Detalhe da pesquisa
1.
Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment.
Eur J Clin Pharmacol
; 78(1): 65-73, 2022 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-34415382
2.
Effects of itraconazole and rifampicin on the single-dose pharmacokinetics of the nonsteroidal mineralocorticoid receptor blocker esaxerenone in healthy Japanese subjects.
Br J Clin Pharmacol
; 86(10): 2070-2079, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32250463
3.
Pharmacokinetics, Metabolism, and Excretion of [14C]Esaxerenone, a Novel Mineralocorticoid Receptor Blocker in Humans.
Drug Metab Dispos
; 47(3): 340-349, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30541878
4.
Incidence of metachronous gastric cancer in patients whose primary gastric neoplasms were discovered after Helicobacter pylori eradication.
Gastrointest Endosc
; 89(6): 1152-1159.e1, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30825537
5.
Single- and multiple-dose escalation study to assess pharmacokinetics, pharmacodynamics and safety of oral esaxerenone in healthy Japanese subjects.
Br J Clin Pharmacol
; 84(8): 1821-1829, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29688582
6.
Correction to: Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment.
Eur J Clin Pharmacol
; 78(1): 75, 2022 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-34494163
7.
Nrf2 Regulates the Risk of a Diesel Exhaust Inhalation-Induced Immune Response during Bleomycin Lung Injury and Fibrosis in Mice.
Int J Mol Sci
; 18(3)2017 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28304344
8.
Exposure-response analysis of the efficacy and safety of esaxerenone, a novel nonsteroidal mineralocorticoid receptor blocker, in hypertensive patients with or without diabetic kidney disease.
Drug Metab Pharmacokinet
; 55: 100535, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38245949
9.
Physiologically Based Pharmacokinetic Absorption Model for Pexidartinib to Evaluate the Impact of Meal Contents and Intake Timing on Drug Exposure.
Clin Pharmacol Drug Dev
; 13(4): 440-448, 2024 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38396317
10.
Safety, Tolerability, and Pharmacokinetics of Valemetostat Tablets and the Effect of Food on Valemetostat Pharmacokinetics in Healthy Subjects: Two Phase 1 Studies.
Clin Pharmacol Drug Dev
; 13(1): 77-86, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37565616
11.
EM, EM703 inhibit NF-kB activation induced by oxidative stress from diesel exhaust particle in human bronchial epithelial cells: importance in IL-8 transcription.
Pulm Pharmacol Ther
; 26(3): 318-24, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23291319
12.
Population pharmacokinetics of esaxerenone, a novel non-steroidal mineralocorticoid receptor blocker, in patients with essential hypertension, patients with diabetic nephropathy, and healthy volunteers.
Drug Metab Pharmacokinet
; 52: 100516, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37690271
13.
Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open-label, phase I study in healthy subjects.
Clin Transl Sci
; 16(11): 2153-2162, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37705321
14.
Agreement in regard to total sleep time during a nap obtained via a sleep polygraph and accelerometer: a comparison of different sensitivity thresholds of the accelerometer.
Int J Behav Med
; 19(3): 398-401, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21744139
15.
Acute effects of walking in forest environments on cardiovascular and metabolic parameters.
Eur J Appl Physiol
; 111(11): 2845-53, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21431424
16.
Effects of Repeated Oral Administration of Esaxerenone on the Pharmacokinetics of Midazolam in Healthy Japanese Males.
Eur J Drug Metab Pharmacokinet
; 46(5): 685-694, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34383278
17.
Quantitative analysis of an impact of P-glycoprotein on edoxaban's disposition using a human physiologically based pharmacokinetic (PBPK) model.
Int J Pharm
; 597: 120349, 2021 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33545293
18.
Randomized, Double-Blind, Single-Dose, Placebo-Controlled Crossover Study to Evaluate the Effects of Esaxerenone on QTc Interval in Healthy Subjects.
Clin Pharmacol Drug Dev
; 9(6): 709-718, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32255542
19.
Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects.
BMC Pharmacol Toxicol
; 21(1): 55, 2020 07 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32727577
20.
Pharmacokinetics and Safety of Single-Dose Esaxerenone in Japanese Subjects with Mild to Moderate Hepatic Impairment.
Adv Ther
; 37(1): 253-264, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31705436