Detalhe da pesquisa
1.
A high quality, industrial data set for binding affinity prediction: performance comparison in different early drug discovery scenarios.
J Comput Aided Mol Des
; 36(10): 753-765, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36153472
2.
Discovery of the first low-shift positive allosteric modulators for the muscarinic M1 receptor.
Bioorg Med Chem Lett
; 27(24): 5415-5419, 2017 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29146472
3.
Local application of engineered insulin-like growth factor I mRNA demonstrates regenerative therapeutic potential in vivo.
Mol Ther Nucleic Acids
; 34: 102055, 2023 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37928443
4.
CEP-26401 (irdabisant), a potent and selective histamine H3 receptor antagonist/inverse agonist with cognition-enhancing and wake-promoting activities.
J Pharmacol Exp Ther
; 340(1): 124-33, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22001260
5.
Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: identification of a potent and selective 5-HT6 receptor antagonist showing activity in rat social recognition test.
Bioorg Med Chem Lett
; 22(3): 1421-6, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22226656
6.
Novel brain penetrant benzofuropiperidine 5-HT6 receptor antagonists.
Bioorg Med Chem Lett
; 22(1): 120-3, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22153937
7.
Correlation between ex vivo receptor occupancy and wake-promoting activity of selective H3 receptor antagonists.
J Pharmacol Exp Ther
; 325(3): 902-9, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18305012
8.
Transposition of three amino acids transforms the human metabotropic glutamate receptor (mGluR)-3-positive allosteric modulation site to mGluR2, and additional characterization of the mGluR2-positive allosteric modulation site.
J Pharmacol Exp Ther
; 326(1): 240-51, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18430863
9.
The phosphatidylinositol 3-kinase inhibitor LY 294002 inhibits GlyT1-mediated glycine uptake.
Brain Res
; 1227: 42-51, 2008 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18621031
10.
Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: Implication in emotional responses and central disinhibition.
Brain Res
; 1197: 47-62, 2008 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-18242587
11.
Allosteric approaches to the targeting of G-protein-coupled receptors for novel drug discovery: a critical assessment.
Biochem Pharmacol
; 74(3): 383-91, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17572390
12.
Distribution and abundance of metabotropic glutamate receptor subtype 2 in rat brain revealed by [3H]LY354740 binding in vitro and quantitative radioautography: correlation with the sites of synthesis, expression, and agonist stimulation of [35S]GTPgammas binding.
J Comp Neurol
; 487(1): 15-27, 2005 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15861463
13.
Metabotropic glutamate receptors: potential drug targets for the treatment of schizophrenia.
Curr Drug Targets CNS Neurol Disord
; 1(3): 261-81, 2002 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12769619
14.
Group II mGlu receptor activation suppresses norepinephrine release in the ventral hippocampus and locomotor responses to acute ketamine challenge.
Neuropsychopharmacology
; 28(9): 1622-32, 2003 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-12825094
15.
Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor.
J Med Chem
; 47(18): 4595-9, 2004 Aug 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-15317469
16.
5-HT6 receptor antagonists as potential therapeutics for cognitive impairment.
Curr Top Med Chem
; 10(2): 207-21, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20166958
17.
Detection of low level histamine H3 receptor occupancy by autoradiography.
J Neurosci Methods
; 185(1): 70-5, 2009 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19765611
18.
Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities.
Biochem Pharmacol
; 78(8): 1035-42, 2009 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19549510
19.
Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.
Bioorg Med Chem Lett
; 17(5): 1386-91, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17210250
20.
3-(2-Ethoxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy}phenyl)propanoic acid: a brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 (mGluR2).
Bioorg Med Chem Lett
; 15(9): 2389-93, 2005 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15837331