RESUMO
Cytoplasmic accumulation of hemosiderin was observed within astrocytes and neurons as well as in other phagocytes associated with old encephalomalacia. The first patient was 3 years old when she died with malnutrition and superimposed infection. A cortical infarct had been caused by an old thrombus in a small artery. The second case was a 9-year-old girl who had old encephalomalacia in the pineal region after extirpation of a pineoloma. The third patient was a 22-year-old man who had a cortical infarct from an embolus associated with chronic rheumatic endocarditis. Granules of hemosiderin had accumulated within the perikaryon of many astrocytes and other phagocytes in all cases, and in a few neurons in the second instance. Review of the literature reveals that cytoplasmic accumulation of particulate matter has been described infrequently with regard to neuroepithelial derivatives. Our findings indicate that astrocytes and neurons as well as derivations of mesenchyme may act as phagocytes of old blood.
Assuntos
Astrócitos/ultraestrutura , Encefalomalacia/patologia , Fagocitose , Adulto , Encéfalo/patologia , Criança , Pré-Escolar , Feminino , Hemossiderina/metabolismo , Humanos , Masculino , Neurônios/ultraestruturaAssuntos
Aneurisma/patologia , Doença das Coronárias/patologia , Aneurisma Cardíaco/patologia , Adulto , Autopsia , Humanos , MasculinoAssuntos
Fibrossarcoma/patologia , Neoplasias de Cabeça e Pescoço/patologia , Recidiva Local de Neoplasia/patologia , Neoplasias do Sistema Nervoso Periférico/patologia , Adolescente , Criança , Terapia Combinada , Feminino , Fibrossarcoma/terapia , Neoplasias de Cabeça e Pescoço/terapia , Humanos , Neoplasias do Sistema Nervoso Periférico/terapiaRESUMO
A case is reported of a neoplasm of mixed mesenchymal and neuroepithelial origin consisting of plasmacytoma, lymphoma, ganglioneuroma, and astrocytoma in the same mass. The tumour arose in the hypothalamus of a 43 year old diabetic woman who also had alpha cell hyperplasia and beta cell hypoplasia of the islets of Langerhans. It is suggested that both hypothalamic and pancreatic lesions produced diabetes mellitus in this patient.
Assuntos
Neoplasias Encefálicas/complicações , Diabetes Mellitus/etiologia , Hipotálamo , Pancreatopatias/complicações , Adulto , Astrocitoma/complicações , Neoplasias Encefálicas/patologia , Feminino , Ganglioneuroma/complicações , Humanos , Hipotálamo/patologia , Ilhotas Pancreáticas/anormalidades , Linfoma/complicações , Pâncreas/patologia , Plasmocitoma/complicaçõesRESUMO
Six cases of chronic calcific pancreatitis in Thailand occurring in patients aged 13 to 22 years are reported. Protein malnutrition was a possible aetiologic factor. Abdominal pain was mild to moderate and intermittent and not a presenting feature. Severe diabetes mellitus was present at all. Extensive pancreatic calcification was seeen on abdominal X-ray.