1.
Bioorg Med Chem Lett
; 18(20): 5545-9, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18819799
RESUMO
A series of novel potent benzimidazole based inhibitors of interleukin-2 T-cell kinase (Itk) were prepared. In this report, we discuss the structure-activity relationship (SAR), selectivity, and cell-based activity for the series. We also discuss the SAR associated with an X-ray structure of one of the small-molecule inhibitors bound to ITK.