RESUMO
AIM: Severe asthma is a complex, heterogeneous condition that can be difficult to control despite currently available treatments. Multidisciplinary severe asthma units (SAU) improve control in these patients and are cost-effective in our setting; however, their implementation and development can represent an organizational challenge. The aim of this study was to validate a set of quality care indicators in severe asthma for SAU in Spain. METHODS: The Carabela initiative, sponsored by SEPAR, SEAIC, SECA and SEDISA and implemented by leading specialists, analyzed the care processes followed in 6 pilot centers in Spain to describe the ideal care pathway for severe asthma. This analysis, together with clinical guidelines and SEPAR and SEAIC accreditation criteria for asthma units, were used to draw up a set of 11 quality of care indicators, which were validated by a panel of 60 experts (pulmonologists, allergologists, and health-policy decision-makers) using a modified Delphi method. RESULTS: All 11 indicators achieved a high level of consensus after just one Delphi round. CONCLUSIONS: Experts in severe asthma agree on a series of minimum requirements for the future optimization, standardization, and excellence of current SAUs in Spain. This proposal is well grounded on evidence and professional experience, but the validity of these consensus indicators must be evaluated in clinical practice.
Assuntos
Asma , Indicadores de Qualidade em Assistência à Saúde , Humanos , Consenso , Técnica Delphi , Asma/terapia , EspanhaRESUMO
Colorectal cancer (CRC) is a leading cause of cancer death in the United States. Standard treatment for advanced-stage CRC for decades has included 5-fluorouracil-based chemotherapy. More recently, targeted therapies for metastatic CRC are being used based on the individual cancer's molecular profile. In the past few years, several different molecular subtype schemes for human CRC have been developed. The molecular subtypes can be distinguished by gene expression signatures and have the potential to be used to guide treatment decisions. However, many subtyping classification methods were developed using mRNA expression levels of hundreds to thousands of genes, making them impractical for clinical use. In this study, we assessed whether an immunohistochemical approach could be used for molecular subtyping of CRCs. We validated two previously published, independent sets of immunohistochemistry classifiers and modified the published methods to improve the accuracy of the scoring methods. In addition, we evaluated whether protein and genetic signatures identified originally in the mouse were linked to clinical outcomes of patients with CRC. We found that low DDAH1 or low GAL3ST2 protein levels in human CRCs correlate with poor patient outcomes. The results of this study have the potential to impact methods for determining the prognosis and therapy selection for patients with CRC.
Assuntos
Adenocarcinoma/química , Amidoidrolases/análise , Biomarcadores Tumorais/análise , Neoplasias Colorretais/química , Imuno-Histoquímica , Sulfotransferases/análise , Adenocarcinoma/classificação , Adenocarcinoma/genética , Adenocarcinoma/patologia , Idoso , Amidoidrolases/genética , Animais , Biomarcadores Tumorais/genética , Neoplasias Colorretais/classificação , Neoplasias Colorretais/genética , Neoplasias Colorretais/patologia , Feminino , Genes APC , Humanos , Masculino , Camundongos Transgênicos , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Prognóstico , Reprodutibilidade dos Testes , Sulfotransferases/genética , Análise Serial de TecidosRESUMO
PURPOSE: Estimating cancer risk associated with interplanetary space travel is complicated. Human exposure data to high atomic number, high-energy (HZE) radiation is lacking, so data from low linear energy transfer (low-LET) γ-ray radiation is used in risk models, with the assumption that HZE and γ-ray radiation have comparable biological effects. This assumption has been challenged by reports indicating that HZE radiation might produce more aggressive tumors. The goal of this research is to test whether high-LET HZE radiation induced tumors are more aggressive. MATERIALS AND METHODS: Murine models of mammary and liver cancer were used to compare the impact of exposure to 0.2Gy of 300MeV/n silicon ions, 3 Gy of γ-rays or no radiation. Numerous measures of tumor aggressiveness were assessed. RESULTS: For the mammary cancer models, there was no significant change in the tumor latency or metastasis in silicon-irradiated mice compared to controls. For the liver cancer models, we observed an increase in tumor incidence but not tumor aggressiveness in irradiated mice. CONCLUSION: Tumors in the HZE-irradiated mice were not more aggressive than those arising from exposure to low-LET γ-rays or spontaneously. Thus, enhanced aggressiveness does not appear to be a uniform characteristic of all tumors in HZE-irradiated animals.
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Carcinoma Hepatocelular/patologia , Neoplasias Hepáticas/patologia , Neoplasias Mamárias Experimentais/patologia , Animais , Relação Dose-Resposta à Radiação , Feminino , Humanos , Transferência Linear de Energia , CamundongosRESUMO
The Clinic Institute of Nefro and Urology (ICNU) was formed in Clinic Hospital of Barcelona in 1999. It grouped together services of Nephrology, Urology and Renal Transplant. At the same time, in order to ensure Quality in this process of change, we designed a specific quality program. In this program, we defined objectives to improve the quality of these services in one year and we defined different quality indicators in order to maintain and monitor health quality. The indicators referred to technical quality and perceived quality and we periodically evaluated their evolution. The results of the last five years indicate that the majority of the indicators have improved, except those concerning infections surgery and the response to complaints. This has helped the consolidation and recognition of the work of this innovatory project in the health management of the nephrologic and urinary systems that locate the patient in the center of the organization and recognize the health professionals as the true managers of this model.
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Academias e Institutos/organização & administração , Gerenciamento Clínico , Hospitais Universitários/organização & administração , Garantia da Qualidade dos Cuidados de Saúde/organização & administração , Doenças Urológicas/terapia , Humanos , Admissão do Paciente/estatística & dados numéricos , Alta do Paciente/estatística & dados numéricos , Educação de Pacientes como Assunto/organização & administração , Satisfação do Paciente , Assistência Centrada no Paciente/organização & administração , Política , Indicadores de Qualidade em Assistência à Saúde , Encaminhamento e Consulta/estatística & dados numéricos , Espanha , Procedimentos Cirúrgicos Urológicos/normas , Procedimentos Cirúrgicos Urológicos/estatística & dados numéricosRESUMO
INTRODUCTION: Cigarette smoking is associated with many adverse health effects and is an important public health concern. Increased understanding of smokers' behavior is central to developing effective interventions. Cigarette scavenging, a behavior that involves smoking shared or previously used cigarettes has thus far only been shown to be prevalent among homeless or incarcerated populations. The current study examines whether cigarette scavenging is prevalent in a more general population of adult smokers enrolling in a smoking cessation clinical trial, and whether engagement in this behavior is associated with demographic or smoking-related psychosocial factors. METHODS: Baseline data was obtained from adult smokers (N=227) enrolling in a randomized clinical trial for smoking cessation. Cigarette scavenging was assessed using three items: a) sharing a cigarette with a stranger; b) smoking a "found" cigarette and c) smoking a previously used cigarette "butt". Participants who endorsed engaging in at least one of these three behaviors were categorized as a scavenger. RESULTS: Approximately 32% of participants endorsed at least one cigarette scavenging behavior. A multiple logistic regression analysis found that scavengers were more likely to be: men (p<0.001), of younger age at smoking onset (p=0.012), unemployed (p=0.003), more likely to have used marijuana in the past 30days (p=0.005), single or living alone (p=0.003), and to have experienced higher withdrawal symptoms during previous quit attempts (p=0.044) as compared to non-scavengers. CONCLUSIONS: Scavenging is common among adult smokers. Interventions that address cigarette scavenging behaviors may better meet the needs of this unique smoking subgroup.
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Fumar Cigarros/psicologia , Abandono do Hábito de Fumar/psicologia , Produtos do Tabaco , Tabagismo/psicologia , Adolescente , Adulto , Idoso , Comportamento Cooperativo , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto JovemAssuntos
Betacoronavirus/isolamento & purificação , Infecções por Coronavirus/epidemiologia , Pandemias , Segurança do Paciente , Assistência Perioperatória , Pneumonia Viral/epidemiologia , COVID-19 , Infecções por Coronavirus/virologia , Educação Continuada , Humanos , Pneumonia Viral/virologia , SARS-CoV-2 , IncertezaRESUMO
OBJECTIVES: To determine whether the objectives entrusted to the Scientific Committee (SC) of the 28th National Conference have been met, and to determine whether the results differed from those of previous conferences. METHODS: A chronological description of the work of the SC and a comparison with the results of the previous two Conferences of the Spanish Society for Quality in health care (SSQHC). RESULTS: A total of 869 papers were submitted, of which 32.6% corresponded to the area of patient safety. Galicia was the community that presented more communications (28%), followed by Catalonia (12.9%) and Murcia (10.9%). CONCLUSIONS: The methodology used by the SC helped in the compliance with the deadlines in the SSQHC Conference manual and contributed to achieve its objectives. Abstract presentations were classified accordingly to their quality. The Conference has been consolidated as a multidisciplinary meeting with participation by doctors, nurses, managers and open to the Latin-American community.
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Objetivos , Garantia da Qualidade dos Cuidados de Saúde , Qualidade da Assistência à Saúde , Sociedades Médicas , Congressos como Assunto , EspanhaRESUMO
SERPINB3 is a serine protease inhibitor with pleiotropic functions. It is involved in several physiological and pathological processes, where it appears to exert antiapoptotic effects. Little is known about its expression on immune system cells, the major players in mechanisms of viral defense and autoimmune disorders. The aim of this study was to characterize the expression of SERPINB3 on the surface of peripheral blood mononuclear cell subsets in both normal subjects and in patients with chronic viral infections and autoimmune diseases. Sixty-two patients were analyzed by flow cytometric analysis, including 45 with hepatitis C virus (HCV)-related chronic liver disease and 17 with systemic lupus erythematosus (SLE). SERPINB3 was expressed on B lymphocytes in 79% of the controls, in 32% of the HCV-infected patients and in none of the SLE patients. Surface localization of SERPINB3 was confirmed by confocal microscopy. SERPINB3 positivity was associated with CD27 reactivity (r = 0.98), but not to other activation molecules (CD69, CD71, CD86 and CXCR3). SERPINB3 is physiologically expressed on the surface of CD27(+) B lymphocytes, but its expression is reduced in HCV viral infection and not detectable in SLE patients. These results may suggest a role for SERPINB3 in B-cell defects typically found in viral infections and autoimmune disorders.
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Antígenos de Neoplasias/metabolismo , Linfócitos B/enzimologia , Hepatite C Crônica/metabolismo , Lúpus Eritematoso Sistêmico/metabolismo , Serpinas/metabolismo , Adulto , Idoso , Antígenos de Neoplasias/genética , Sequência de Bases , Estudos de Casos e Controles , Primers do DNA , Feminino , Citometria de Fluxo , Humanos , Masculino , Microscopia Confocal , Pessoa de Meia-Idade , RNA Mensageiro/genética , Reação em Cadeia da Polimerase em Tempo Real , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Serpinas/genéticaRESUMO
AIMS: Assessment of effectiveness of a plan entitled «Smoke-free hospitals¼, specifically the reduction in the number of smoking staff and an increase in smoke-free areas. METHOD: Interventional, non-controlled, populational study. A baseline study was conducted in 2004 to find out the situation as regards the prevalence of smokers in our hospital and the support of health workers for the smoke-free hospital plan. We used the questionnaire validated for the European smoke free hospital network in a sample of 483 workers randomly selected and stratified by gender, age and establishment. In 2007 we repeated the study with the same methodology to ascertain the progress of the project, in this case a sample of 425 workers was collected. RESULTS: The number of smoking workers had decreased from 35.2% to 27.4 (P<.05). This reduction was seen in virtually all sectors, but was less so in nursing staff. In 2007 we had achieved that people only smoke in smoking areas (P<.0001). The plan was supported by smokers and non-smokers. CONCLUSIONS: The «Smoke-free hospital¼ plan has achieved the objectives proposed. The actions carried out helped to enforce the law and respect that hospital areas should not be for smoking, together with strong support to help workers who want to quit smoking are shown to be effective.
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Hospitais Universitários , Prevenção do Hábito de Fumar , Adulto , Feminino , Humanos , Masculino , Recursos Humanos em Hospital , Avaliação de Programas e Projetos de SaúdeRESUMO
OBJECTIVE: To identify groups of patients receiving hospital-based educational programs, to determine whether the education was structured or ad hoc, and to analyse information on the structure, process and results of the programs. MATERIAL AND METHODS: We performed a cross-sectional study using a translated and adapted version of the National Standards for Diabetes Self-Management Education. Information was collected on structure (resources, availability of a written program and professional training), the process followed by the patient (baseline assessment, methodology, training courses, support materials and record of activities), patient outcomes (post-intervention assessment, tools, record of evaluation and results) and program results (number of patients/relatives included, regular assessment). RESULTS: Patient groups receiving education were: patients with chronic diseases, patients with treatable psychiatric disorders and patients with oncological and haematological processes. Most educational activities involved informative activities and technical skills training, both on-demand and integrated in care activity. Structured therapeutic education programs were aimed at patients/relatives with: diabetes, obesity, musculoskeletal diseases, AIDS, splenectomy, chronic obstructive pulmonary disease, hypertension and urinary incontinence. Not all programs had written guidelines or defined parameters with respect to structure, process and results. CONCLUSIONS: The application of quality standards to hospital educational programs is useful in detecting: patients receiving education and the quality, type and weaknesses of the programs studied. Software based on these standards may provide information on trends in patient education, identify opportunities for improvement and aid the evaluation of the impact of each educational activity on the quality indicators associated with each program.
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Hospitais Universitários/organização & administração , Educação de Pacientes como Assunto/normas , Doença Crônica , Estudos Transversais , Saúde da Família , Humanos , Transtornos Mentais , Educação de Pacientes como Assunto/métodos , Avaliação de Programas e Projetos de Saúde , Autocuidado , Espanha , Materiais de EnsinoRESUMO
OBJECTIVE: To perform a self-assessment of the Scientific Committee of the 25th Conference of the Spanish Society for Quality in Healthcare held in Barcelona on October 2007 in order to identify improvement areas for future Conferences. DESIGN: Applying PDCA methodology to the tasks undertaken by the Scientific Committee (SC) of the Conference. Plan: A description of the preparation of the conference based on the abstract management of the Scientific Committee. Do: description of the implementation. Check: evaluation of activities. A: improvement proposals for the coming conferences. RESULTS: The SC (22 people) worked in the abstracts management, book publishing and development of the scientific aspects of the Conference. Abstracts evaluation was conducted by 11 pairs of blind evaluators who analysed 348 oral communications and 457 posters, and 10.09% were rejected. Oral communications were performed in a total of 36 oral presentations sessions and 24 poster sessions. The book was published with the abstracts, addresses and the Conference opening and closing sessions. Awards: communications graded over 7.5 applied for an award and were reassessed by the SC. The on-line conference was also well received. CONCLUSIONS: The satisfaction with the Conference regarding the scientific activities was good; however, several areas of improvement were identified.
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Congressos como Assunto/normas , Qualidade da Assistência à Saúde , Congressos como Assunto/organização & administração , EspanhaRESUMO
BACKGROUND: Healthy People 2010 underscores the relevance of eliminating health disparities. Thus, it is paramount to create interventions that promote health for all individuals. PURPOSE: This study examined differences in rates of and reasons for ineligibility among non-Hispanic blacks and whites in a randomized controlled physical activity intervention study. METHODS: Participants (1245 adults) responded to community advertising for the research study. Eligibility at the four pre-randomization assessment sessions was determined by self-reported medical information, resting EKG, 7-Day Physical Activity Recall, fitness test and Stage of Change. We used t-tests to examine the rates of eligibility among participant subgroups. RESULTS: Blacks had higher rates of overall ineligibility (86.9%) than whites (75.1%; p < 0.01) and were more likely to be ineligible due to lack of interest or no-show at a pre-randomization appointment (35.4% vs. 24.3%; p < 0.01). Blacks were more likely to be ineligible for medical reasons after the telephone screen (16.3% vs. 7.8%; p = 0.01). LIMITATIONS: This study did not use a random sampling of potential participants from each of the racial/ethnic groups and thus, there is the potential for selection bias. CONCLUSIONS: Blacks were more likely to choose not to enroll in the study due to a lack of interest, but had similar rates of overall medical ineligibility to whites. This highlights the importance of strategies that enhance interest among blacks, who initially respond to recruitment advertising.