDLINE | ID: mdl-26853281

RESUMO

Omacetaxine mepesuccinate is approved by the Food and Drug Administration in the United States for the treatment of chronic myeloid leukemia in chronic or accelerated phase resistant to two or more tyrosine kinase inhibitors. This review summarizes the mode of action, pharmacokinetics, efficacy and safety of omacetaxine mepesuccinate. Omacetaxine mepesuccinate has activity in chronic myeloid leukemia, especially in the chronic phase, regardless of the presence of ABL1 kinase domain mutations. Omacetaxine mepesuccinate has distinct but manageable adverse events profile. Omacetaxine mepesuccinate is a treatment option for a subset of patients with refractory chronic myeloid leukemia.


Assuntos
Antineoplásicos Fitogênicos/uso terapêutico , Harringtoninas/uso terapêutico , Leucemia Mielogênica Crônica BCR-ABL Positiva/tratamento farmacológico , Inibidores da Angiogênese/farmacologia , Inibidores da Angiogênese/uso terapêutico , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/farmacologia , Crise Blástica/tratamento farmacológico , Códon , Proteínas de Fusão bcr-abl/antagonistas & inibidores , Proteínas de Fusão bcr-abl/genética , Harringtoninas/química , Harringtoninas/farmacologia , Mepesuccinato de Omacetaxina , Humanos , Leucemia Mielogênica Crônica BCR-ABL Positiva/diagnóstico , Leucemia Mielogênica Crônica BCR-ABL Positiva/genética , Leucemia Mieloide de Fase Acelerada/tratamento farmacológico , Leucemia Mieloide de Fase Crônica/tratamento farmacológico , Mutação , Resultado do Tratamento
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