Pesquisa | BVS Violência e Saúde

1.

SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.

Kugel, Sita; Sebastián, Carlos; Fitamant, Julien; Ross, Kenneth N; Saha, Supriya K; Jain, Esha; Gladden, Adrianne; Arora, Kshitij S; Kato, Yasutaka; Rivera, Miguel N; Ramaswamy, Sridhar; Sadreyev, Ruslan I; Goren, Alon; Deshpande, Vikram; Bardeesy, Nabeel; Mostoslavsky, Raul.

Cell ; 165(6): 1401-1415, 2016 Jun 02.

Artigo em Inglês | MEDLINE | ID: mdl-27180906

2.

Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.

Saha, Supriya K; Parachoniak, Christine A; Ghanta, Krishna S; Fitamant, Julien; Ross, Kenneth N; Najem, Mortada S; Gurumurthy, Sushma; Akbay, Esra A; Sia, Daniela; Cornella, Helena; Miltiadous, Oriana; Walesky, Chad; Deshpande, Vikram; Zhu, Andrew X; Hezel, Aram F; Yen, Katharine E; Straley, Kimberly S; Travins, Jeremy; Popovici-Muller, Janeta; Gliser, Camelia; Ferrone, Cristina R; Apte, Udayan; Llovet, Josep M; Wong, Kwok-Kin; Ramaswamy, Sridhar; Bardeesy, Nabeel.

Nature ; 513(7516): 110-4, 2014 Sep 04.

Artigo em Inglês | MEDLINE | ID: mdl-25043045

3.

Forty-Year Trends in Cholangiocarcinoma Incidence in the U.S.: Intrahepatic Disease on the Rise.

Saha, Supriya K; Zhu, Andrew X; Fuchs, Charles S; Brooks, Gabriel A.

Oncologist ; 21(5): 594-9, 2016 05.

Artigo em Inglês | MEDLINE | ID: mdl-27000463

4.

Corrigendum: Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.

Saha, Supriya K; Parachoniak, Christine A; Ghanta, Krishna S; Fitamant, Julien; Ross, Kenneth N; Najem, Mortada S; Gurumurthy, Sushma; Akbay, Esra A; Sia, Daniela; Cornella, Helena; Miltiadous, Oriana; Walesky, Chad; Deshpande, Vikram; Zhu, Andrew X; Hezel, Aram F; Yen, Katharine E; Straley, Kimberly S; Travins, Jeremy; Popovici-Muller, Janeta; Gliser, Camelia; Ferrone, Cristina R; Apte, Udayan; Llovet, Josep M; Wong, Kwok-Kin; Ramaswamy, Sridhar; Bardeesy, Nabeel.

Nature ; 528(7580): 152, 2015 Dec 03.

Artigo em Inglês | MEDLINE | ID: mdl-26580013

5.

Prognosis and Clinicopathologic Features of Patients With Advanced Stage Isocitrate Dehydrogenase (IDH) Mutant and IDH Wild-Type Intrahepatic Cholangiocarcinoma.

Goyal, Lipika; Govindan, Aparna; Sheth, Rahul A; Nardi, Valentina; Blaszkowsky, Lawrence S; Faris, Jason E; Clark, Jeffrey W; Ryan, David P; Kwak, Eunice L; Allen, Jill N; Murphy, Janet E; Saha, Supriya K; Hong, Theodore S; Wo, Jennifer Y; Ferrone, Cristina R; Tanabe, Kenneth K; Chong, Dawn Q; Deshpande, Vikram; Borger, Darrell R; Iafrate, A John; Bardeesy, Nabeel; Zheng, Hui; Zhu, Andrew X.

Oncologist ; 20(9): 1019-27, 2015 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-26245674

6.

SRC inhibition enables formation of a growth suppressive MAGI1-PP2A complex in isocitrate dehydrogenase-mutant cholangiocarcinoma.

Luk, Iris S; Bridgwater, Caroline M; Yu, Angela; Boila, Liberalis D; Yáñez-Bartolomé, Mariana; Lampano, Aaron E; Hulahan, Taylor S; Boukhali, Myriam; Kathiresan, Meena; Macarulla, Teresa; Kenerson, Heidi L; Yamamoto, Naomi; Sokolov, David; Engstrom, Ian A; Sullivan, Lucas B; Lampe, Paul D; Cooper, Jonathan A; Yeung, Raymond S; Tian, Tian V; Haas, Wilhelm; Saha, Supriya K; Kugel, Sita.

Sci Transl Med ; 16(747): eadj7685, 2024 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-38748774

7.

SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers.

Shi, Lei; Shen, William; Davis, Mindy I; Kong, Ke; Vu, Phuong; Saha, Supriya K; Adil, Ramzi; Kreuzer, Johannes; Egan, Regina; Lee, Tobie D; Greninger, Patricia; Shrimp, Jonathan H; Zhao, Wei; Wei, Ting-Yu; Zhou, Mi; Eccleston, Jason; Sussman, Jonathan; Manocha, Ujjawal; Weerasekara, Vajira; Kondo, Hiroshi; Vijay, Vindhya; Wu, Meng-Ju; Kearney, Sara E; Ho, Jeffrey; McClanaghan, Joseph; Murchie, Ellen; Crowther, Giovanna S; Patnaik, Samarjit; Boxer, Matthew B; Shen, Min; Ting, David T; Kim, William Y; Stanger, Ben Z; Deshpande, Vikram; Ferrone, Cristina R; Benes, Cyril H; Haas, Wilhelm; Hall, Matthew D; Bardeesy, Nabeel.

Nat Cancer ; 4(3): 365-381, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36914816

8.

Rescue of TRAF3-null mice by p100 NF-kappa B deficiency.

He, Jeannie Q; Zarnegar, Brian; Oganesyan, Gagik; Saha, Supriya K; Yamazaki, Soh; Doyle, Sean E; Dempsey, Paul W; Cheng, Genhong.

J Exp Med ; 203(11): 2413-8, 2006 Oct 30.

Artigo em Inglês | MEDLINE | ID: mdl-17015635

9.

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response.

Oganesyan, Gagik; Saha, Supriya K; Guo, Beichu; He, Jeannie Q; Shahangian, Arash; Zarnegar, Brian; Perry, Andrea; Cheng, Genhong.

Nature ; 439(7073): 208-11, 2006 Jan 12.

Artigo em Inglês | MEDLINE | ID: mdl-16306936

10.

Type I interferon production enhances susceptibility to Listeria monocytogenes infection.

O'Connell, Ryan M; Saha, Supriya K; Vaidya, Sagar A; Bruhn, Kevin W; Miranda, Gustavo A; Zarnegar, Brian; Perry, Andrea K; Nguyen, Bidong O; Lane, Timothy F; Taniguchi, Tadatsugu; Miller, Jeff F; Cheng, Genhong.

J Exp Med ; 200(4): 437-45, 2004 Aug 16.

Artigo em Inglês | MEDLINE | ID: mdl-15302901

11.

TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholangiocarcinoma.

Goyal, Lipika; Shi, Lei; Liu, Leah Y; Fece de la Cruz, Ferran; Lennerz, Jochen K; Raghavan, Srivatsan; Leschiner, Ignaty; Elagina, Liudmila; Siravegna, Giulia; Ng, Raymond W S; Vu, Phuong; Patra, Krushna C; Saha, Supriya K; Uppot, Raul N; Arellano, Ron; Reyes, Stephanie; Sagara, Takeshi; Otsuki, Sachie; Nadres, Brandon; Shahzade, Heather A; Dey-Guha, Ipsita; Fetter, Isobel J; Baiev, Islam; Van Seventer, Emily E; Murphy, Janet E; Ferrone, Cristina R; Tanabe, Kenneth K; Deshpande, Vikram; Harding, James J; Yaeger, Rona; Kelley, Robin K; Bardelli, Alberto; Iafrate, A John; Hahn, William C; Benes, Cyril H; Ting, David T; Hirai, Hiroshi; Getz, Gad; Juric, Dejan; Zhu, Andrew X; Corcoran, Ryan B; Bardeesy, Nabeel.

Cancer Discov ; 9(8): 1064-1079, 2019 08.

Artigo em Inglês | MEDLINE | ID: mdl-31109923

12.

TRAF3 and its biological function.

He, Jeannie Q; Oganesyan, Gagik; Saha, Supriya K; Zarnegar, Brian; Cheng, Genhong.

Adv Exp Med Biol ; 597: 48-59, 2007.

Artigo em Inglês | MEDLINE | ID: mdl-17633016

13.

Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma.

Goyal, Lipika; Saha, Supriya K; Liu, Leah Y; Siravegna, Giulia; Leshchiner, Ignaty; Ahronian, Leanne G; Lennerz, Jochen K; Vu, Phuong; Deshpande, Vikram; Kambadakone, Avinash; Mussolin, Benedetta; Reyes, Stephanie; Henderson, Laura; Sun, Jiaoyuan Elisabeth; Van Seventer, Emily E; Gurski, Joseph M; Baltschukat, Sabrina; Schacher-Engstler, Barbara; Barys, Louise; Stamm, Christelle; Furet, Pascal; Ryan, David P; Stone, James R; Iafrate, A John; Getz, Gad; Porta, Diana Graus; Tiedt, Ralph; Bardelli, Alberto; Juric, Dejan; Corcoran, Ryan B; Bardeesy, Nabeel; Zhu, Andrew X.

Cancer Discov ; 7(3): 252-263, 2017 03.

Artigo em Inglês | MEDLINE | ID: mdl-28034880

14.

The interferon response to bacterial and viral infections.

Pietras, Eric M; Saha, Supriya K; Cheng, Genhong.

J Endotoxin Res ; 12(4): 246-50, 2006.

Artigo em Inglês | MEDLINE | ID: mdl-16953977

15.

Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma.

Saha, Supriya K; Gordan, John D; Kleinstiver, Benjamin P; Vu, Phuong; Najem, Mortada S; Yeo, Jia-Chi; Shi, Lei; Kato, Yasutaka; Levin, Rebecca S; Webber, James T; Damon, Leah J; Egan, Regina K; Greninger, Patricia; McDermott, Ultan; Garnett, Mathew J; Jenkins, Roger L; Rieger-Christ, Kimberly M; Sullivan, Travis B; Hezel, Aram F; Liss, Andrew S; Mizukami, Yusuke; Goyal, Lipika; Ferrone, Cristina R; Zhu, Andrew X; Joung, J Keith; Shokat, Kevan M; Benes, Cyril H; Bardeesy, Nabeel.

Cancer Discov ; 6(7): 727-39, 2016 07.

Artigo em Inglês | MEDLINE | ID: mdl-27231123

16.

IDH mutations in liver cell plasticity and biliary cancer.

Saha, Supriya K; Parachoniak, Christine A; Bardeesy, Nabeel.

Cell Cycle ; 13(20): 3176-82, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-25485496

17.

Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma.

Borger, Darrell R; Goyal, Lipika; Yau, Thomas; Poon, Ronnie T; Ancukiewicz, Marek; Deshpande, Vikram; Christiani, David C; Liebman, Hannah M; Yang, Hua; Kim, Hyeryun; Yen, Katharine; Faris, Jason E; Iafrate, A John; Kwak, Eunice L; Clark, Jeffrey W; Allen, Jill N; Blaszkowsky, Lawrence S; Murphy, Janet E; Saha, Supriya K; Hong, Theodore S; Wo, Jennifer Y; Ferrone, Cristina R; Tanabe, Kenneth K; Bardeesy, Nabeel; Straley, Kimberly S; Agresta, Sam; Schenkein, David P; Ellisen, Leif W; Ryan, David P; Zhu, Andrew X.

Clin Cancer Res ; 20(7): 1884-90, 2014 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-24478380

18.

IRF3-dependent type I interferon response in B cells regulates CpG-mediated antibody production.

Oganesyan, Gagik; Saha, Supriya K; Pietras, Eric M; Guo, Beichu; Miyahira, Andrea K; Zarnegar, Brian; Cheng, Genhong.

J Biol Chem ; 283(2): 802-8, 2008 Jan 11.

Artigo em Inglês | MEDLINE | ID: mdl-17925397

19.

Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway.

He, Jeannie Q; Saha, Supriya K; Kang, Jason R; Zarnegar, Brian; Cheng, Genhong.

J Biol Chem ; 282(6): 3688-94, 2007 Feb 09.

Artigo em Inglês | MEDLINE | ID: mdl-17158868

20.

TRAF3: a new regulator of type I interferons.

Saha, Supriya K; Cheng, Genhong.

Cell Cycle ; 5(8): 804-7, 2006 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-16582590

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