Pesquisa | BVS Violência e Saúde

1.

De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity.

Mout, Rubul; Bretherton, Ross C; Decarreau, Justin; Lee, Sangmin; Gregorio, Nicole; Edman, Natasha I; Ahlrichs, Maggie; Hsia, Yang; Sahtoe, Danny D; Ueda, George; Sharma, Alee; Schulman, Rebecca; DeForest, Cole A; Baker, David.

Proc Natl Acad Sci U S A ; 121(6): e2309457121, 2024 Feb 06.

Artigo em Inglês | MEDLINE | ID: mdl-38289949

2.

Design of amyloidogenic peptide traps.

Sahtoe, Danny D; Andrzejewska, Ewa A; Han, Hannah L; Rennella, Enrico; Schneider, Matthias M; Meisl, Georg; Ahlrichs, Maggie; Decarreau, Justin; Nguyen, Hannah; Kang, Alex; Levine, Paul; Lamb, Mila; Li, Xinting; Bera, Asim K; Kay, Lewis E; Knowles, Tuomas P J; Baker, David.

Nat Chem Biol ; 2024 Mar 19.

Artigo em Inglês | MEDLINE | ID: mdl-38503834

3.

Exploiting conformational dynamics to modulate the function of designed proteins.

Rennella, Enrico; Sahtoe, Danny D; Baker, David; Kay, Lewis E.

Proc Natl Acad Sci U S A ; 120(18): e2303149120, 2023 05 02.

Artigo em Inglês | MEDLINE | ID: mdl-37094170

4.

Generation of ordered protein assemblies using rigid three-body fusion.

Vulovic, Ivan; Yao, Qing; Park, Young-Jun; Courbet, Alexis; Norris, Andrew; Busch, Florian; Sahasrabuddhe, Aniruddha; Merten, Hannes; Sahtoe, Danny D; Ueda, George; Fallas, Jorge A; Weaver, Sara J; Hsia, Yang; Langan, Robert A; Plückthun, Andreas; Wysocki, Vicki H; Veesler, David; Jensen, Grant J; Baker, David.

Proc Natl Acad Sci U S A ; 118(23)2021 06 08.

Artigo em Inglês | MEDLINE | ID: mdl-34074752

5.

Transferrin receptor targeting by de novo sheet extension.

Sahtoe, Danny D; Coscia, Adrian; Mustafaoglu, Nur; Miller, Lauren M; Olal, Daniel; Vulovic, Ivan; Yu, Ta-Yi; Goreshnik, Inna; Lin, Yu-Ru; Clark, Lars; Busch, Florian; Stewart, Lance; Wysocki, Vicki H; Ingber, Donald E; Abraham, Jonathan; Baker, David.

Proc Natl Acad Sci U S A ; 118(17)2021 04 27.

Artigo em Inglês | MEDLINE | ID: mdl-33879614

6.

Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G.

Sahtoe, Danny D; van Dijk, Willem J; El Oualid, Farid; Ekkebus, Reggy; Ovaa, Huib; Sixma, Titia K.

Mol Cell ; 57(5): 887-900, 2015 Mar 05.

Artigo em Inglês | MEDLINE | ID: mdl-25702870

7.

Layers of DUB regulation.

Sahtoe, Danny D; Sixma, Titia K.

Trends Biochem Sci ; 40(8): 456-67, 2015 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-26073511

8.

De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity.

Mout, Rubul; Bretherton, Ross C; Decarreau, Justin; Lee, Sangmin; Edman, Natasha I; Ahlrichs, Maggie; Hsia, Yang; Sahtoe, Danny D; Ueda, George; Gregorio, Nicole; Sharma, Alee; Schulman, Rebecca; DeForest, Cole A; Baker, David.

bioRxiv ; 2023 Jun 03.

Artigo em Inglês | MEDLINE | ID: mdl-37398067

9.

Reconfigurable asymmetric protein assemblies through implicit negative design.

Sahtoe, Danny D; Praetorius, Florian; Courbet, Alexis; Hsia, Yang; Wicky, Basile I M; Edman, Natasha I; Miller, Lauren M; Timmermans, Bart J R; Decarreau, Justin; Morris, Hana M; Kang, Alex; Bera, Asim K; Baker, David.

Science ; 375(6578): eabj7662, 2022 01 21.

Artigo em Inglês | MEDLINE | ID: mdl-35050655

10.

Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases.

Luna-Vargas, Mark P A; Christodoulou, Evangelos; Alfieri, Andrea; van Dijk, Willem J; Stadnik, Magda; Hibbert, Richard G; Sahtoe, Danny D; Clerici, Marcello; Marco, Valeria De; Littler, Dene; Celie, Patrick H N; Sixma, Titia K; Perrakis, Anastassis.

J Struct Biol ; 175(2): 113-9, 2011 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-21453775

11.

BAP1/ASXL1 recruitment and activation for H2A deubiquitination.

Sahtoe, Danny D; van Dijk, Willem J; Ekkebus, Reggy; Ovaa, Huib; Sixma, Titia K.

Nat Commun ; 7: 10292, 2016 Jan 07.

Artigo em Inglês | MEDLINE | ID: mdl-26739236

12.

The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A.

Mattiroli, Francesca; Uckelmann, Michael; Sahtoe, Danny D; van Dijk, Willem J; Sixma, Titia K.

Nat Commun ; 5: 3291, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-24518117

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De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity.

Design of amyloidogenic peptide traps.

Exploiting conformational dynamics to modulate the function of designed proteins.

Generation of ordered protein assemblies using rigid three-body fusion.

Transferrin receptor targeting by de novo sheet extension.

Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G.

Layers of DUB regulation.

De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity.

Reconfigurable asymmetric protein assemblies through implicit negative design.

Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases.

BAP1/ASXL1 recruitment and activation for H2A deubiquitination.

The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A.