Pesquisa | BVS Violência e Saúde

1.

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer.

Lee, Suk Hyung; Hu, Wenhuo; Matulay, Justin T; Silva, Mark V; Owczarek, Tomasz B; Kim, Kwanghee; Chua, Chee Wai; Barlow, LaMont J; Kandoth, Cyriac; Williams, Alanna B; Bergren, Sarah K; Pietzak, Eugene J; Anderson, Christopher B; Benson, Mitchell C; Coleman, Jonathan A; Taylor, Barry S; Abate-Shen, Cory; McKiernan, James M; Al-Ahmadie, Hikmat; Solit, David B; Shen, Michael M.

Cell ; 173(2): 515-528.e17, 2018 04 05.

Artigo em Inglês | MEDLINE | ID: mdl-29625057

2.

Identification of causal genetic drivers of human disease through systems-level analysis of regulatory networks.

Chen, James C; Alvarez, Mariano J; Talos, Flaminia; Dhruv, Harshil; Rieckhof, Gabrielle E; Iyer, Archana; Diefes, Kristin L; Aldape, Kenneth; Berens, Michael; Shen, Michael M; Califano, Andrea.

Cell ; 159(2): 402-14, 2014 Oct 09.

Artigo em Inglês | MEDLINE | ID: mdl-25303533

3.

Identification of Causal Genetic Drivers of Human Disease through Systems-Level Analysis of Regulatory Networks.

Chen, James C; Alvarez, Mariano J; Talos, Flaminia; Dhruv, Harshil; Rieckhof, Gabrielle E; Iyer, Archana; Diefes, Kristin L; Aldape, Kenneth; Berens, Michael; Shen, Michael M; Califano, Andrea.

Cell ; 166(4): 1055, 2016 Aug 11.

Artigo em Inglês | MEDLINE | ID: mdl-27518566

4.

Inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner.

Shao, Zhengping; Lee, Brian J; Zhang, Hanwen; Lin, Xiaohui; Li, Chen; Jiang, Wenxia; Chirathivat, Napon; Gershik, Steven; Shen, Michael M; Baer, Richard; Zha, Shan.

Proc Natl Acad Sci U S A ; 120(31): e2301972120, 2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37487079

5.

Intra-epithelial non-canonical Activin A signaling safeguards prostate progenitor quiescence.

Cambuli, Francesco; Foletto, Veronica; Alaimo, Alessandro; De Felice, Dario; Gandolfi, Francesco; Palumbieri, Maria Dilia; Zaffagni, Michela; Genovesi, Sacha; Lorenzoni, Marco; Celotti, Martina; Bertossio, Emiliana; Mazzero, Giosuè; Bertossi, Arianna; Bisio, Alessandra; Berardinelli, Francesco; Antoccia, Antonio; Gaspari, Marco; Barbareschi, Mattia; Fiorentino, Michelangelo; Shen, Michael M; Loda, Massimo; Romanel, Alessandro; Lunardi, Andrea.

EMBO Rep ; 23(5): e54049, 2022 05 04.

Artigo em Inglês | MEDLINE | ID: mdl-35253958

6.

Atg7 cooperates with Pten loss to drive prostate cancer tumor growth.

Santanam, Urmila; Banach-Petrosky, Whitney; Abate-Shen, Cory; Shen, Michael M; White, Eileen; DiPaola, Robert S.

Genes Dev ; 30(4): 399-407, 2016 Feb 15.

Artigo em Inglês | MEDLINE | ID: mdl-26883359

7.

Prostate cancer cell heterogeneity and plasticity: Insights from studies of genetically-engineered mouse models.

Li, Weiping; Shen, Michael M.

Semin Cancer Biol ; 82: 60-67, 2022 07.

Artigo em Inglês | MEDLINE | ID: mdl-34147640

8.

Functional redundancy of type I and type II receptors in the regulation of skeletal muscle growth by myostatin and activin A.

Lee, Se-Jin; Lehar, Adam; Liu, Yewei; Ly, Chi Hai; Pham, Quynh-Mai; Michaud, Michael; Rydzik, Renata; Youngstrom, Daniel W; Shen, Michael M; Kaartinen, Vesa; Germain-Lee, Emily L; Rando, Thomas A.

Proc Natl Acad Sci U S A ; 117(49): 30907-30917, 2020 12 08.

Artigo em Inglês | MEDLINE | ID: mdl-33219121

9.

Prostate organogenesis: tissue induction, hormonal regulation and cell type specification.

Toivanen, Roxanne; Shen, Michael M.

Development ; 144(8): 1382-1398, 2017 04 15.

Artigo em Inglês | MEDLINE | ID: mdl-28400434

10.

ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm.

Ellis, Pamela S; Burbridge, Sarah; Soubes, Sandrine; Ohyama, Kyoji; Ben-Haim, Nadav; Chen, Canhe; Dale, Kim; Shen, Michael M; Constam, Daniel; Placzek, Marysia.

Development ; 142(22): 3821-32, 2015 Nov 15.

Artigo em Inglês | MEDLINE | ID: mdl-26417042

11.

Molecular genetics of prostate cancer: new prospects for old challenges.

Shen, Michael M; Abate-Shen, Cory.

Genes Dev ; 24(18): 1967-2000, 2010 Sep 15.

Artigo em Inglês | MEDLINE | ID: mdl-20844012

12.

Inactivation of p53 and Pten promotes invasive bladder cancer.

Puzio-Kuter, Anna M; Castillo-Martin, Mireia; Kinkade, Carolyn W; Wang, Xi; Shen, Tian Huai; Matos, Tulio; Shen, Michael M; Cordon-Cardo, Carlos; Abate-Shen, Cory.

Genes Dev ; 23(6): 675-80, 2009 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-19261747

13.

Cripto-1 ablation disrupts alveolar development in the mouse mammary gland through a progesterone receptor-mediated pathway.

Klauzinska, Malgorzata; McCurdy, David; Rangel, Maria Cristina; Vaidyanath, Arun; Castro, Nadia P; Shen, Michael M; Gonzales, Monica; Bertolette, Daniel; Bianco, Caterina; Callahan, Robert; Salomon, David S; Raafat, Ahmed.

Am J Pathol ; 185(11): 2907-22, 2015 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-26429739

14.

Cancer: The complex seeds of metastasis.

Shen, Michael M.

Nature ; 520(7547): 298-9, 2015 Apr 16.

Artigo em Inglês | MEDLINE | ID: mdl-25830892

15.

ETV4 promotes metastasis in response to activation of PI3-kinase and Ras signaling in a mouse model of advanced prostate cancer.

Aytes, Alvaro; Mitrofanova, Antonina; Kinkade, Carolyn Waugh; Lefebvre, Celine; Lei, Ming; Phelan, Vanessa; LeKaye, H Carl; Koutcher, Jason A; Cardiff, Robert D; Califano, Andrea; Shen, Michael M; Abate-Shen, Cory.

Proc Natl Acad Sci U S A ; 110(37): E3506-15, 2013 Sep 10.

Artigo em Inglês | MEDLINE | ID: mdl-23918374

16.

FGF signaling in prostate tumorigenesis--new insights into epithelial-stromal interactions.

Abate-Shen, Cory; Shen, Michael M.

Cancer Cell ; 12(6): 495-7, 2007 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-18068626

17.

A luminal epithelial stem cell that is a cell of origin for prostate cancer.

Wang, Xi; Kruithof-de Julio, Marianna; Economides, Kyriakos D; Walker, David; Yu, Hailong; Halili, M Vivienne; Hu, Ya-Ping; Price, Sandy M; Abate-Shen, Cory; Shen, Michael M.

Nature ; 461(7263): 495-500, 2009 Sep 24.

Artigo em Inglês | MEDLINE | ID: mdl-19741607

18.

The roots of cancer: stem cells and the basis for tumor heterogeneity.

Shibata, Maho; Shen, Michael M.

Bioessays ; 35(3): 253-60, 2013 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-23027425

19.

Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin.

Guardiola, Ombretta; Lafuste, Peggy; Brunelli, Silvia; Iaconis, Salvatore; Touvier, Thierry; Mourikis, Philippos; De Bock, Katrien; Lonardo, Enza; Andolfi, Gennaro; Bouché, Ann; Liguori, Giovanna L; Shen, Michael M; Tajbakhsh, Shahragim; Cossu, Giulio; Carmeliet, Peter; Minchiotti, Gabriella.

Proc Natl Acad Sci U S A ; 109(47): E3231-40, 2012 Nov 20.

Artigo em Inglês | MEDLINE | ID: mdl-23129614

20.

Regulation of extra-embryonic endoderm stem cell differentiation by Nodal and Cripto signaling.

Kruithof-de Julio, Marianna; Alvarez, Mariano J; Galli, Antonella; Chu, Jianhua; Price, Sandy M; Califano, Andrea; Shen, Michael M.

Development ; 138(18): 3885-95, 2011 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-21862554

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