Pesquisa | BVS Violência e Saúde

1.

The cyclic dinucleotide c-di-AMP is an allosteric regulator of metabolic enzyme function.

Sureka, Kamakshi; Choi, Philip H; Precit, Mimi; Delince, Matthieu; Pensinger, Daniel A; Huynh, TuAnh Ngoc; Jurado, Ashley R; Goo, Young Ah; Sadilek, Martin; Iavarone, Anthony T; Sauer, John-Demian; Tong, Liang; Woodward, Joshua J.

Cell ; 158(6): 1389-1401, 2014 Sep 11.

Artigo em Inglês | MEDLINE | ID: mdl-25215494

2.

A tessellated lymphoid network provides whole-body T cell surveillance in zebrafish.

Robertson, Tanner F; Hou, Yiran; Schrope, Jonathan; Shen, Simone; Rindy, Julie; Sauer, John-Demian; Dinh, Huy Q; Huttenlocher, Anna.

Proc Natl Acad Sci U S A ; 120(20): e2301137120, 2023 05 16.

Artigo em Inglês | MEDLINE | ID: mdl-37155881

3.

Maintenance of heme homeostasis in Staphylococcus aureus through post-translational regulation of glutamyl-tRNA reductase.

Leasure, Catherine S; Grunenwald, Caroline M; Choby, Jacob E; Sauer, John-Demian; Skaar, Eric P.

J Bacteriol ; 205(9): e0017123, 2023 09 26.

Artigo em Inglês | MEDLINE | ID: mdl-37655914

4.

Characterization of an Autoinducing Peptide Signal Reveals Highly Efficacious Synthetic Inhibitors and Activators of Quorum Sensing and Biofilm Formation in Listeria monocytogenes.

West, Korbin H J; Ma, Stella V; Pensinger, Daniel A; Tucholski, Trisha; Tiambeng, Timothy N; Eisenbraun, Emma L; Yehuda, Avishag; Hayouka, Zvi; Ge, Ying; Sauer, John-Demian; Blackwell, Helen E.

Biochemistry ; 62(19): 2878-2892, 2023 10 03.

Artigo em Inglês | MEDLINE | ID: mdl-37699554

5.

Type I Interferon Signaling on Antigen-Presenting Cells Blunts Cell-Mediated Immunity toward Listeria monocytogenes.

Morrow, Zachary T; Sauer, John-Demian.

Infect Immun ; 91(7): e0054022, 2023 07 18.

Artigo em Inglês | MEDLINE | ID: mdl-37306593

6.

Listeria monocytogenes requires DHNA-dependent intracellular redox homeostasis facilitated by Ndh2 for survival and virulence.

Smith, Hans B; Lee, Kijeong; Freeman, Matthew J; Stevenson, David M; Amador-Noguez, Daniel; Sauer, John-Demian.

Infect Immun ; 91(10): e0002223, 2023 10 17.

Artigo em Inglês | MEDLINE | ID: mdl-37754681

7.

Phagocytes produce prostaglandin E2 in response to cytosolic Listeria monocytogenes.

McDougal, Courtney E; Morrow, Zachary T; Christopher, Tighe; Kim, Seonyoung; Carter, Drake; Stevenson, David M; Amador-Noguez, Daniel; Miller, Mark J; Sauer, John-Demian.

PLoS Pathog ; 17(9): e1009493, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-34555127

8.

PASTA kinase-dependent control of peptidoglycan synthesis via ReoM is required for cell wall stress responses, cytosolic survival, and virulence in Listeria monocytogenes.

Kelliher, Jessica L; Grunenwald, Caroline M; Abrahams, Rhiannon R; Daanen, McKenzie E; Lew, Cassandra I; Rose, Warren E; Sauer, John-Demian.

PLoS Pathog ; 17(10): e1009881, 2021 10.

Artigo em Inglês | MEDLINE | ID: mdl-34624065

9.

Carbomer-based adjuvant elicits CD8 T-cell immunity by inducing a distinct metabolic state in cross-presenting dendritic cells.

Lee, Woojong; Kingstad-Bakke, Brock; Paulson, Brett; Larsen, Autumn; Overmyer, Katherine; Marinaik, Chandranaik B; Dulli, Kelly; Toy, Randall; Vogel, Gabriela; Mueller, Katherine P; Tweed, Kelsey; Walsh, Alex J; Russell, Jason; Saha, Krishanu; Reyes, Leticia; Skala, Melissa C; Sauer, John-Demian; Shayakhmetov, Dmitry M; Coon, Joshua; Roy, Krishnendu; Suresh, M.

PLoS Pathog ; 17(1): e1009168, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-33444400

10.

Role of respiratory NADH oxidation in the regulation of Staphylococcus aureus virulence.

Schurig-Briccio, Lici A; Parraga Solorzano, Paola K; Lencina, Andrea M; Radin, Jana N; Chen, Grischa Y; Sauer, John-Demian; Kehl-Fie, Thomas E; Gennis, Robert B.

EMBO Rep ; 21(5): e45832, 2020 05 06.

Artigo em Inglês | MEDLINE | ID: mdl-32202364

11.

Listeria monocytogenes MenI Encodes a DHNA-CoA Thioesterase Necessary for Menaquinone Biosynthesis, Cytosolic Survival, and Virulence.

Smith, Hans B; Li, Tin Lok; Liao, Man Kit; Chen, Grischa Y; Guo, Zhihong; Sauer, John-Demian.

Infect Immun ; 89(5)2021 04 16.

Artigo em Inglês | MEDLINE | ID: mdl-33619030

12.

Cyclooxygenase-1 and -2 Play Contrasting Roles in Listeria-Stimulated Immunity.

Theisen, Erin; McDougal, Courtney E; Nakanishi, Masako; Stevenson, David M; Amador-Noguez, Daniel; Rosenberg, Daniel W; Knoll, Laura J; Sauer, John-Demian.

J Immunol ; 200(11): 3729-3738, 2018 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-29678951

13.

Broad detection of bacterial type III secretion system and flagellin proteins by the human NAIP/NLRC4 inflammasome.

Reyes Ruiz, Valeria M; Ramirez, Jasmine; Naseer, Nawar; Palacio, Nicole M; Siddarthan, Ingharan J; Yan, Brian M; Boyer, Mark A; Pensinger, Daniel A; Sauer, John-Demian; Shin, Sunny.

Proc Natl Acad Sci U S A ; 114(50): 13242-13247, 2017 12 12.

Artigo em Inglês | MEDLINE | ID: mdl-29180436

14.

Special Collection on the 28th Annual Midwest Microbial Pathogenesis Conference.

Sauer, John-Demian; Mandel, Mark J.

Infect Immun ; 92(4): e0007124, 2024 Apr 09.

Artigo em Inglês | MEDLINE | ID: mdl-38483162

15.

Mutation of the Transcriptional Regulator YtoI Rescues Listeria monocytogenes Mutants Deficient in the Essential Shared Metabolite 1,4-Dihydroxy-2-Naphthoate (DHNA).

Chen, Grischa Y; Kao, Cheng-Yen; Smith, Hans B; Rust, Drew P; Powers, Zachary M; Li, Alexandria Y; Sauer, John-Demian.

Infect Immun ; 88(1)2019 12 17.

Artigo em Inglês | MEDLINE | ID: mdl-31685546

16.

An immune response with a sweet tooth.

Sauer, John-Demian.

Nature ; 561(7721): 37-38, 2018 09.

Artigo em Inglês | MEDLINE | ID: mdl-30181623

17.

A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific inhibitors of the Listeria monocytogenes PASTA kinase PrkA.

Schaenzer, Adam J; Wlodarchak, Nathan; Drewry, David H; Zuercher, William J; Rose, Warren E; Striker, Rob; Sauer, John-Demian.

J Biol Chem ; 292(41): 17037-17045, 2017 10 13.

Artigo em Inglês | MEDLINE | ID: mdl-28821610

18.

The Listeria monocytogenes PASTA Kinase PrkA and Its Substrate YvcK Are Required for Cell Wall Homeostasis, Metabolism, and Virulence.

Pensinger, Daniel A; Boldon, Kyle M; Chen, Grischa Y; Vincent, William J B; Sherman, Kyle; Xiong, Meng; Schaenzer, Adam J; Forster, Emily R; Coers, Jörn; Striker, Rob; Sauer, John-Demian.

PLoS Pathog ; 12(11): e1006001, 2016 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-27806131

19.

Listeria monocytogenes cytosolic metabolism promotes replication, survival, and evasion of innate immunity.

Chen, Grischa Y; Pensinger, Daniel A; Sauer, John-Demian.

Cell Microbiol ; 19(10)2017 10.

Artigo em Inglês | MEDLINE | ID: mdl-28656691

20.

In Silico Screen and Structural Analysis Identifies Bacterial Kinase Inhibitors which Act with ß-Lactams To Inhibit Mycobacterial Growth.

Wlodarchak, Nathan; Teachout, Nathan; Beczkiewicz, Jeffrey; Procknow, Rebecca; Schaenzer, Adam J; Satyshur, Kenneth; Pavelka, Martin; Zuercher, William; Drewry, David; Sauer, John-Demian; Striker, Rob.

Mol Pharm ; 15(11): 5410-5426, 2018 11 05.

Artigo em Inglês | MEDLINE | ID: mdl-30285456

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