1.
Clin Infect Dis
; 40(12): e113-6, 2005 Jun 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15909253
RESUMO
Linezolid, an oxazolidinone antibiotic, inhibits bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA). We studied 3 patients who experienced lactic acidosis while receiving linezolid therapy. The toxicity may have been caused by linezolid binding to mitochondrial 16S rRNA. Genetic polymorphisms may have contributed to the toxicity in 2 patients.