Pesquisa | BVS Violência e Saúde

1.

The blood vasculature instructs lymphatic patterning in a SOX7-dependent manner.

Chiang, Ivy K N; Graus, Matthew S; Kirschnick, Nils; Davidson, Tara; Luu, Winnie; Harwood, Richard; Jiang, Keyi; Li, Bitong; Wong, Yew Yan; Moustaqil, Mehdi; Lesieur, Emmanuelle; Skoczylas, Renae; Kouskoff, Valerie; Kazenwadel, Jan; Arriola-Martinez, Luis; Sierecki, Emma; Gambin, Yann; Alitalo, Kari; Kiefer, Friedmann; Harvey, Natasha L; Francois, Mathias.

EMBO J ; 42(5): e109032, 2023 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-36715213

2.

A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity.

McCann, Alex J; Lou, Jieqiong; Moustaqil, Mehdi; Graus, Matthew S; Blum, Ailisa; Fontaine, Frank; Liu, Hui; Luu, Winnie; Rudolffi-Soto, Paulina; Koopman, Peter; Sierecki, Emma; Gambin, Yann; Meunier, Frédéric A; Liu, Zhe; Hinde, Elizabeth; Francois, Mathias.

Nucleic Acids Res ; 49(19): 10931-10955, 2021 11 08.

Artigo em Inglês | MEDLINE | ID: mdl-34570228

3.

α-Synuclein Strains and Their Relevance to Parkinson's Disease, Multiple System Atrophy, and Dementia with Lewy Bodies.

Graves, Noah J; Gambin, Yann; Sierecki, Emma.

Int J Mol Sci ; 24(15)2023 Jul 28.

Artigo em Inglês | MEDLINE | ID: mdl-37569510

4.

The Mediator complex and the role of protein-protein interactions in the gene regulation machinery.

Sierecki, Emma.

Semin Cell Dev Biol ; 99: 20-30, 2020 03.

Artigo em Inglês | MEDLINE | ID: mdl-30278226

5.

Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death.

Steain, Megan; Baker, Max O D G; Pham, Chi L L; Shanmugam, Nirukshan; Gambin, Yann; Sierecki, Emma; McSharry, Brian P; Avdic, Selmir; Slobedman, Barry; Sunde, Margaret; Abendroth, Allison.

PLoS Pathog ; 16(7): e1008473, 2020 07.

Artigo em Inglês | MEDLINE | ID: mdl-32649716

6.

Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.

Wang, Pingping; Zhou, Zhihong; Hu, Anchang; Ponte de Albuquerque, Claudio; Zhou, Yu; Hong, Lixin; Sierecki, Emma; Ajiro, Masahiko; Kruhlak, Michael; Harris, Curtis; Guan, Kun-Liang; Zheng, Zhi-Ming; Newton, Alexandra C; Sun, Peiqing; Zhou, Huilin; Fu, Xiang-Dong.

Mol Cell ; 54(3): 378-91, 2014 May 08.

Artigo em Inglês | MEDLINE | ID: mdl-24703948

7.

The RHIM of the Immune Adaptor Protein TRIF Forms Hybrid Amyloids with Other Necroptosis-Associated Proteins.

Baker, Max O D G; Shanmugam, Nirukshan; Pham, Chi L L; Ball, Sarah R; Sierecki, Emma; Gambin, Yann; Steain, Megan; Sunde, Margaret.

Molecules ; 27(11)2022 May 24.

Artigo em Inglês | MEDLINE | ID: mdl-35684320

8.

Rapid HIV-1 Capsid Interaction Screening Using Fluorescence Fluctuation Spectroscopy.

Lau, Derrick; Walsh, James C; Dickson, Claire F; Tuckwell, Andrew; Stear, Jeffrey H; Hunter, Dominic J B; Bhumkar, Akshay; Shah, Vaibhav; Turville, Stuart G; Sierecki, Emma; Gambin, Yann; Böcking, Till; Jacques, David A.

Anal Chem ; 93(8): 3786-3793, 2021 03 02.

Artigo em Inglês | MEDLINE | ID: mdl-33593049

9.

Ultrastructural localisation of protein interactions using conditionally stable nanobodies.

Ariotti, Nicholas; Rae, James; Giles, Nichole; Martel, Nick; Sierecki, Emma; Gambin, Yann; Hall, Thomas E; Parton, Robert G.

PLoS Biol ; 16(4): e2005473, 2018 04.

Artigo em Inglês | MEDLINE | ID: mdl-29621251

10.

Viral M45 and necroptosis-associated proteins form heteromeric amyloid assemblies.

Pham, Chi Ll; Shanmugam, Nirukshan; Strange, Merryn; O'Carroll, Ailis; Brown, James Wp; Sierecki, Emma; Gambin, Yann; Steain, Megan; Sunde, Margaret.

EMBO Rep ; 20(2)2019 02.

Artigo em Inglês | MEDLINE | ID: mdl-30498077

11.

Structure of a PSI-LHCI-cyt b₆f supercomplex in Chlamydomonas reinhardtii promoting cyclic electron flow under anaerobic conditions.

Steinbeck, Janina; Ross, Ian L; Rothnagel, Rosalba; Gäbelein, Philipp; Schulze, Stefan; Giles, Nichole; Ali, Rubbiya; Drysdale, Rohan; Sierecki, Emma; Gambin, Yann; Stahlberg, Henning; Takahashi, Yuichiro; Hippler, Michael; Hankamer, Ben.

Proc Natl Acad Sci U S A ; 115(41): 10517-10522, 2018 10 09.

Artigo em Inglês | MEDLINE | ID: mdl-30254175

12.

Single-Molecule Counting Coupled to Rapid Amplification Enables Detection of α-Synuclein Aggregates in Cerebrospinal Fluid of Parkinson's Disease Patients.

Bhumkar, Akshay; Magnan, Chloe; Lau, Derrick; Jun, Eugene Soh Wei; Dzamko, Nicolas; Gambin, Yann; Sierecki, Emma.

Angew Chem Int Ed Engl ; 60(21): 11874-11883, 2021 05 17.

Artigo em Inglês | MEDLINE | ID: mdl-33511725

13.

Homodimerization regulates an endothelial specific signature of the SOX18 transcription factor.

Moustaqil, Mehdi; Fontaine, Frank; Overman, Jeroen; McCann, Alex; Bailey, Timothy L; Rudolffi Soto, Paulina; Bhumkar, Akshay; Giles, Nichole; Hunter, Dominic J B; Gambin, Yann; Francois, Mathias; Sierecki, Emma.

Nucleic Acids Res ; 46(21): 11381-11395, 2018 11 30.

Artigo em Inglês | MEDLINE | ID: mdl-30335167

14.

Biophysical Techniques for Target Validation and Drug Discovery in Transcription-Targeted Therapy.

Moustaqil, Mehdi; Gambin, Yann; Sierecki, Emma.

Int J Mol Sci ; 21(7)2020 Mar 26.

Artigo em Inglês | MEDLINE | ID: mdl-32225120

15.

Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88.

O'Carroll, Ailís; Chauvin, Brieuc; Brown, James W P; Meagher, Ava; Coyle, Joanne; Schill, Jurgen; Bhumkhar, Akshay; Hunter, Dominic J B; Ve, Thomas; Kobe, Bostjan; Sierecki, Emma; Gambin, Yann.

BMC Biol ; 16(1): 149, 2018 12 24.

Artigo em Inglês | MEDLINE | ID: mdl-30583727

16.

Thinking Outside the Bug: Molecular Targets and Strategies to Overcome Antibiotic Resistance.

Monserrat-Martinez, Ana; Gambin, Yann; Sierecki, Emma.

Int J Mol Sci ; 20(6)2019 Mar 13.

Artigo em Inglês | MEDLINE | ID: mdl-30871132

17.

Design, Synthesis, and Evaluation of N- and C-Terminal Protein Bioconjugates as G Protein-Coupled Receptor Agonists.

Healey, Robert D; Wojciechowski, Jonathan P; Monserrat-Martinez, Ana; Tan, Susan L; Marquis, Christopher P; Sierecki, Emma; Gambin, Yann; Finch, Angela M; Thordarson, Pall.

Bioconjug Chem ; 29(2): 403-409, 2018 02 21.

Artigo em Inglês | MEDLINE | ID: mdl-29328675

18.

Unexpected instabilities explain batch-to-batch variability in cell-free protein expression systems.

Hunter, Dominic J B; Bhumkar, Akshay; Giles, Nichole; Sierecki, Emma; Gambin, Yann.

Biotechnol Bioeng ; 115(8): 1904-1914, 2018 08.

Artigo em Inglês | MEDLINE | ID: mdl-29603735

19.

Unveiling a Selective Mechanism for the Inhibition of α-Synuclein Aggregation by ß-Synuclein.

Leitao, Andre; Bhumkar, Akshay; Hunter, Dominic J B; Gambin, Yann; Sierecki, Emma.

Int J Mol Sci ; 19(2)2018 Jan 24.

Artigo em Inglês | MEDLINE | ID: mdl-29364143

20.

Editorial.

Sierecki, Emma; Gambin, Yann.

Semin Cell Dev Biol ; 99: 1-2, 2020 03.

Artigo em Inglês | MEDLINE | ID: mdl-31791692

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