Health hazards of preconception phthalate exposure: A scoping review of epidemiology studies.

There is a close relationship between preconception health and maternal and child health outcomes, and the consequences may be passed down from generation to generation. In 2018, Lancet published three consecutive articles emphasizing the importance of the preconception period. Phthalic acid ester (PAE) exposure during this period may affect gametogenesis and epigenetic information in gametophytes, thereby affecting embryonic development and offspring health. Therefore, this article reviews the effects of parental preconception PAE exposure on reproductive/birth outcomes and offspring health, to provide new evidence on this topic. We searched Web of Science, MEDLINE (through PubMed), the China National Knowledge Infrastructure (CNKI), ScienceDirect, and the VIP Journal Library from the date of database establishment to July 3, 2024. Finally, 12 articles were included. Three studies investigated the health hazards (effects on birth weight, abortion, etc.) of women's preconception PAE exposure. Nine studies involved both parents. Nine studies considered the impacts of PAE preconception exposure on reproductive/birth outcomes, focusing on birth weight, pregnancy loss, preterm birth, embryo quality, and placental weight. Three studies considered the impacts of preconception PAE exposure on offspring behavior. The results of this review suggested that parental preconception PAE exposure may have an impact on reproductive/birth outcomes and offspring behavior, including birth weight, child behavior, and dietary behavior. However, studies on the health hazards of preconception PAE exposure are relatively scarce, and the outcomes of current studies are varied. It is necessary to use systematic reviews to verify an accurate research question to provide recommendations for public health policy making.

Antioxidant vitamins' modification of the adverse health effects induced by phthalate exposure: A scoping review of epidemiological and experimental studies.

The exposure to and health hazards of phthalates have received abundant attention. However, reducing phthalate exposure and further decreasing the associated health risks are difficult. Nonetheless, it is important to actively seek relevant measures. Recently, antioxidant vitamins have been frequently mentioned to improve phthalate-related issues. This scoping review summarizes the existing epidemiological and experimental studies on the interaction of phthalates with antioxidant vitamins. Through a systematic search, sparse epidemiological studies explored the effects of interaction between phthalates and vitamins on reproduction, the endocrine, respiratory, and nervous system and human aging. Four prospective studies were conducted in China, the United States, Canada and Netherlands. Only one study from Netherlands focused on the female reproductive system.The other three studies focused on neurological damage to fetuses caused by phthalate exposure, and its mitigation by vitamin supplementation during pregnancy. Four cross-sectional studies were conducted based on the United States National Health and Nutrition Examination Survey database. These studies involved hazards in different systems and interactions with different vitamins. Overall, epidemiological evidence suggests that antioxidant vitamins such as vitamin A, B, D, and folic acid probably may alter the health hazards induced by phthalate exposure. Current animal studies often focus on three phthalates, DBP, DEHP and DIDP,2 and most commonly, the first two phthalates. These chemicals cause reproductive, urinary, digestive and neurodevelopmental damage; the antioxidant vitamin C, E and B could mitigate the harm caused by phthalates. Possible mechanisms involve reducing oxidative stress, removing methylation,etc. Determining whether these mechanisms are similar to those in humans requires a rigorous experimental study.

Exploring noninvasive matrices for assessing long-term exposure to phthalates: a scoping review.

The phthalic acid esters (PAEs) are one class of the most abundant and frequently studied pseudo-persistent organic pollutants. Noninvasive urine is an effective substrate for evaluating PAE exposure, but repeated sampling is needed to overcome this bias. This adds much work to on-site collection and the cost of detection increases exponentially. Therefore, the aim of this study was to conduct a scope review to describe the detection methods and validity of the use of other noninvasive matrices, such as nails and hair, for assessing long-term exposure to PAEs. The PubMed, Web of Science and China National Knowledge Infrastructure (CNKI), electronic databases were searched from 1 January 2000 to 3 April 2024, and 12 studies were included. Nine and three studies used hair and nails, respectively, as noninvasive matrices for detecting PAE exposure. Five articles compared the results of nail or hair and urine tests for validity of the assessment of PAE exposure. The preprocessing and detection methods for these noninvasive samples are also described. The results of this review suggest that, compared with nails, hair may be more suitable as a noninvasive alternative matrix for assessing long-term exposure to PAEs. However, sample handling procedures such as the extraction and purification of compounds from hair are not uniform in various studies; therefore, further exploration and optimization of this process, and additional research evidence to evaluate its effectiveness, are needed to provide a scientific basis for the promotion and application of hair detection methods for assessing long-term PAE exposure levels.