Detalhe da pesquisa
1.
Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Substrate of Cytochrome P450 and Aldehyde Oxidase, Using Chimeric Mice With Humanized Liver.
Drug Metab Dispos
; 51(1): 67-80, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36273823
2.
CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate.
Drug Metab Dispos
; 50(3): 235-242, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34930785
3.
Evaluation of species differences in the metabolism of the selective NaV1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase.
Xenobiotica
; 51(9): 1060-1070, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34330191
4.
Pharmacokinetics of trastuzumab deruxtecan (T-DXd), a novel anti-HER2 antibody-drug conjugate, in HER2-positive tumour-bearing mice.
Xenobiotica
; 50(10): 1242-1250, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-32306807
5.
Comprehensive preclinical pharmacokinetic evaluations of trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody-drug conjugate, in cynomolgus monkeys.
Xenobiotica
; 49(9): 1086-1096, 2019 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-30351177
6.
In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions.
Xenobiotica
; 49(8): 961-969, 2019 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-30124356
7.
Identification of metals from osteoblastic ST-2 cell supernatants as novel OGR1 agonists.
J Recept Signal Transduct Res
; 35(5): 485-92, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26053506
8.
Species differences between rats and primates (humans and monkeys) in complex cleavage pathways of DS-8500a characterized by 14C-ADME studies in humans and monkeys after administration of two radiolabeled compounds and in vitro studies.
Drug Metab Pharmacokinet
; 45: 100459, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-35716472
9.
Cooperative binding interactions of glycopeptide antibiotics.
J Am Chem Soc
; 124(15): 3914-9, 2002 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-11942828
10.
Kinetic barriers and ordering of non-covalently bound states.
Org Biomol Chem
; 1(3): 472-7, 2003 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-12926247