Comparison of pollution status and source apportionment for PCBs and OCPs of indoor dust from an industrial city.

In this study, the pollution status of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) was investigated in indoor and outdoor dust from three different functional areas of Hefei, China. The relationship between the concentrations of PCBs and OCPs and different influencing factors in dwellings was studied. The results showed that the concentrations of PCBs and OCPs were higher in samples from dwellings with higher smoking frequency, lower cleaning frequency, higher floors and smaller household size. The results of Spearman's correlation coefficient analysis indicated that PCBs and OCPs were not consistently associated with each other, while sources of low-chlorinated PCBs and high-chlorinated PCBs were different. Scanning electron microscopy (SEM) shows the shape of indoor dust was a mixture of blocky, flocculated, spherical structures, and irregular shapes. The results of principal component analysis (PCA) and positive matrix factorization model (PMF) showed that the PCBs and OCPs of indoor dust came from both indoor and outdoor sources between local and regional transport. Carbon (δ13C) and Nitrogen (δ15N) stable isotope results indicate or show that the indoor dust (δ13C: - 24.37‰, δ15N: 6.88‰) and outdoor dust (δ13C: - 12.65‰, δ15N: 2.558‰) is derived from fossil fuel, coal combustion, road dust, fly ash, C4 biomass and soil. Potential source contribution factor (PSCF) and concentration weighted-trajectory analysis suggest that sources of pollutants were local and regional transport from surrounding provinces and marine emissions. The average daily dose (adult: 8.20E-04, children: 2.37E-03) of pollutants and the carcinogenic risks (adult: 1.23E-02, children: 2.65E-02) were relatively greater for children than adults. This study demonstrates the utility of SEM to characterize indoor dust morphology while combining PMF, PSCF, and stable isotope methods in identifying indoor PCBs and OCPs sources and regions.

Distribution, sources and health risk of PAHs in urban air-conditioning dust from Hefei, East China.

In recent decades, indoor air quality (IAQ) has become one of the most important human health issues. The potential properties and potential health hazards of polycyclic aromatic hydrocarbons (PAHs) are associated with their long-term residues, bioaccumulation and semivolatility, and they can also be transferred through a variety of media, such as the atmosphere, water and soil. Dust particles from indoor and outdoor emission sources adhere to A-C filters and can represent air quality to a certain extent. However, few studies have focused on PAHs in A-C filter dust in Hefei, China. In this study, 16 PAHs were selected, dust samples were collected from A-C filters from three different functional districts, and GC-MS analysis of the samples was performed. The concentration of the ∑16PAHs ranged from 7.34 to 326.84 µg g-1, 5.07-15.34 µg g-1, 4.09-47.26 µg g-1 and 0.97-13.38 µg g-1 in dust samples from the Administrative District (AD), Industrial District (ID), Commercial District (CD) and Outdoors (OD), respectively. The total PAH concentration in A-C dust was much higher than that in dust deposited outdoors in the urban area. The percentage of 5-6 ring PAHs accounted for more than 70% of the ∑16PAHs, which shows that the PAHs in A-C dust mainly come from pyrolysis rather than a diagenetic source. Principal component analysis (PCA) and diagnostic ratios were used in a source analysis, and the results indicated that the main PAHs emission sources in the different functional districts were coal, wood and biomass combustion. The incremental lifetime cancer risk (ILCR) values indicated a medium to high potential carcinogenic risk for adults and children exposed to dust with PAHs. Particularly, skin contact and ingestion of carcinogenic PAHs from dust are the major exposure pathways and present an exposure risk that is four to five orders of magnitude higher than the risk of inhalation.

COVID-19 lockdown measures affect polycyclic aromatic hydrocarbons distribution and sources in sediments of Chaohu Lake, China.

The COVID-19 pandemic has profoundly impacted human activities and the environment globally. The lockdown measures have led to significant changes in industrial activities, transportation, and human behavior. This study investigates how the lockdown measures influenced the distribution of polycyclic aromatic hydrocarbons (PAHs) in the sediments of Chaohu Lake, a semi-enclosed lake. Surface sediment samples were collected in summer of 2020 (lockdown have just been lifted) and 2022 and analyzed for 16 priority PAHs. The range of ΣPAHs concentrations remained similar between 2020 (158.19-1693.64 ng·g-1) and 2022 (148.86-1396.54 ng·g-1). Among the sampling sites, the west lake exhibited similar PAHs concentrations characteristics over the two years, with higher levels observed in areas near Hefei City. However, the east lake exhibited increased ΣPAHs concentrations in 2022 compared to 2020, especially the area near ship factory. PAHs source analysis using principal component analysis-multiple linear regression (PCA-MLR) revealed an increased proportion of petroleum combustion sources in 2022 compared to 2020. The isotope analysis results showed that organic matter (OM) sources in the western lake remained relatively stable over the two years, with sewage discharge dominating. In contrast, the eastern lake experienced a shift in OM sources from sewage to C3 plants, potentially contributing to the increased PAH levels observed in the eastern lake sediments. Ecological risk assessment revealed low to moderate risk in both 2020 and 2022. Health risk evaluation indicated little difference in incremental lifetime cancer risk (ILCR) values between the two years, with only benzo[a]pyrene (BaP) posing a high risk among the carcinogenic PAHs. Children generally faced higher health risks compared to adults. This study reveals pandemic-induced changes in PAH pollution and sources in lake sediments, offering new insights into the impact of human activities on persistent organic pollutants, with implications for future pollution control strategies.

Potential ecological and health risks of heavy metals for indoor and corresponding outdoor dust in Hefei, Central China.

The harm caused by indoor dust has received increasing attention in recent years. However, current studies have ignored comparisons with the corresponding outdoor dust. This study aimed to investigate the distribution of heavy metals in indoor and corresponding outdoor dust and the ecological and health risks they pose in Hefei, Central China. We analyzed O/I (outdoor/indoor concentration ratios) values, background comparison, and correlation analysis (heavy metal concentrations vs. particle size) and found that Cu, Zn, and Cd mainly existed in indoor sources, while V, Co, and As mainly existed in outdoor sources, and both family sizes and floor number influenced the variation of O/I. Through a new potential ecological risk assessment method, we determined that Cd risk levels in indoor and outdoor dust were extreme and high to extreme, respectively. Additionally, the carcinogenic risks of Ni, As, and Cr were not negligible. The risk of indoor dust was higher than that of outdoor dust for the heavy metals studied, implying a poor indoor environment. Notably, indoor dust from families with smaller sizes, lower floors, and smokers had higher ecological and carcinogenic risks.

Spatial distribution, driving factors and health risks of fine particle-bound polycyclic aromatic hydrocarbons (PAHs) from indoors and outdoors in Hefei, China.

Atmospheric particulate matter, especially in urban and industrial environments, can act as a source of different organic pollutants that can pose significant health impacts to residents. However, the pollution status and transport mechanisms of fine particle-bound polycyclic aromatic hydrocarbons (PAHs) in indoor and outdoor environments are uncertain. This study aimed to determine the spatial distribution and morphological characteristics of fine particle-bound PAHs and analyze the factors (source contributions and backward trajectories) that influence their concentrations. The results showed that mean concentrations of 16 PAHs were higher in indoor dust as compared to outdoor dust. In addition, the lowest concentrations of the 16 PAHs were found on the 11-20th floor, with smoking households > nonsmoking households (except Nap, Acy, and Ace). The 2-3 ring PAHs were more prominent in households with cooking activities. The particle size distribution showed that most of the particles were <62 µm in diameter, indicating that the indoor particles were smaller in size. Furthermore, the range of δ13C values in the outdoor dust (-30.17 ~ -28.63 ‰) samples was significantly lower than in indoor dust (-28.29 ~ -22.53 ‰). The results based on diagnostic ratios, positive matrix factorization (PMF) analysis and backward trajectory model analysis suggested that the sources of PAHs in indoor and outdoor dust were mixed, originated both locally and from neighboring provinces transported over long distances, especially concentrated in the Yangtze River Delta area. Finally, carcinogenic risk values for indoor dust were greater than those for outdoor dust. Therefore, it is recommended that local governments and industries with high PAH emissions should implement proper protocols to monitor and minimize the pollution levels of PAHs in the urban industrial environment in order to mitigate their health risks.

Characteristics of indoor dust in an industrial city: Comparison with outdoor dust and atmospheric particulates.

There is a considerable connection between indoor and outdoor environments. However, few studies have explored their intrinsic relationship until now. This study conducted morphologic observation, heavy metal monitoring and isotopes analysis in indoor and outdoor dust, as well as the atmospheric particulates in Hefei. Morphologic analysis demonstrated atmospheric particulates were affected by fly ash and construction, road dust mainly came from automobile exhaust and indoor dust particles were interfered by multiple sources, including the secondary reaction of fly ash. Chemical speciation analysis of heavy metals showed the exchange of heavy metals between atmospheric particulates and indoor dust was dominated by non-residual metals, while the exchange between road dust and indoor dust tended to rely on residual metals. The assessment results of heavy metals in particulates showed that indoor carcinogenic risks were greater than outdoor for children, however, for adults, outdoor carcinogenic risks were greater than indoor. Stable isotopes analysis indicated carbon in the dust outside buildings was derived from flying dust, and atmospheric particulates might derive from vehicle exhaust, or partly from natural gas. While sulfur in atmospheric particulates was derived mainly from coal combustion. The release from indoor activities, especially natural gas exhaust emitted from cooking had a certain impact on atmospheric particulates.

Ni-Foam-Structured Ni-Al2O3 Ensemble as an Efficient Catalyst for Gas-Phase Acetone Hydrogenation to Isopropanol.

The free-standing Ni-Al2O3 ensemble derived from NiAl-layered double hydroxides (NiAl-LDHs) grown onto a Ni-foam has been developed for the exothermic gas-phase acetone hydrogenation to isopropanol. This approach works effectively and efficiently to achieve a unique combination of high activity/selectivity and enhanced heat/mass transfer stemmed from the Ni-foam. The outstanding catalyst is obtained by direct reduction of the un-calcined NiAl-LDH/Ni-foam, with a high turnover frequency of 0.90 s-1, being capable of converting 90.8% acetone into isopropanol with almost 100% selectivity under stoichiometric H2/acetone molar ratio, atmospheric pressure at 80 °C, and a WHSVacetone of 10 h-1. The catalyst derivation using the un-calcined NiAl-LDH/Ni-foam enables the Ni nanoparticles to be intertwined with Al2O3 to form a large Ni-Al2O3 interface, without interruption of impurities such as irreducible NiO (in the case of calcined NiAl-LDH/Ni-foam samples), which markedly improves the strong acetone adsorption next to the Ni0 hydrogenation sites, thereby leading to a dramatic improvement of catalyst activity.

Inhibition of cardiomyocyte apoptosis post-acute myocardial infarction through the efficient delivery of microRNA-24 by silica nanoparticles.

MicroRNA-24 (miR-24) is an apoptosis suppressor miRNA downregulated in cardiomyocytes after acute myocardial infarction (AMI). However, due to the lack of effective delivery strategies, the role of anti-apoptotic miR-24 in cardiomyocytes post-acute myocardial infarction remains unexplored. Here, we used a silica nanoparticle-based polyelectrolyte (polyethylenimine, PEI) delivery system to study the role of miR-24. These particles with good biocompatibility could be efficiently internalized into cells and release the loaded miR-24 into the cytoplasm. As a result, the overexpression of miR-24 resulted in the inhibition of the pro-apoptotic Bim, thereby inhibiting cardiomyocyte apoptosis in vitro. Furthermore, in vivo experiments revealed that over-expressed miR-24 additionally significantly improves ventricular remodeling and cardiac function in Sprague-Dawley (SD) rats after coronary artery ligation. In summary, our novel delivery system serves as a therapeutic miRNA formulation for cardiovascular disease treatment.

Source identification of heavy metals and stable carbon isotope in indoor dust from different functional areas in Hefei, China.

Dust on air conditioning filters can represent the re-suspended particulate matter in indoor air, which may pose potential health risks to humans. However, source identification and influence factors of indoor dust are controversial. The present study investigated the distribution of Cd, Cr, Mn, Ni, Pb, Sb, V, and Zn, as well as stable carbon isotope, in indoor dust from three different functional zones in Hefei to discuss the sources and influence factors of indoor dust. PCA analysis of heavy metals showed that indoor sources (such as cooking and smoking) were the main sources. Negative correlation appeared between family size and heavy metal concentrations. This was because people acted as a sink of pollutants. Concentration analysis of heavy metals revealed that smoking and cooking had weak relevance with heavy metal concentrations. While through the δ13C analysis, cooking had a significant correlation with δ13C of indoor dust, instructing that cooking was a significant source of indoor dust. Besides, smoking also had a certain correlation with δ13C of indoor dust, instructing that smoking was one of the sources of indoor dust.

Characteristics and health risk assessment of heavy metals in indoor dust from different functional areas in Hefei, China.

Metals in indoor dust pose potential health risks to humans. Dust deposition on air conditioner filters can represent the resuspended particulate matter in indoor air. However, few studies have examined this until now. This study investigated the total concentrations and different chemical fractionations of Cd, Cr, Mn, Ni, Pb, Sb, V, and Zn in indoor dust from three different functional zones (the Chief District, Commercial District (CmD), and Industrial District) in Hefei. The mean metal concentrations in indoor dust decreased in the following order: Zn > Mn > Pb > Cr > Ni > V > Cd > Sb. Cd, Pb, and Zn mainly existed in the mobile fraction. Cr and V mainly existed in the residual fraction. The enrichment factor and geo-accumulation index values of heavy metals were all ranked in the order of Cd > Zn > Pb > Sb > Ni > Cr > V, and these values in indoor dust were larger than those in outdoor dust. In addition, the enrichment patterns of these elements were similar in the three functional areas. The orders of non-carcinogenic risk (hazard index; HI) for the different functional areas for children were roughly the same, but there were clear differences for adults. In general, all the HIs were less than 1, which were within the internationally recognized safe range. The total carcinogenic risk (TR) was in the order of Cr > Pb > Cd for both children and adults in the three functional zones. The TRs from Cr exposure were not negligible. The TRs were significantly higher in the CmD.