Applications of ROS-InducedZr-MOFs Platform in Multimodal Synergistic Therapy.

BACKGROUND: Metal-organic frameworks (MOFs) possess adjustable aperture, high load capacities, tailorable structures, and excellent biocompatibilities for their use as drug delivery carries in cancer therapy. Until now, Zr-MOFs, in particular, combine optimal stability towards hydrolysis and post synthetic modification with low toxicity, and are widely studied for their excellentbiological performance. INTRODUCTION: This review comprises the exploration of Zr-MOFs as drug delivery devices (DDSs) with a focus on various new methods, including chemotherapy (CT), photodynamic therapy (PDT), photothermal therapy (PTT), sonodynamic therapy (SDT), radiotherapy, immunotherapy, gene therapy and related combined therapies, which all generate reactive oxygen species (ROS) to achieve high efficiency of tumor therapy. CONCLUSION: We described and summarized these pertinent examples of the therapeutic mechanisms and highlighted the antitumor effects of their biological application both in vitro and in vivo. The perspectives on their future applications and the analogous challenge of the Zr-MOFs materials are given.

Correction: Two Ln-based metal-organic frameworks based on the 5-(1H-1,2,4-triazol-1-yl)-1,3-benzenedicarboxylic acid ligand: syntheses, structures, and photocatalytic properties.

[This corrects the article DOI: 10.1039/D0RA07159E.].

Two Ln-based metal-organic frameworks based on the 5-(1H-1,2,4-triazol-1-yl)-1,3-benzenedicarboxylic acid ligand: syntheses, structures, and photocatalytic properties.

Two new metal-organic frameworks (MOFs) having the formula [Ln2(H2O)3(L)3·3H2O] n (Ln = Sm for MOF-Sm and Tb for MOF-Tb) have been synthesized solvothermally by reacting LnCl3·6H2O with 5-(1H-1,2,4-triazol-1-yl)-1,3-benzenedicarboxylic acid (H2L) and characterized. Single crystal X-ray analyses for MOF-Sm and MOF-Tb revealed that both MOFs are isostructural and display a (6,8)-connected 3D structure with a point symbol of (35·44·66)(35·46·517). The natures of weak interactions existing in both MOFs have been assessed using Hirshfeld surface analyses and fingerprint plots. The utility of MOF-Sm as a photocatalyst for the safe photodegradation of the model aromatic dye methyl violet (MV) is also checked. The photocatalysis results showed that MOF-Sm offers reasonable photocatalytic degradation of this dye. The plausible photocatalytic mechanism of MOF-Sm aided photocatalysis has been explained with the help of band gap calculations using density of states (DOS) and partial DOS plots.